Publications by authors named "Jian-Qi Cai"
Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs.
Invest Ophthalmol Vis Sci
October 2024
Article Synopsis
- The study aims to create induced microglia-like cells (iMG) from stem cells in a controlled environment and enhance their functionality by coculturing them with retinal organoids.
- Researchers established iMG production conditions, stimulated these cells, and compared their characteristics with a standard microglia cell line (HMC3) to understand their immune responses and maturation.
- The results showed that iMG closely resemble primary human microglia in immune functions, and further maturation with retinal organoids (CC-iMG) led to significant improvements in their cellular activities and properties, potentially aiding future research and therapies related to microglial functions.*