Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.

Background & Aims: Sleep disorders (SDs) are common in chronic liver diseases (CLDs). Some SDs arise from impaired internal clock and are, hence, circadian rhythm SDs (CRSDs). Bile acids (BAs), whose levels are increased in many CLDs, reciprocally interact with circadian rhythm.

PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene.

Background: Aerobic glycolysis is a tumor cell phenotype and a hallmark in cancer research. The alternative splicing of the pyruvate kinase M (PKM) gene regulates the expressions of PKM1/2 isoforms and the aerobic glycolysis of tumors. Polypyrimidine tract binding protein (PTBP1) is critical in this process; however, its impact and underlying mechanisms in colorectal cancer (CRC) remain unclear.

The origins of COVID-19 pandemic: A brief overview.

The novel coronavirus disease (COVID-19) outbreak that emerged at the end of 2019 has now swept the world for more than 2 years, causing immeasurable damage to the lives and economies of the world. It has drawn so much attention to discovering how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated and entered the human body. The current argument revolves around two contradictory theories: a scenario of laboratory spillover events and human contact with zoonotic diseases.

Upregulation of α enolase (ENO1) crotonylation in colorectal cancer and its promoting effect on cancer cell metastasis.

Lysine crotonylation (Kcr) is a newly identified protein translational modification and is involved in major biological processes including glycolysis, but its role in colorectal cancer (CRC) is unknown. Here, we found that the Kcr of α enolase (ENO1) was significantly elevated in human CRC tissues compared with the paratumoral tissues. CREB-binding protein (CBP) functioned as a crotonyltranferase of ENO1, and SIRT2 was involved in the decrotonylation of ENO1.

Discovering novel hub genes and pathways associated with the pathogenesis of psoriasis.

In-depth analysis on the rambling genes of psoriasis may help to identify the pathologic mechanism of this disease. However, this has seldom been performed. Using bioinformatic approaches, we analyzed four gene expression profiles in gene expression omnibus (GEO) database, identified the differentially expressed genes (DEGs), and found out the overlapping DEGs (common DEGs, CDEGs) in the above four profiles.

A Zn(ii) metal-organic framework based on bimetallic paddle wheels as a luminescence indicator for carcinogenic organic pollutants: phthalate esters.

Based on the multifunctional ligand 3-(1-1,2,4-triazol-1-yl)isophthalic acid (HTIA), a three-dimensional coordination polymer, namely {[Zn(TIA)]·DMA} (Zn-1) was synthesized solvothermally. Single-crystal X-ray diffraction analyses confirmed that Zn-1 is a 3D framework composed of binuclear Zn paddle wheels with one-dimensional channels long the direction. Further topological analyses revealed that MOF Zn-1 existed as a (3,6)-connected binodal net {4·6}{4·6·8}.

Terbium Triangle Bridged by a Triazole Nitronyl Nitroxide Radical with Single-Molecule-Magnet Behavior.

An unprecedented cyclic Tb-radical cluster, [Tb(hfac)(4-Me-3-NITtrz)(OH)] (), has been self-assembled from Tb(hfac)·2HO and 4-Me-3-NITtrz in the presence of Cu(hfac)·2HO. Alternating-current magnetic studies show that the Tb cluster displays a dual slow relaxation of magnetization behavior under a zero direct-current (dc) field and a single relaxation process under an induced dc field with an effective energy barrier of 14 K, representing the first triangle 2p-4f cluster with a slow magnetic relaxation property.

Synthesis of a series of hetero-multi-spin LnCu complexes based on a methyl-pyrazole nitronyl nitroxide radical with slow magnetic relaxation behaviors.

Multinuclear hetero-tri-spin complexes based on a methyl-pyrazole nitronyl nitroxide radical, namely, [Ln2Cu3(hfac)12(4-NIT-MePyz)4] (Ln = Gd(1), Tb(2), Dy(3); hfac = hexafluoroacetylacetone; 4-NIT-MePyz = 2-{4-(1-methyl)-pyrazolyl}-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) have been successfully obtained through a one-pot reaction of the radical ligand (4-NIT-MePyz) with Cu(hfac)2 and Ln(hfac)3. These 2p-3d-4f complexes exhibit five-nuclear structures with the sequence [Cu-Rad-Ln-Rad-Cu-Rad-Ln-Rad-Cu], in which each 4-NIT-MePyz radical acting as a bidentate bridging ligand is coordinated to one Ln(hfac)3 unit through one oxygen atom of the NO groups and to one Cu(hfac)2 unit with one nitrogen atom from the pyrazole ring. For complex 1, based on the spin Hamiltonian calculations and MAGPACK program, it is concluded that there exist ferromagnetic couplings between GdIII and NIT radicals, as well as between CuII and free radicals with J1 = 6.

Two 3D Cobalt(II) Metal-Organic Frameworks with Micropores for Selective Dye Adsorption.

Two porous coordination polymers, {[Co(TBC)]·2DMF} (1) and {[Co(TBC)Cl(CHOH)]·0.5Cl} (2), were synthesized via the solvothermal reaction of cobalt(II) salts and 3,5-bis(1 H-1,2,4-triazol-1-yl)benzenecarboxylic acid. Single-crystal X-ray diffraction analyses exhibited that complex 1 contains rtl three-dimensional (3D) skeleton and one-dimensional channels with large apertures, while complex 2 displays a novel 2-nodal 3,6-linked 3D structure with a Schläfli sign of {4.