Publications by authors named "Jian-fei Qiu"
Article Synopsis
- Eighteen cyclopenta[]benzopyran derivatives and ten limonoids were discovered, including ten new compounds, identified through advanced analytical techniques.
- Nine of these compounds showed strong cytotoxic effects on cancer cells, with IC values ranging from 3 to 900 nM.
- Sixteen compounds exhibited potent antiviral properties against the dengue virus, with selectivity index values between 13.0 and 532.6, and one compound may act as an eIF4E activator, potentially reducing dengue virus E protein expression.
Article Synopsis
- The study isolated three new sesquiterpenes (1-3) and six known analogues (4-9) from the plant Carpesium cernuum, determining their structures using advanced NMR and ECD techniques.
- The anti-leukemia effects of these compounds were tested on three different leukemia cell lines, revealing that compounds 1-3 displayed moderate cytotoxicity.
- Specifically, compound 2 showed promise as an anti-leukemia agent by inducing apoptosis through the downregulation of the Bcl-2 protein and activating caspase enzymes in K562 cells.
A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) method was developed to determine dihydrocodeine (DHC) in human plasma using diazepam as the internal standard (IS). Sample preparation was accomplished through a liquid-liquid extraction procedure with ethyl acetate. The analyte and IS were separated on an Acquity UPLC BEH C18 column (2.
View Article and Find Full Text PDFDetermination of kurarinone in rat plasma by UPLC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
April 2015
A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to determine kurarinone in rat plasma using chlorzoxazone as the internal standard (IS). Sample preparation was accomplished through a liquid-liquid extraction procedure with ethyl acetate to 0.2 mL plasma sample.
View Article and Find Full Text PDFUPLC-MS/MS method for determination of avicularin in rat plasma and its application to a pharmacokinetic study.
J Chromatogr B Analyt Technol Biomed Life Sci
August 2014
A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of avicularin in rat plasma. Sample preparation was accomplished through a simple one-step deproteinization procedure with 0.2 mL of acetonitrile-methanol (9:1, v/v) to a 0.
View Article and Find Full Text PDF[Chlorophyll content and net photosynthetic rate of Machilus pauhoi and M. leptophylla].
Ying Yong Sheng Tai Xue Bao
February 2009
By using SPAD-502 chlorophyll meter, LI-6400 portable photosynthesis system, and spectrophotometer, the leaf SPAD value, net photosynthetic rate (Pn), and chlorophyll (a + b) content (Ct) of 3-year-old Machilus pauhoi and M. leptophylla seedlings were measured, and the relationships of SPAD value with Pn and Ct were analyzed. The M.
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