Publications by authors named "Jian-Qing Jiang"
Article Synopsis
- - This study investigates the roles of S100A8/A9 and S100A12 in patients with MPO-ANCA-positive vasculitis, focusing on their potential impact on disease progression and severity.
- - Researchers assessed blood and urine levels of these proteins in 42 AAV patients and discovered that higher levels were linked to more severe disease compared to inactive AAV or healthy controls.
- - The findings suggest that S100A8/A9 and S100A12 could be important biomarkers for AAV and may contribute to the disease's development through specific pathways in activated neutrophils.
Severe acute interstitial nephritis induced by valsartan: A case report.
Medicine (Baltimore)
February 2019
Rationale: Angiotensin receptor blocker (ARB) can increase serum creatinine or potassium levels in patients with renal insufficiency, renal artery stenosis, heart failure or hypovolemia, but hardly cause severe kidney injury in patients without any risk factors. A case of severe acute interstitial nephritis (AIN) induced by valsartan was reported here.
Patient Concerns: A 62-year-old female with nausea for 1 month and acute deterioration of kidney function for 2 weeks was admitted.
Article Synopsis
- The case discusses a 64-year-old female patient who initially presented with kidney issues and was found to have ANCA-negative renal-limited vasculitis, later evolving into ANCA-positive vasculitis over 18 months.
- The transformation from ANCA-negative to ANCA-positive vasculitis was confirmed through subsequent kidney biopsies and detection of antibodies, highlighting a potential process known as epitope spreading.
- The patient responded well to glucocorticoid treatment, showed improvement in kidney function with no relapses during a 6-month follow-up, emphasizing the importance of thorough ANCA testing in diagnosis and management.
Aim: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake.
Methods: A total of 257 cases of esophageal squamous cell carcinoma confirmed by histopathological examination were collected. Genotyping of P16, MGMT and HMLH1 was accomplished by methylation-specific polymerase chain reaction (PCR) after sodium bisulfate modification of DNA and the MTHFR C677T genetic polymorphism was detected by PCR- restriction fragment-length polymorphism (PCR-RFLP).
Aim: Chronic kidney disease-mineral and bone disorder (CKD-MBD) has been proposed to be the replacement of renal osteodystrophy by the Organization of Kidney Disease: Improving Global Outcomes since 2005 because the mineral disorder is not confined to the skeleton in CKD. Accordingly, laboratory and imaging tests have been emphasized for the clinical assessment of patients with CKD besides renal biopsy. The objective of the current study was to investigate whether osteoprotegerin (OPG) could be made a useful biomarker for early diagnosis of CKD-MBD.
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