Publications by authors named "Jian-Zhong Fan"

Article Synopsis
  • rTMS is an emerging treatment for traumatic brain injury (TBI) that enhances recovery by promoting neuroplastic changes in neurons and influencing supportive brain cells like microglia and astrocytes.
  • High-frequency rTMS was tested on rats with TBI, revealing that it helps preserve neuron structure and reduce cell death by altering inflammation-related proteins in microglia and astrocytes.
  • The study found that rTMS decreases harmful pro-inflammatory factors while increasing protective anti-inflammatory ones, suggesting it plays a crucial role in reducing neurological damage after TBI.
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Organic multilayer heterostructures with accurate spatial organization demonstrate strong light-matter interaction from excitonic responses and efficient carrier transfer across heterojunction interfaces, which are considered as promising candidates toward advanced optoelectronics. However, the precise regulation of the heterojunction surface area for finely adjusting exciton conversion and energy transfer is still formidable. Herein, organic bilayer heterostructures (OBHs) with controlled face-to-face heterojunction via a stepwise seeded growth strategy, which is favorable for efficient exciton propagation and conversion of optical interconnects are designed and synthesized.

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Highly spatial and angular precision in epitaxial-growth process is crucial for constructing organic low-dimensional heterostructures (OLDHs) with the desired substructures, which remains significant challenge owing to the unpredicted location of complex heterogeneous nucleation. Herein, a dynamic epitaxial-growth approach is developed along the tailored longitudinal/horizontal directions to create diverse OLDHs with hierarchical architectures. The controlled morphology evolution of seed crystals from kinetic to thermodynamic species is achieved via incrementally increasing the crystallization time from 0 to 600 s.

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Studies have shown that repetitive transcranial magnetic stimulation (rTMS) can enhance synaptic plasticity and improve neurological dysfunction. However, the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood. In this study, we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.

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Background: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a promising therapeutic intervention for neurological disorders. However, the precise mechanisms of rTMS in neural excitability remains poorly understood. Estradiol is known to have strong influence on cortical excitability.

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Two donor-acceptor motif fulvene-containing boron complexes were synthesized with fulvene diketonate boron difluoride (FDB) as the organic acceptor. Both difluoroboron complexes present aggregation-induced emission (AIE) properties and cell tracing function with excellent biocompatibility. And mechanochromic luminescence has been accomplished by the synthesis, isolation and characterization of BL2.

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A series of supramolecular assemblies of types [Ag (L) ](PF ) and [Ag (L) ](PF ) , obtained from the tetraphenylethylene (TPE) bridged tetrakis(1,2,4-triazolium) salts H -L(PF ) and Ag ions, is described. The assembly type obtained dependends on the N-wingtip substituents of H -L(PF ) . Changes in the lengths of the N4-wingtip substituents enables controlled formation of assemblies with either [Ag (L) ](PF ) or [Ag (L) ](PF ) stoichiometry.

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Circularly polarized luminescence molecules with both thermally activated delayed fluorescence (TADF) and aggregation-induced emission (AIE) have been reported recently and are thought as potential candidates for circular polarized organic light-emitting diodes. Since the study of these kinds of systems is quite limited, it is of great importance to reveal the relationship between the geometry and the light-emitting mechanism. In this paper, the TADF and AIE mechanisms were studied based on the study of a series of binaphthalene-containing luminogenic enantiomers in both toluene and solid phases.

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Objectives: Hypermucoviscous Klebsiella pneumoniae (HMKP) has been increasingly observed among clinical isolates. This study sought to examine the microbiological and epidemiological characteristics of HMKP strains in a tertiary hospital in Hangzhou, China.

Methods: HMKP isolates were collected and were identified via matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS).

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Carbapenem-resistant Acinetobacter baumannii (CRAB) is a common nosocomial bacterial pathogen with limited treatment options. CRAB outbreaks are disastrous for critically ill patients. This study investigated carbapenemase-produced A.

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Objective: To evaluate trunk muscle strength and EMG activation during isokinetic axial rotation at different angular velocities.

Method: Twenty-four healthy young men performed isokinetic axial rotation in right and left directions at 30, 60, and 120 degrees per second angular velocity. Simultaneously, surface EMG was recorded on external oblique (EO), internal oblique (IO), and latissimus dorsi (LD) bilaterally.

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Based on the sub-pixel analysis model, and by using 2000-2009 MODIS NDVI (250 m resolution), this paper quantitatively analyzed the spatiotemporal change characteristics and their causes of fractional vegetation coverage (FVC) in Shannxi Province. From 2000 to 2009, the FVC in the Province had a significant increasing trend, with the great magnitude of 35.0%.

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Objective: To study the effects of pulsed magnetic field on insulin-like growth factor-1 (IGF-1) level in the cerebrospinal fluid (CSF) and the association of IGF-1 alterations with the activities of daily living (ADL) of patients with brain injury.

Methods: Sixty-five patients with brain injury were divided randomly into the control group (n=30) and magnetic therapy group (n=35), both receiving conventional therapy and in the latter group, daily pulsed magnetic field treatment (20-40 mT, 50 Hz, 20 min per time, 1 time per day) for 14 consecutive days were administered. On the first and 14th days of the treatment, 2 ml CSF was collected from the cases patients for IGF-1 measurement by radioimmunoassay, and Barthel index (BI) was used to assess the ADL of the patients.

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Objective: To investigate the effect of infrasound therapy on the proliferation, apoptosis and ultrastructure of human B lymphoma Raji cells.

Methods: Human B lymphoma Raji cells were exposed to infrasound treatment for 15, 30, 60, 90 and 120 min and cultured subsequently for 24 or 48 h. MTT assay, flow cytometry analysis, and electron microscopy were performed to examine the proliferative status, cell apoptosis and ultrastructural changes of the exposed cells, respectively.

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Objective: To evaluate the effect of infrared radiation and magnetic field therapy on cartilage damage in rabbits with knee osteoarthritis.

Methods: Knee osteoarthritis was induced in 24 adult New Zealand rabbits by prolonged fixation of the knee joint in extension for 6 weeks. The rabbits were subsequently randomized into control group (without treatment), infrared therapy group, magnetic field therapy group and the combined infrared and magnetic field therapy group.

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Objective: To investigate nestin activation in rat brain subjected to ischemia-reperfusion injury and its changes in response to Tongxinluo treatment.

Methods: Cerebral ischemia was induced by temporary middle cerebral artery occlusion (MCAO) in rats. At 3, 7, 14 and 21 days after MCAO, nestin expression in the ependyma, subventricular zone (SVZ), hippocampal subdentate gyrus zone (HDG) of the rats treated with Tongxinluo were guantified by immunohistochemistry.

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Objective: To explore mechanisms of acupuncture in treatment of vertebrobasilar insufficiency.

Methods: Forty cases of vertebrobasilar insufficiency (VBI) were divided into an acupuncture group and a routine treatment group, 20 cases in each group. The acupuncture group were treated by routine treatment plus acupuncture.

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