Publications by authors named "Jian-Wen Xiao"

Article Synopsis
  • Voriconazole (VRZ) has potential drug-drug interactions (DDIs) that can lead to adverse events (AEs), which this study aims to analyze using data from the OpenVigil FDA platform.
  • The study specifically investigates AEs linked to VRZ interactions with proton pump inhibitors, NSAIDs, immunosuppressants, and other antibacterial drugs, using various statistical methods to evaluate these correlations.
  • Out of 38 investigated drugs, 262 AEs were found, with 77 showing significant positive correlations with DDIs, notably highlighting graft-versus-host disease in immunosuppressant interactions and multiple organ dysfunction syndrome with other antibacterials, while also identifying sex and age differences in AEs.
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Objective: To explore the molecular genetic characteristics of children with B-cell acute lymphoblastic leukemia (B-ALL) and the application value of RNA-sequencing (RNA-seq).

Methods: The clinical and laboratory examination data of newly diagnosed B-ALL children who were given treatment in the Department of Hematology, Children's Hospital of Chongqing Medical University from May 2015 to April 2020 were collected and analyzed. All children were confirmed by bone marrow morphology, histochemical staining and flow cytometry, and the karyotype analysis, FISH, RT-PCR and RNA-seq detection were conducted.

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There have been limited studies concerning the safety and efficacy of linezolid (LZD) in children. This study aimed to evaluate the association between LZD exposure and clinical safety and efficacy in Chinese pediatric patients. This retrospective cross-sectional study included patients ≤18 years of age who received ≥3 days of LZD treatment between 31 January 2015, and 31 December 2020.

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Objective: To study the occurrence of serious adverse events (SAEs) related to chemotherapy with CCCG-ALL-2015 regimen in children with acute lymphoblastic leukemia (ALL) and the risk factors for death after the SAEs.

Methods: A retrospective analysis was performed on the medical data of 734 children with ALL. They were treated with CCCG-ALL-2015 regimen from January 2015 to June 2019.

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Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) is a method of retrospective medical record review that measures harm in hospitalized children. We employed a three-stage retrospective chart review of random samples of 1800 pediatric inpatients discharged from January 2013 to December 2015.

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Objective: To investigate the correlation between the expression level of PRPS1 and the clinical characteristics in children with acute leukemia(AL).

Methods: Real-time quantitative RT-PCR and Western blot were used to detect the level of PRPS1 mRNA and protein expression in bone marrow samples from 176 patients diagnosed as AL (126 cases were newly diagnosed and 50 cases in complete remission), and its relevance with clinical indicators was statistically analyzed. The bone marrow samples from 21 children with non-malignant hematological disease were used as controls.

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Objective: To summarize the clinical characteristics, laboratory findings and prognosis of patients with Down syndrome-related acute leukemia (DS-AL).

Methods: The clinical data, laboratory findings, chemotherapy and prognosis of 21 children with DS-AL were analyzed.

Results: Most of the children had disease onset of leukemia at 1 to 5 years of age (85.

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Article Synopsis
  • - The study focused on the prevalence of thalassemia and its genetic variations among children in Chongqing, China, revealing a total carrier frequency of 7.76%.
  • - Among the carriers, 5.20% had α-thalassemia, 1.99% had β-thalassemia, and 0.57% had abnormal hemoglobin variants, with novel mutations identified for the first time in the Chinese population.
  • - The findings indicate a significant risk for α- and β-thalassemia in Chongqing, providing valuable data for genetic counseling and prevention strategies in the region.
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Objective: To investigate the clinical features of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH), to analysis the outcome of HLH-2004 protocol, and to explore the prognostic factors in EBV-HLH patients.

Methods: The clinical features at onset and outcome of HLH-2004 protocol from 83 pediatric patients with EBV-HLH enrolled from January 2006 to December 2009 in our hospital were analyzed retrospectively. Univariate and multivariate COX regression analysis were used to identify statistically significant prognostic factors.

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Objective: To understand the clinical characteristics and outcome associated with respiratory syncytial virus (RSV) infection in hematopoietic stem cell transplantation (HSCT) recipients with primary immunodeficiencies (PIDs).

Method: Nasopharyngeal aspirate samples were collected consecutively before and after HSCT from 9 recipients from Apr. 2009 to Sep.

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Objective: To summarize the clinical characteristics of secondary coagulation disorders caused by exposure to poison (raticide) in children and to investigate the diagnosis and corresponding treatment.

Method: The process of diagnosis, clinical characteristics, response to treatment and the prognosis were analyzed.

Results: The main clinical manifestation was mucosal bleeding (66.

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Objective: Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency diseases. The patients with classical WAS have poor prognosis. The hematopoietic stem cell transplantation is the most effective method to cure WAS at present.

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Objective: The abnormality of hemopoietic inductive microenvironment (HIM) is involved in the pathophysiology of aplastic anemia (AA). Mesenchymal stem cells (MSC) are main source of bone marrow stromal cells which constitute the bone marrow HIM. Thus, the bone marrow failure in AA may be related to the function of MSC.

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