Publications by authors named "Jian-Xu Rao"
Article Synopsis
- The study investigates the relationship between HNF1α, endoplasmic reticulum (ER) stress, and hepatocyte apoptosis in severe acute exacerbation of liver injury.
- Experiments on liver cells and CCl-injured mice reveal that ER stress induces significant apoptosis and increases HNF1α levels, which are regulated by NF-κB activation.
- Low-dose lipopolysaccharide (LPS) worsens liver injury by disrupting the feedback loop between HNF1α and ER stress, leading to further hepatocyte apoptosis.
Alpha-fetoprotein (AFP) and endoplasmic reticulum (ER) stress play multiple roles in hepatocellular carcinoma. Here, we analyzed the crosstalk between AFP and ER stress in human hepatoma cells. We induced ER stress in human hepatoma cell lines (HepG2 and SK-Hep1 cells) with thapsigargin (TG, an ER stress inducer), and mitigated ER stress with 4-phenylbutyrate acid (4-PBA, an ER stress inhibitor).
View Article and Find Full Text PDF