EHMT2 promotes the pathogenesis of hepatocellular carcinoma by epigenetically silencing APC expression.

Background: Hepatocellular carcinoma (HCC), the second leading cause of cancer death worldwide, alone accounts for over half (466,100) of new cancer cases and 422,100 deaths based on the average year incidence rates of 2009 to 2011 in China. Due to unclear and complex underlying mechanisms for HCC development, effective therapy for HCC is still unavailable. The Wnt-β-catenin pathway is a critical contributor of HCC pathogenesis: 40-70% of HCCs from patients harbor the nuclear accumulation of β-catenin protein.

[Removal of Organic Matter from Water by Chemical Preoxidation Coupled with Biogenic Manganese Oxidation].

In the process of drinking water treatment, potassium permanganate and iron-manganese oxides are typical pre-oxidation methods that can not only effectively remove organic matters in drinking water, but also reduce the production of disinfection by-products (DBPs). However these two pre-oxidation methods will produce Mn that is genotoxic. In order to solve this problem, a concept was proposed to connect biogenic-manganese oxidation technology after chemical oxidation.