Intravitreal conbercept improves outcome of proliferative diabetic retinopathy through inhibiting inflammation and oxidative stress.

Conbercept is a newly-developed anti-vascular endothelial growth factor (VEGF) drug. This study aimed to evaluate the effects of conbercept on inflammation and oxidative response in proliferative diabetic retinopathy (PDR). Morphology changes in retinal microvasculature of PDR patients were determined by optical coherence tomographic angiography (OCTA).

Observation of a topological nodal surface and its surface-state arcs in an artificial acoustic crystal.

Three-dimensional (3D) gapless topological phases can be classified by the dimensionality of the band degeneracies, including zero-dimensional (0D) nodal points, one-dimensional (1D) nodal lines, and two-dimensional (2D) nodal surfaces. Both nodal points and nodal lines have been realized recently in photonics and acoustics. However, a nodal surface has never been observed in any classical-wave system.

Dual-Band Fano Resonance of Low-Frequency Sound Based on Artificial Mie Resonances.

It is reported both experimentally and numerically that dual-band acoustic Fano resonances (AFRs) of low-frequency sound are realized by a compound unit array composed of two types of multiple-cavity unit cells with different inner radii. Eigenmode analyses show that two types of monopolar Mie resonance (MMR) modes can be observed below 650 Hz, which arise from the coupling resonance of the overall structure and the Helmholtz resonance of each resonance cavity, respectively. Based on the MMRs with the out-of-phase characteristic induced by the mutual coupling of the two types of unit cells, the dual-band AFRs, in which the quality factor of the AFR II can exceed 600 when the ratio of the inner radii is closed to 1.

Binary-phase acoustic passive logic gates.

The recent rapid development of acoustic logic devices has opened up the possibilities of sound computing and information processing. However, simultaneous realization of acoustic logic devices with subwavelength size, broad bandwidth and passive structure still poses a great challenge. To overcome it, we propose a subwavelength acoustic logic gate which consists of binary-phase passive unit cells placed into a multi-port waveguide.

The anti-inflammatory and anti-oxidative effects of conbercept in treatment of macular edema secondary to retinal vein occlusion.

To investigate the effects of conbercept on inflammatory and oxidative response in macular edema secondary to retinal vein occlusion (RVO-ME). Retinal microvasculature were detected by optical coherence tomographic angiography (OCTA). The inflammation related factors including prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), prostaglandin F2a (PGF2a), intercellular cell adhesion molecule-1 (ICAM-1) and macrophage inflammatory protein-1 (MIP-1) were determined in human and mice with RVO-ME.

Programmable Coding Acoustic Topological Insulator.

Topological acoustics has recently revolutionized fundamental concepts of acoustic propagation, giving rise to strikingly unique acoustic edge modes immune to backscattering. Despite the rapid progress in this field, simultaneous realization of reconfigurability, intelligentization, and automatic control over acoustic propagation paths is posing a great challenge. This challenge is overcome by proposing the concept of a programmable acoustic topological insulator based on two digital elements "0" or "1," which consist of honeycomb-lattice sonic crystals made of cylindrical rods with different diameters.

[Investigation on infection in liver disease patients in Hangzhou City].

Objective: To understand the infection in liver disease patients in Hangzhou City.

Methods: A total of 1 200 patients with liver diseases were enrolled, including 300 patients with liver cancer, 300 cases with hepatitis B, 300 cases with hepatic fibrosis and 300 cases with fatty degeneration of the liver, while 1 200 healthy people served as controls. The serum anti- IgG and IgM antibodies were detected in the subjects using ELISA assay.

[A sero-epidemiological survey of infections in high-risk populations in Hangzhou City].

Objective: To understand the status of infections and the awareness of toxoplasmosis prevention and control knowledge among high-risk populations in Hangzhou City.

Methods: The serum anti- antibodies were detected in 100 HIV/AIDS patients, 100 cancer patients, 100 pregnant women and 100 healthy controls, and the awareness of toxoplasmosis prevention and control knowledge was investigated using a questionnaire.

Results: The sero-prevalence of infection was 31%, 30% and 21% in HIV/AIDS patients, cancer patients and pregnant women, which was all significantly higher than in healthy controls ( = 14.

Modulating Sound with Acoustic Metafiber Bundles.

Acoustic metamaterials and metasurfaces provide great flexibility for manipulating sound waves and promise unprecedented functionality, ranging from transformation acoustics, acoustic cloaking, acoustic imaging to acoustic rerouting. However, the design of artificial structures with both broad bandwidth and multifunctionality remains challenging with traditional design approaches. Here we present a design and realization of a broadband acoustic metafiber bundle.

Extraordinary acoustic transmission through annuluses in air and its applications in acoustic beam splitter and concentrator.

We report an extraordinary acoustic transmission through two layer annuluses made of metal cylinders in air both numerically and experimentally. The effect arises from the enhancement and reconstruction of the incident source induced by different Mie-resonance modes of the annuluses. The proposed system takes advantages of the consistency in the waveform between the input and output waves, the high amplitude amplification of output waves, and the easy adjustment of structure.