Publications by authors named "Jian-Yuan Kang"
Article Synopsis
- Gastric intestinal metaplasia (IM) is identified as a precancerous condition linked to a higher risk of stomach cancer, and Weiwei Decoction (WWD) is a traditional Chinese herbal remedy aimed at treating IM.
- The study aimed to investigate how WWD affects the OLFM4/NOD1/CDX2 signaling pathway in IM, utilizing various laboratory methods including immunohistochemistry and cell models.
- Results showed that the OLFM4/NOD1/CDX2 pathway is crucial for IM progression, with WWD enhancing gastric tissue health by reducing OLFM4 and increasing NOD1 expression, ultimately leading to decreased CDX2 levels.
(), a group 1 human gastric carcinogen, is significantly associated with chronic gastritis, gastric mucosal atrophy, and gastric cancer. Approximately 20% of patients infected with develop precancerous lesions, among which metaplasia is the most critical. Except for intestinal metaplasia (IM), which is characterized by goblet cells appearing in the stomach glands, one type of mucous cell metaplasia, spasmolytic polypeptide-expressing metaplasia (SPEM), has attracted much attention.
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