Publications by authors named "Jian-Zhong Su"
Article Synopsis
- Researchers used single-cell RNA sequencing to analyze 18,596 cells from the human lens, uncovering two subtypes of lens epithelial cells that are distinguished by specific gene expressions (C8orf4 and ADAMTSL4).
- They discovered a new type of fiber cells near the epithelium and identified a potential subpopulation of lens epithelial stem/progenitor cells.
- The study also revealed two pathways for lens epithelial cell differentiation, highlighting significant gene changes occurring during this process.
Motivation: The mathematically optimal solution in computational protein folding simulations does not always correspond to the native structure, due to the imperfection of the energy force fields. There is therefore a need to search for more diverse suboptimal solutions in order to identify the states close to the native. We propose a novel multimodal optimization protocol to improve the conformation sampling efficiency and modeling accuracy of de novo protein structure folding simulations.
View Article and Find Full Text PDFendophthalmitis is a devastating eye infection that causes rapid blindness through extracellular tissue-destructive exotoxins. Despite its importance, knowledge of the phylogenetic relationships and population structure of intraocular spp. is lacking.
View Article and Find Full Text PDFObjective: To clarify whether functionally competent dendritic cells (DC) can be generated from malignant pleural effusion in patients with lung cancer.
Methods: Malignant effusion-associated monocytes were separated by adherence from malignant effusion-associated mononuclear cells and cultured in medium with granulocyte macrophage colony-stimulating factor (GM-CSF) plus interleukin 4 (IL-4). TNF-alpha was added for the last 24 h before culture termination.