Publications by authors named "Jian-Zhou Shi"
Article Synopsis
- Pyroptosis, a form of cell death, is linked to cardiovascular diseases, but the role of long noncoding RNAs (lncRNAs) in regulating this process in heart cells is not well understood.
- This study investigates the lncRNA FGF9-associated factor (FAF) and its effects on reducing cell death in acute myocardial infarction (AMI) by examining its interaction with miR-185-5p and PAK2 in heart cells exposed to low oxygen.
- Findings indicate that higher levels of lncRNA FAF can decrease pyroptosis in heart cells, improve cell survival, and lessen damage during AMI, suggesting that the FAF/miR-185-5p/PAK2
J Mol Cell Cardiol
May 2022
Article Synopsis
- Adult mammals struggle with heart regeneration after injury, while neonatal mice can fully recover their heart tissue within a week.
- Understanding factors that enhance the growth of heart cells (cardiomyocytes) is vital for creating effective cardiac regeneration treatments.
- This study found that the protein MNK2 significantly boosts cardiomyocyte proliferation, both in lab settings and in living mice, by activating a pathway involving eIF4E and cyclin D1, highlighting MNK2 as a promising target for heart repair therapies.
