Transcriptomic decoding of regional cortical vulnerability to major depressive disorder.

Previous studies in small samples have identified inconsistent cortical abnormalities in major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is unclear how genetic risk for MDD is translated into spatially patterned cortical vulnerability. Here, we initially examined voxel-wise differences in cortical function and structure using the largest multi-modal MRI data from 1660 MDD patients and 1341 controls.

Boosting Activity and Selectivity of UiO-66 through Acidity/Alkalinity Functionalization in Dimethyl Carbonate Catalysis.

The acid-base properties of supports have an enormous impact on catalytic reactions to regulate the selectivity and activity of supported catalysts. Herein, a train of Pd-X-UiO-66 (X = NO , NH , and CH ) catalysts with different acidity/alkalinity functional groups and encapsulated Pd(II) species is first developed, whose activities in dimethyl carbonate (DMC) catalysis are then investigated in details. Thereinto, the Pd-NO -UiO-66 catalyst with acidity functionalization exhibits the best catalytic behavior: the DMC selectivity stemmed from methyl nitrite (MN) is up to 68%, the conversion of CO is 73.

[Investigation on current status of infections of soil-borne nematodes in Yunxiao County].

Objective: To understand the endemic situation of soil-borne nematodes and their distribution characteristics, so as to provide the evidence for formulating prevention strategy.

Methods: According to The Survey Program of Important Human Parasitic Diseases in Fujian Province, the survey spots were determined by the stratified cluster randomly sampling method. The eggs of Ascaris lurmbricoides, hookworm and Trichuris trichiura in feces were detected by Kato-Katz technique; the eggs of Enterobius vermnicularis were checked by rectal swabs using transparent adhesive tape.

Highly efficient iridium catalyst for asymmetric transfer hydrogenation of aromatic ketones under base-free conditions.

[reaction: see text] Catalytic systems generated in situ from the chiral PNNP ligands with iridium or rhodium hydride complexes exhibited excellent catalytic activity and good enantioselectivity in the asymmetric transfer hydrogenation of aromatic ketones without added base. The best result was obtained in the IrH(CO)(PPh(3))(3)-ligand 2 catalytic system with up to 99% yield and 97% ee.