Publications by authors named "Jian-Xiang Song"
Background: Accurate preoperative prediction of lymph node metastasis (LNM) in esophageal cancer (EC) patients is of crucial clinical significance for treatment planning and prognosis.
Aim: To develop a clinical radiomics nomogram that can predict the preoperative lymph node (LN) status in EC patients.
Methods: A total of 32 EC patients confirmed by clinical pathology (who underwent surgical treatment) were included.
Esophageal cancer, also referred to as esophagus cancer, is a prevalent disease in the cardiothoracic field and is a leading cause of cancer-related mortality in China. Accurately determining the status of lymph nodes is crucial for developing treatment plans, defining the scope of intraoperative lymph node dissection, and ascertaining the prognosis of patients with esophageal cancer. Recent advances in diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging (MRI) have improved the effectiveness of MRI for assessing lymph node involvement, making it a beneficial tool for guiding personalized treatment plans for patients with esophageal cancer in a clinical setting.
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- Hypertension causes cardiac remodeling and is linked to a protein called A-kinase anchor protein 12 (AKAP12), which helps regulate blood vessel integrity, but its role in cardiac injury from angiotensin II (Ang II) is not well understood.
- The study found that Ang II infusion lowered AKAP12 levels in wild-type mice, while AKAP12 knockout led to increased inflammation, quicker heart damage, and worsened heart failure symptoms.
- Results indicate that AKAP12 helps protect against fibrosis induced by Ang II, possibly by inactivating the TGF-β1 pathway, as evidenced by various molecular analyses showing increased fibrosis markers in AKAP12-deficient mice.