Publications by authors named "Jian-Song Ren"
Background: The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil (5-FU) in advanced-stage gastric cancer is still unelucidated.
Aim: To explore the long-term survival benefit of using sustained-release 5-FU implants in stage II and stage III gastric cancer patients.
Objective: We evaluated and compared the efficacy and safety of neoadjuvant chemoradiotherapy (NACRT) versus neoadjuvant chemotherapy (NACT) for locally advanced gastric cancer (LAGC) in a single-center randomized phase II trial.
Methods: Patients with LAGC were enrolled and received either NACT or NACRT, followed by gastrectomy and adjuvant chemotherapy. The primary endpoint was an R0 resection rate.
Background: Prospective analyses have yet to identify a consistent relationship between sleep duration and the incidence of gastrointestinal (GI) cancers. The effect of changes in sleep duration on GI cancer incidence has scarcely been studied. Therefore, we aimed to examine the association between baseline sleep duration and annual changes in sleep duration and GI cancer risk in a large population-based cohort study.
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- - Lung cancer is the most common cancer and a major cause of cancer deaths in China, prompting a study to assess the direct medical costs associated with its care from 2002 to 2011.
- - The study analyzed data from 15,437 patients across 13 provinces, revealing that the average medical expenditure per lung cancer case in 2011 was 39,015 CNY (about US$6,041), with a 7.55% annual increase over the period.
- - Drug costs constituted the largest share of medical expenses at 54.27%, with treatment and surgical costs following behind; costs varied significantly depending on regional factors and hospital types.
Article Synopsis
- This study focuses on identifying risk factors for gastric cancer (GC) in China to help target high-risk populations for early detection.
- It utilizes data from a national cancer screening program, comparing 215 GC patients to 645 healthy controls matched by age and sex, analyzing various factors like BMI, lifestyle habits, and family medical history.
- Key findings reveal that factors such as low educational level, being overweight, cigarette smoking, alcohol consumption, and a history of stomach diseases or family history of GC significantly increase the risk of developing gastric cancer.
Article Synopsis
- * The average age of diagnosis was 59.3 years, with a notable rise in stage IV diagnoses from 13.5% to 20.5% over the study period; also, there was a shift toward more advanced diagnostic technologies such as CT and MRI, while x-ray usage decreased.
- * Surgical treatments declined, with more patients receiving chemotherapy; average medical costs per patient rose significantly from about 47,259 to 86,709 Chinese
Article Synopsis
- This study examined the health-related quality of life (HRQoL) of colorectal precancer and cancer patients in China, using data collected from a cross-sectional survey conducted from 2012 to 2014 across 12 provinces.* -
- A total of 376 precancer and 2,470 CRC patients participated, with utility scores indicating a significant decline in HRQoL compared to the general population, particularly noting pain and discomfort as major issues.* -
- Multivariate analysis identified various factors influencing utility scores including treatment type, education, income, and geographic location, suggesting the need for tailored interventions and further evaluations in healthcare.*
Background: Chemotherapy has improved the survival of non-small cell lung cancer (NSCLC) patients over the past few decades. However, there have not been any epidemiological studies on chemotherapy for Chinese NSCLC patients.
Patients And Methods: The patients diagnosed as primary lung cancer between January 1, 2005, and December 31, 2014, in eight hospitals from eight provinces in China were retrospectively reviewed.
Article Synopsis
- - The study aims to understand how participation in breast cancer screening programs affects health-related quality of life (HRQoL), with data gathered from a survey across 12 provinces in China.
- - Results showed that while utility scores (a measure of HRQoL) for those in the screening group were lower than those of the general population (0.937 vs. 0.953), issues like pain, discomfort, and anxiety/depression were common in both groups.
- - The findings highlight the need for further research, as utility scores decreased temporarily during screening but indicated potential improvements afterward, suggesting that the difference in scores might not be clinically significant.
Background: Most lung cancer patients are diagnosed after the onset of symptoms. However, whether the symptoms of lung cancer were independently associated with the diagnosis of lung cancer is unknown, especially in the Chinese population.
Methods: We conducted a 10 years (2005-2014) nationwide multicenter retrospective clinical epidemiology study of lung cancer patients diagnosed in China.
Background: Lung cancer is substantially attributable to smoking, but detailed related estimates on smoking-attributable expenditure (SAE) in China are not available yet, which could inform tobacco control and cancer prevention initiatives.
Methods: A prevalence-based approach was adopted to estimate the total SAE, including direct expenditure (medical and non-medical) and indirect cost (disability and premature death). Detailed per-patient data on direct expenditure and work-loss days were acquired from a unique multicentre survey in China.
Objectives: This study aimed to explore the clinical profile and its trajectory of lung cancer on clinicopathological characteristics and medical service utilization in China.
Methods: Patients diagnosed with primary lung cancer in tertiary hospitals during 2005-14 were selected from seven geographic regions of China. Data on clinical characteristics and medical service utilization was extracted from medical record, and the ten-year trends were explored.
Unlabelled: Both polo-like kinase 1 (PLK1) and mammalian/mechanistic target of rapamycin (mTOR) are attractive therapeutic targets for cancer therapy. However, the efficacy of the combined inhibition of both pathways for treating esophageal squamous cell carcinoma (ESCC), an aggressive malignancy with poor prognosis, remains unknown. In this study, we found that suppression of PLK1 by specific siRNA or inhibitor attenuated mTOR activity in ESCC cells.
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- Stomach cancer is a significant health issue in China, ranking as the third most common cancer and a leading cause of cancer deaths, prompting a study on the medical expenses related to treatment.
- A study involving 14,692 patients revealed that medical expenses for the first course of treatment increased from an average of around 20,000 CNY in 2002 to about 43,249 CNY (6851 USD) in 2011, marking an annual increase of 7.4%.
- The rising costs are primarily attributed to longer hospital stays and more treatment episodes, with drug expenses comprising over half of the total medical costs.
Article Synopsis
- - This study focused on assessing the health-related quality of life and utility scores for patients with breast cancer and precancerous lesions in China, an area with limited existing data.
- - Researchers conducted a survey in 12 provinces over two years (2013-2014) using the EuroQol-5-Dimension instrument, which revealed that breast cancer patients reported an average utility score of 0.887, while precancer patients had a score of 0.781, with pain and discomfort being the most significant issues.
- - The findings indicate that utility scores decrease as the severity of breast cancer increases, highlighting the importance of these scores for future cost-utility analyses in the region.
Lung cancer is the commonly diagnosed cancer and one of the most important avoidable causes of death around the world. We conducted the study to investigate the pattern of lung cancer incidence worldwide. Joinpoint analysis was used to extend international lung cancer incidence rates by the latest data from Cancer Incidence in Five Continents over the 35-year period 1973-2007 from 24 populations from Americas, Asia, Europe, and Oceania.
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- - This study investigates liver cancer medical costs in urban China from 2002 to 2011, revealing a significant rise in average treatment expenses from ¥21,950 to ¥40,386 over the decade.
- - An analysis of 12,342 patients shows that pharmaceutical expenses constitute the largest portion of costs, rising from 48.01% to 52.96%, while nursing fees remain minimal at about 1%.
- - The findings indicate that liver cancer imposes a heavy economic burden on families, with early diagnosis and treatment potentially reducing costs; expenditures are notably higher in the eastern region compared to the west and central areas.
Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends.
View Article and Find Full Text PDFAim: We aimed to assess economic burden of breast cancer (BC) diagnosis and treatment in China through a multicenter cross-sectional study, and to obtain theoretical evidence for policy-making.
Methods: This survey was conducted in 37 hospital centers across 13 provinces in China from September 2012 to December 2014. We collected information on the subject characteristics.
Background: The increasing prevalence of colorectal cancer (CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.
Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014.
Background: Primary liver cancer (PLC) is a common cancer worldwide, especially in developing countries. Several previous studies using different datasets have summarized PLC incidence rates and trends in different populations. However, with changes in exposure to risk factors and the implementation of preventive measures, the epidemiology of PLC worldwide may have changed.
View Article and Find Full Text PDFIndex-based dietary patterns and risk of esophageal and gastric cancer in a large cohort study.
Clin Gastroenterol Hepatol
September 2013
Background & Aims: Diet could affect risk for esophageal and gastric cancers, but associations have been inconsistent. The diet is complex, so studies of dietary patterns, rather than studies of individual foods, might be more likely to identify cancer risk factors. There is limited research on index-based dietary patterns and esophageal and gastric cancers.
View Article and Find Full Text PDF[Estimation and prediction for incidence, mortality and prevalence of common gastrointestinal tract cancers in China, in 2008].
Zhonghua Liu Xing Bing Xue Za Zhi
October 2012
Objective: To estimate the incidence, mortality and prevalence of most common gastrointestinal tract cancers (esophageal, gastric and colorectal cancers) in China in 2008 and to predict the related incidence and mortality in the next 20 years.
Methods: Data from 36 Chinese cancer registries and the Third National Death Survey in China (2004 - 2005) were used to estimate the incidence, mortality and 5-year prevalence of esophageal, gastric and colorectal cancers in China in 2008. Mathematical models were used to predict the incidence and mortality of these cancers in the next 20 years.
Linzhou, China has one of the highest rates of esophageal squamous cell carcinoma in the world. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), may have a role in this increased risk. To better understand PAH sources, we measured PAHs in the air and food of 20 non-smokers over multiple days and compared the concentrations with a urinary PAH biomarker, 1-hydroxypyrene glucuronide (1-OHPG).
View Article and Find Full Text PDF[Estimates and prediction on incidence, mortality and prevalence of lung cancer in China in 2008].
Zhonghua Liu Xing Bing Xue Za Zhi
April 2012
Objective: To estimate the incidence, mortality and 5-year prevalence rates of lung cancer in China, in 2008.
Methods: Data from 36 cancer registries and the Third National Death Survey in China (2004-2005) was used to estimate the incidence, mortality and 5-year prevalence rates of lung cancer in China in 2008. Mathematical models were used to predict the lung cancer incidence and mortality rates in the next 20 years.