The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway.

CCN1, a secreted matrix-associated molecule, is involved in multiple cellular processes. Previous studies have indicated that expression of CCN1 correlates inversely with the aggressiveness of non-small-cell lung carcinoma (NSCLC); however, the underlying mechanisms remain elusive. Using three NSCLC cell line systems, here we show that long-term treatment of cells with the recombinant CCN1 protein led to a permanent cell cycle arrest in G1 phase; cells remained viable as judged by apoptotic assays.

[The ratio of soft and hard after bimaxillary operations in patients with skeletal class III malformations].

Objective: To study the ratio between soft and hard tissue on the horizontal plane after the operations of maxillary Le Fort I advancement osteotomy and mandibular setback osteotomy in patient with skeletal class III malformations. It can help to predict precisely the post-operational profile.

Methods: 20 patients with skeletal class III malformation were taken cephalometric films pre-and post-operationally.