Publications by authors named "Jian-Xiao Liang"
Article Synopsis
- * bsProbe shows significantly improved tumor accumulation—about six times more than traditional probes—enhancing detection capabilities for small tumors and providing a clearer distinction between malignant and benign tissues.
- * With a specificity of 90.48% and sensitivity of 92.22% based on analysis of 195 bladder cancer specimens, the bsProbe could improve early diagnosis and may aid in imaging-guided surgeries for tumors that are not visible.
Biomacromolecules, such as proteins, nucleic acids and polysaccharides, are widely distributed in the human body, and some of them have been recognized as the targets of drugs for disease theranostics. Drugs typically act on targets in two ways: non-covalent bond and covalent bond. Non-covalent bond-based drugs have some disadvantages, such as structural instability and environmental sensitivity.
View Article and Find Full Text PDFNano Proteolysis Targeting Chimeras (PROTACs) with Anti-Hook Effect for Tumor Therapy.
Angew Chem Int Ed Engl
September 2023
Article Synopsis
- PROTACs are a new drug development approach that targets and degrades specific proteins, but face challenges like off-target effects and the "hook effect."
- Researchers have introduced Nano-PROTACs, which can self-assemble inside tumor cells and effectively degrade proteins in a controlled manner, avoiding the hook effect.
- These Nano-PROTACs have shown a high degradation rate (95%) for proteins like EGFR and AR in lab tests, and have successfully inhibited tumor growth in mice models, suggesting potential for clinical applications.
Article Synopsis
- Anti-PD-L1 monoclonal antibodies have shown success in empowering T-cells for tumor immunotherapy, but challenges remain due to low T-cell infiltration and high levels of extracellular matrix hindering effectiveness.
- A new peptide-based bispecific nanoblocker (BNB) strategy is designed to target CXCR4 and PD-L1, helping increase T-cell infiltration and activation by forming nanoclusters directly on tumor cells.
- The BNB demonstrates a significantly longer half-life in tumors compared to plasma, leading to better tumor accumulation and fewer side effects, ultimately improving immunotherapy outcomes by reducing tumor stress from matrix components.
Aggregation-induced emission luminogens (AIEgens) possess enhanced fluorescence in highly aggregated states, thus enabling AIEgens as a promising module for highly emissive fluorescence biomaterials. So far, AIEgens-based nanomaterials and their hybrids have been reported for biomedical applications. Benefiting from the intrinsic biocompatibility and biofunction-editing properties of peptides, peptide-AIEgens hybrid biomaterials reveal unlimited possibilities including target capacity, specificity, stimuli-responsiveness, self-assembly, controllable structural transformation, etc.
View Article and Find Full Text PDFBACKGROUND This study aimed to investigate the predictive value of multislice spiral computed tomography (MSCT) perfusion imaging for the efficacy of preoperative concurrent chemoradiotherapy (CCRT) in middle-aged and elderly patients with locally advanced gastric cancer (LAGC). MATERIAL AND METHODS One-hundred twenty-six middle-aged and elderly patients with LAGC were selected. MSCT was performed before and after CCRT to obtain perfusion parameters: blood flow volume (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS).
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