The survival and outcome of older patients with primary aneurysmal subarachnoid haemorrhage: a 2-year follow-up, multi-centre, observational study.

Background And Purpose: The management of older aneurysmal subarachnoid haemorrhage (aSAH) cases is a clinical challenge. This study aimed to analyse the survival and functional outcomes in older aSAH patients (age ≥ 70 years) to provide evidence for making treatment decisions for such patients.

Methods: We performed a 2-year follow-up analysis of the Chinese Multi-Centre Cerebral Aneurysm Database for older patients suffering from aSAH from 2017 to 2020.

Bifunctional Lanthanide-Based Coordination Polymers: Conversion of CO and Highly Selective Luminescence Sensing for Acetylacetone.

A series of bifunctional Ln(III)-based coordination polymers (CPs) {Ln(L)(DMA)(NO)} [Ln(III) = Eu (), Gd (), and Dy (); organic ligand HL = 2,2'-(1,3,5,7-tetrahydroxyoctahydro-4,8-ethanopyrrolo[3,4-]isoindole-2,6(1,3)-diyl)diacetic acid)] have been successfully synthesized. CPs - are isostructural and constructed from the dimeric Ln unit in which two adjacent Ln ions are bridged by two μ-carboxyl oxygens, and the Ln dimeric unit is connected by two NO ions, four DMA molecules, and four completely protonated L ligands forming a 2D layer structure. The magnetic research reveals that CP shows a significant cryogenic magnetocaloric effect (-Δ = 22.

Two novel Ln clusters bridged by CO effectively convert CO into oxazolidinones and cyclic carbonates.

It is difficult and challenging to design and construct high-nuclearity Ln(III)-based clusters due to the high coordination numbers and versatile coordination geometries of Ln(III) ions. Herein, two novel octanuclear Ln(III)-based clusters [Ln(HL)(HL)(NO) (CO)](NO)·2CHCN (Ln = Nd (1) and Sm (2)) have been synthesized under solvothermal conditions. The X-ray single analysis reveals that both 1 and 2 are octanuclear structures and the eight central Ln(III) ions are bridged by two CO anions.

Fabrication of Magnetic Al-Based FeO@MIL-53 Metal Organic Framework for Capture of Multi-Pollutants Residue in Milk Followed by HPLC-UV.

The efficient capture of multi-pollutant residues in food is vital for food safety monitoring. In this study, in-situ-fabricated magnetic MIL-53(Al) metal organic frameworks (MOFs), with good magnetic responsiveness, were synthesized and applied for the magnetic solid-phase extraction (MSPE) of chloramphenicol, bisphenol A, estradiol, and diethylstilbestrol. Terephthalic acid (HBDC) organic ligands were pre-coupled on the surface of amino-FeO composites (HBDC@FeO).

Molecular assemblies from linear-shaped Ln clusters to Ln clusters using different β-diketonates: disparate magnetocaloric effects and single-molecule magnet behaviours.

A series of tetranuclear lanthanide-based clusters [Ln(dbm)(L)(CHOH)]·2CHOH (Ln(III) = Gd (1), Dy (2), and Ho (3); HL = 2-[(2-(hydroxyimino)propanehydrazide)methyl]-2,3-dihydroxybenzaldehyde, Hdbm = dibenzoylmethane) and octanuclear lanthanide-based clusters [Ln(HL)(CHO)(CHOH)]·6CHOH (Ln(III) = Gd (4), Dy (5)) were assembled using a polydentate Schiff-base ligand HL and two different β-diketone salts a solvothermal method, and their structures and magnetic properties have been characterized. Interestingly, β-diketones play an important role in assembling and affecting the structures of Ln to Ln clusters. This is the first use of β-diketone to affect the structures of polynuclear Ln(III)-based clusters from linear-shaped Ln clusters to Ln clusters.

Piceatannol protects against cerebral ischemia/reperfusion‑induced apoptosis and oxidative stress via the Sirt1/FoxO1 signaling pathway.

Reperfusion is a critical therapeutic intervention used following acute ischemic stroke; however, it may cause cerebral ischemia/reperfusion injury (CIRI) and aggravate brain damage. Piceatannol (Pic), a hydroxylated analog of resveratrol, has been reported to exhibit anti‑inflammatory effects. However, the detailed molecular mechanisms and its effects on CIRI have not been sufficiently assessed, and, to the best of our knowledge, current methods of prevention of CIRI are limited.

Solvent-Dependent Assembly and Magnetic Relaxation Behaviors of [CuI] Cluster-Based Lanthanide MOFs: Acting as Efficient Catalysts for Carbon Dioxide Conversion with Propargylic Alcohols.

Two structurally similar metal-organic frameworks (MOFs) [DyCuI(IN)(DMF)]·DMF () and [DyCuI(IN)(DMA)]·DMA () (HIN = isonicotinic acid) feathering different coordinated solvent molecules were successfully isolated by tuning the types of solvents in the reaction system. Structural tests indicate that and are both built from 1D Dy(III) chains and copper iodide clusters [CuI], generating into three-dimensional frameworks with an open 1D channel along the axis. and display extensive and excellent solvent stability.

Long-term chemogenetic activation of M1 glutamatergic neurons attenuates the behavioral and cognitive deficits caused by intracerebral hemorrhage.

Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening disease. It is often accompanied by severe neurological sequelae largely caused by the loss of integrity of the neural circuits. However, these neurological sequelae have few strong medical interventions.

Modulation of the properties of dinuclear lanthanide complexes through utilizing different β-diketonate co-ligands: near-infrared luminescence and magnetization dynamics.

A family of new dinuclear lanthanide complexes as the simplest entities showing intramolecular magnetic interactions, [Ln2(dbm)2(L)2(CH3OH)2] (Ln = Tb (1), Dy (2), Ho (3), Er (4), Yb (5), Lu (6)), [Ln2(acac)2(L)2(EtOH)2] (Ln = Dy (7), Er (8)), [Dy2(TTA)2(L)2(CH3OH)2]·2CH2Cl2 (9) and [Dy2(tfa)2(L)2(CH3OH)2] (10) (H2L = N'-(2-hydroxy-5-methylphenyl)-pyrazine-2-carbohydrazide, Hdbm = 1,3-diphenyl-1,3-propanedione, Hacac = acetylacetone, HTTA = 2-thenoyltrifluoroacetone, Htfa = trifluoroacetylacetone), were constructed successfully by the reaction of a Schiff base ligand H2L and four different β-diketonate salts. As for complexes 4, 5 and 8, all exhibit the characteristic emission peaks of the corresponding Er3+, Yb3+ and Er3+ ions, respectively. Meanwhile, the excitation wavelength (510 nm) of 5 is located in the visible region, confirming its significant potential application value.

Linear-shaped Ln and Ln clusters constructed by a polydentate Schiff base ligand and a β-diketone co-ligand: structures, fluorescence properties, magnetic refrigeration and single-molecule magnet behavior.

Herein, ten new linear-shaped LnIII4 and LnIII6 clusters, with the formula [Ln4(acac)6L2(CH3O)2(CH3OH)4]·xCH3OH (Ln = Nd (1), Sm (2), Eu (3), Gd (4), Tb (5), Dy (6), and Tm (8), Hacac = acetylacetone), [Ln6(acac)4L4(CH3O)6]·xCH3OH (Er (7) and Yb (9)), and [Lu4(acac)6L2(OH)2]·2CH2Cl2 (10), based on a polydentate Schiff base ligand, H2L, and a β-diketone co-ligand were successfully synthesized and structurally characterized. Single crystal X-ray diffraction measurements reveal that the structures of the clusters 1-6, 8 and 10 are very similar and their central Ln(iii) ions are linearly arranged Ln4; however, the clusters 7 and 9 possess a rare linearly arranged Ln6. The investigations on the solid-state fluorescence properties show that the clusters 2, 3, 5 and 6 display the characteristic lanthanum luminescence at room temperature.

Dynamically NAND gate system on DNA origami template.

Molecular logic gates play an important role in many fields and DNA-based logic gates are the basis of DNA computers. A dynamically NAND gate system on the DNA origami template is established in this paper. Naturally, the system is stable in solution without any reaction.

Water Stable [Tb] Cluster-Based Metal-Organic Framework as Sensitive and Recyclable Luminescence Sensor of Quercetin.

A novel 3D metal-organic framework (MOF){[Tb(CBA)(HCOO)(μ-OH)(HO)]·2HO·0.5DMF} (S-1) was synthesized by the solvothermal method. The crystal structure indicates that [TbO] cubane clusters self-assemble into an infinite chain by sharing vertex, which is further linked to adjacent chains through 1,1-cyclobutanedicarboxylic acid ligand (HCBA), resulting in a honeycomb arrayed framework.

A new family of dinuclear lanthanide complexes constructed from an 8-hydroxyquinoline Schiff base and β-diketone: magnetic properties and near-infrared luminescence.

Six phenoxo-O bridged dinuclear lanthanide(iii) complexes have been assembled utilizing the 2-[(4-nitrophenyl)imino]methyl-8-hydroxyquinoline (HL) and dibenzoylmethane (Hdbm) ligands: [Ln2(dbm)4L2] (Ln = Nd (1), Eu (2), Gd (3), Tb (4), Dy (5) and Er (6)). Complexes 1 and 6 exhibit the characteristic emission peaks of the corresponding Nd3+ and Er3+ ions, respectively. Meanwhile, the excitation wavelength (470 nm) for complex 1 is located in the visible-light region, confirming a practical application value.

Two luminescent lanthanide(iii) metal-organic frameworks as chemosensors for high-efficiency recognition of Cr(vi) anions in aqueous solution.

Two new lanthanide(iii) metal-organic frameworks (MOFs) {[(CH3)2NH2]2[Ln4(FDA)7(DMF)2]·0.5DMF}n [Ln = Eu (1), and Tb (2)] based on furan-2,5-dicarboxylic acid (H2FDA) have been successfully assembled and well characterized in detail. These MOFs are isostructural and demonstrate 12-connected sqc15 topologies, which are rarely observed in MOF chemistry, especially in lanthanide(iii) MOFs.

Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression.

The aim of the present study was to investigate the protective effect of dexmedetomidine (Dex) on traumatic brain injury (TBI), and further evaluate whether the underlying neuroprotective mechanisms are associated with neurological apoptosis and the expression of 70 kDa heat shock protein (HSP70) in the hippocampus. A total of 90 adult male Sprague‑Dawley rats were randomly assigned into 3 groups (n=30/group): Sham, TBI and Dex groups. The rat models of TBI were established using a modified weight‑drop device and Dex (15 µg/kg) was intravenously administered immediately following TBI.

Wheel-like Ln Cluster Organic Frameworks for Magnetic Refrigeration and Conversion of CO.

Two isostructural 2D MOFs ([Ln(CDA)(HCOO)(μ-OH)(HO)] , abbreviated as 1-Gd and 2-Dy) were successfully synthesized under solvothermal conditions. The self-assembly of lanthanide(III) nitrate and 1,1'-cyclopropane-dicarboxylic acid (HCDA) resulted in wheel-like Ln cluster second building units (SBU), which are further linked to six neighboring wheels to generate a 2D ordered honeycomb array. Both 1-Gd and 2-Dy exhibit high thermal stability and decompose above 330 °C.

Magnetic properties and structure of tetranuclear lanthanide complexes based on 8-hydroxylquinoline Schiff base derivative and β-diketone coligand.

Five tetranuclear lanthanide complexes [Gd(dbm)(L)(μ-OH)]·5CHCN (1), [Tb(dbm)(L)(μ-OH)]·2CHCHOH·4CHCN (2), [Dy(dbm)(L)(μ-OH)]·4CHCN·2HO (3), [Ho(dbm)(L)(μ-OH)]·CHCHOH·4CHCN·2HO (4) and [Er(dbm)(L)(μ-OH)] (5) are obtained from the reaction of 5-(4-pyridinecarboxaldehyde)amino-8-hydroxylquinoline (HL) and Ln(dbm)·2HO (dbm = 1,3-diphenyl-1,3-propanedione). Complexes 1-5 are isomorphous and crystallize in the monoclinic space group P2/c. The metal ions in 1-5 adopt an approximately square-antiprismatic coordination environment.

Enhancement of Polarization in Ferroelectric Films via the Incorporation of Gold Nanoparticles.

Ferroelectric thin films have been extremely studied for many applications such as nonvolatile memories, super capacitors, and solar cells. For these devices, improving the polarization properties of ferroelectric thin films is of great significance to their performance. Here, Au-lead zirconate titanate (PZT) nanocomposite thin films were prepared by a simple one-step chemical solution deposition (CSD) method on silicon substrates, and the effects of Au concentration on the ferroelectric properties were investigated.

Therapeutic effects of conditioned medium from bone marrow-derived mesenchymal stem cells on epithelial-mesenchymal transition in A549 cells.

Pulmonary fibrosis (PF) is a chronic lung disease. The transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis. Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to be a modulator of the molecular aspects of the fibrosis pathway.

Tuning the luminescence of two 3d-4f metal-organic frameworks for the fast response and highly selective detection of aniline.

Two 3D solvent-stable zinc(ii)-lanthanide(iii) heterometallic metal-organic frameworks (MOFs) {[(CH)NH][ZnLn(FDA)(DMF)]·2DMF} [Ln = Eu (Zn-Eu) and Tb (Zn-Tb); HFDA = furan-2,5-dicarboxylic acid] based on ZnLn(COO) tetrametallic clusters and furan-2,5-dicarboxylic acid have been successfully synthesized. These MOFs can serve as luminescent sensors for the fast response and highly selective detection of aniline via luminescence quenching. More importantly, a linear correlation is observed between their luminescence and the low concentration of aniline and the detection limits of aniline are 7.

A unique zinc-organic framework constructed through in situ ligand synthesis for conversion of CO under mild conditions and as a luminescence sensor for CrO/CrO.

A novel zinc-organic framework, {[Zn(tza)(μ-OH)(HO)]·HO} (1) (Htza = 1H-tetrazolate-5-acetic acid), was synthesized through an in situ generated tetrazole ligand under hydrothermal conditions. In compound 1, tza ligands and Zn are interlinked to form 2D layers, which are further pillared through μ-OH groups to generate a 3D framework. Thermogravimetric analysis and powder X-ray diffraction confirm that 1 has high thermal stability, pH stability and solvent stability.

A Dy4 single-molecule magnet and its Gd(iii), Tb(iii), Ho(iii), and Er(iii) analogues encapsulated by an 8-hydroxyquinoline Schiff base derivative and β-diketonate coligand.

Five new tetranuclear complexes based on an 8-hydroxyquinoline Schiff base derivative and the β-diketone coligand, [Ln(acac)L(μ-OH)]·CHCN·0.5CHCl (Ln = Gd (1), Tb (2), Dy (3), Ho (4) and Er (5); HL = 5-(benzylidene)amino-8-hydroxyquinoline; acac = acetylacetonate) have been synthesized, and structurally and magnetically characterized. Complexes 1-5 have similar tetranuclear structures.

Resistive Switching and Modulation of Pb(ZrTi)O/Nb:SrTiO Heterostructures.

In this work, epitaxial Pb(ZrTi)O (PZT) thin films with different thicknesses were deposited on Nb-doped SrTiO (NSTO) single-crystal substrates by chemical solution deposition (CSD), and their ferroelectric resistive switching behaviors were investigated. The results showed that the maximum ON/OFF ratio up to 850 could be obtained in the PZT/NSTO heterostructure with the 150 nm thick PZT film. On the basis of the Schottky-Simmons model and the modified semiconductor theory, we also evaluated the interfacial built-in field and the depletion layer at the PZT/NSTO interface, which can be modulated strongly by the ferroelectric polarization, but are independent of the thickness of the PZT thin films.

Modulation of the relaxation dynamics of linear-shaped tetranuclear rare-earth clusters through utilizing different solvents.

Nine new tetranuclear centrosymmetric linear complexes, [RE(dbm)L(DMF)]·nCHCl·mCHN (RE = Y (1), Tb (2), Dy (3), Ho (4), Er (5), Lu (6)) and [RE(dbm)L(CHOH)]·nCHCN (RE = Tb (7), Dy (8), Ho (9)) (HL = 2-[(2-(hydroxyimino)propanehydrazide)methyl]-8-hydroxyquinoline and dbm = 1,3-diphenyl-1,3-propanedione) have been synthesized. Complexes 1-9 are tetranuclear complexes. Magnetic studies reveal that both Dy-based complexes (3 and 8) exhibit single-molecule magnet (SMM) behavior under a zero dc field.

Single-Molecule-Magnet Behavior and Fluorescence Properties of 8-Hydroxyquinolinate Derivative-Based Rare-Earth Complexes.

Five tetranuclear rare-earth complexes, [RE4(dbm)4L6(μ3-OH)2] [HL = 5- (4-fluorobenzylidene)-8-hydroxylquinoline; dbm = 1,3-diphenyl-1,3-propanedione; RE = Y (1), Eu (2), Tb (3), Dy (4), Lu (5)], have been synthesized and completely characterized. The X-ray structural analyses show that each [RE4] complex is of typical butterfly or rhombus topology. Each RE(III) center exists in an eight-coordinated square-antiprism environment.