Publications by authors named "Jian-Wei Ku"
Background: The impact of hospital volume on the long-term survival of esophageal squamous cell carcinoma (ESCC) has not been well assessed in China, especially for stage I-III stage ESCC. We performed a large sample size study to assess the relationships between hospital volume and the effectiveness of ESCC treatment and the hospital volume value at the lowest risk of all-cause mortality after esophagectomy in China.
Aim: To investigate the prognostic value of hospital volume for assessing postoperative long-term survival of ESCC patients in China.
Keratin pearls (KP) is an important indicator of the degree of tumor cell differentiation of esophageal squamous cell carcinomas (ESCC). However, the independent prognostic value of KP in ESCC patients remains unclear. The hematoxylin-eosin (H&E) stained tissue microarrays (TMAs) or whole slides of the patients were prepared to identify the existence of KP.
View Article and Find Full Text PDFBackground: In China, it has been well recognized that some female patients with esophageal squamous cell carcinoma (ESCC) have different overall survival (OS) time, even with the same tumor-node-metastasis (TNM) stage, challenging the prognostic value of the TNM system alone. An effective predictive model is needed to accurately evaluate the prognosis of female ESCC patients.
Aim: To construct a novel prognostic model with clinical and reproductive data for Chinese female patients with ESCC, and to assess the incremental prognostic value of the full model compared with the clinical model and TNM stage.
Background: Primary small cell carcinoma of the esophagus (PSCE) is a highly invasive malignant tumor with a poor prognosis compared with esophageal squamous cell carcinoma. Due to the limited samples size and the short follow-up time, there are few reports on elucidating the prognosis of PSCE, especially on the establishment and validation of a survival prediction nomogram model covering general information, pathological factors and specific biological proteins of PSCE patients.
Aim: To establish an effective nomogram to predict the overall survival (OS) probability for PSCE patients in China.
Background: The accumulated evidence has indicated the diagnostic role of cytokeratin (CK) and vimentin protein immunoassay in primary esophageal spindle cell carcinoma (PESC), which is a rare malignant tumor with epithelial and spindle components. However, it is largely unknown for the expression of CK and vimentin in pathological changes and prognosis of PESC.
Methods: Eighty-two PESC patients were identified from the esophageal and gastric cardia cancer database established by Henan Key Laboratory for Esophageal Cancer Research of Zhengzhou University.
Objective: : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 () gene in a Chinese Han population. We also aimed to investigate genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma (ESCC).
Methods: : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China.
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of human papillomavirus (HPV) in esophageal cancer, comparing it to its well-established role in cervical cancer, analyzing 145 esophageal and 143 cervical tissue samples from a high-incidence area in Northern China.
- Researchers found that high-risk HPV types were present in over 90% of the HPV-positive lesions, with a significant increase in prevalence as both esophageal and cervical lesions progressed from normal to cancerous.
- High-risk HPV infection significantly elevated the risk of developing dysplasia and invasive cancer for both esophagus (4-fold increase) and cervix (12 to 20-fold increase), with HPV 16 being the most common subtype detected in both tissue types.
Article Synopsis
- A genome-wide association study was conducted on esophageal squamous cell carcinoma (ESCC) involving 1,077 ESCC patients and 1,733 control subjects, focusing on the Chinese Han population.
- The study successfully replicated findings in larger cohorts, identifying two new genetic risk factors for ESCC: PLCE1 and C20orf54, with strong statistical significance.
- PLCE1 is linked to essential cellular functions like growth and apoptosis, while C20orf54 is involved in riboflavin transport, highlighting their potential roles in ESCC and gastric cardia adenocarcinoma (GCA) risk.