Screening for anti-influenza virus compounds from traditional Mongolian medicine by GFP-based reporter virus.

Introduction: Screening for effective antiviral compounds from traditional Mongolian medicine not only aids in the research of antiviral mechanisms of traditional medicines, but is also of significant importance for the development of new antiviral drugs targeting influenza A virus. Our study aimed to establish high-throughput, rapid screening methods for antiviral compounds against influenza A virus from abundant resources of Mongolian medicine.

Methods: The use of GFP-based reporter viruses plays a pivotal role in antiviral drugs screening by enabling rapid and precise identification of compounds that inhibit viral replication.

Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.

Ethnopharmacological Relevance: Sorbaria sorbifolia (SS) is a traditional Chinese medicine (TCM) that has been employed anti-hepatocellular carcinoma (HCC) for over 2000 years; yet, its underlying mechanism is still not fully understood.

Aim Of The Study: In this study, we evaluated the anti-HCC effect on the freeze-dried powder of the water extract of SS (FDSS) by inhibiting tumor-induced neovascularization, and promoting apoptosis, and elucidated the underlying mechanisms.

Materials And Methods: HCC cell lines (HepG2 and Huh7 cells) and HepG2 xenograft tumors in zebrafish were employed as in vivo and in vitro models, respectively, to evaluate the anti- HCC-indued neovascularization and apoptosis.

Production of an Animal Model of Semi-Yin and Semi-Yang Syndrome with Diabetic Ulcers and Study of Its Pathological and Metabolic Features.

Background: To create an animal model for diabetic ulcers with semi-Yin and semi-Yang (SYSY) syndrome and to study the pathological and metabolic features of SYSY syndrome.

Methods: Firstly, based on the clinical characteristics of the SYSY syndrome of diabetic ulcer, an animal model of diabetic ulcers with SYSY syndrome being full-thickness skin defects was created by injecting streptozotocin (STZ) intraperitoneally, infecting with , and gastrically administering senna. Secondly, the content and distribution patterns of collagen fibers, the expression of neutrophils and macrophage markers, angiogenesis, and the expression of IL-1 and IL-10 in the rats with Yang syndrome, Yin syndrome, and SYSY syndrome of diabetic ulcers at different time points were detected.

Identification of immune-related genes as prognostic factors in bladder cancer.

Bladder cancer is one of the most common cancers worldwide. The immune response and immune cell infiltration play crucial roles in tumour progression. Immunotherapy has delivered breakthrough achievements in the past decade in bladder cancer.

Assessing the prognostic value of stemness-related genes in breast cancer patients.

Breast cancer (BC) is currently one of the deadliest tumors worldwide. Cancer stem cells (CSCs) are a small group of tumor cells with self-renewal and differentiation abilities and high treatment resistance. One of the reasons for treatment failures is the inability to completely eliminate tumor stem cells.

Prognostic value of immune related genes in lung adenocarcinoma.

Lung cancer has the highest incidence and mortality rates of all cancers in China. Immune-related genes and immune infiltrating lymphocytes are involved in tumor growth, and in the past decade, immunotherapy has become increasingly important in the treatment of lung cancer. Using the package, differentially expressed genes and immune-related genes (DEIRGs) were identified in patients with lung adenocarcinoma (LUAD).

Combined PLT and NE to predict the prognosis of patients with locally advanced cervical cancer.

Cervical cancer is one of the most common tumors in women. Neutrophils (NEs) and platelets (PLTs) are components of cells in circulating blood. NEs are one of the components of white blood cells (WBCs), accounting for the vast majority of WBCs, recognized as one of the indicators of inflammation.

Prognostic Values of LDH and CRP in Cervical Cancer.

Purpose: Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.

Patients And Methods: Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group.

Prognostic values of lymphocyte and eosinophil counts in resectable cervical squamous cell carcinoma.

Cervical cancer is one of the leading causes of cancer mortality in women. Peripheral white blood cell parameters such as neutrophil (NE), eosinophil (EO), basophil (BA), as well as lymphocyte (LY) and monocyte (MO), are correlated with tumor outcomes. In total, 110 cervical squamous cell carcinoma patients were recruited in this study.

Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer.

Background: Cervical cancer is one of the leading causes of cancer mortality in women, which seriously threatens the health of women worldwide. Platelet (PLT)-related parameters, including PLT count, mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), are correlated with tumor prognosis.

Methods: In total, 110 patients with cervical carcinoma were recruited in this study.

Design and biomechanical characteristics of porous meniscal implant structures using triply periodic minimal surfaces.

Background: Artificial meniscal implants can be used to replace a severely injured meniscus after meniscectomy and restore the normal functionality of a knee joint. The aim of this paper was to design porous meniscal implants and assess their biomechanical properties.

Methods: Finite element simulations were conducted on eight different cases including intact healthy knees, knee joints with solid meniscal implants, and knee joints with meniscal implants with two types of triply periodic minimal surfaces.

Prognostic Values of Systemic Inflammation Response (SIR) Parameters in Resectable Cervical Cancer.

Background: Cervical carcinoma is the leading cause of cancer mortality in women. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), and albumin-to-globulin ratio (AGR) are indicators of systemic inflammation response correlated with tumor outcomes.

Methods: This study recruited 110 patients with cervical cancer.

Mechanical characterization of 3D printed multi-morphology porous Ti6Al4V scaffolds based on triply periodic minimal surface architectures.

Heterogeneous biomaterials that simultaneously mimic the topological and mechanical properties of nature bone tissues are of great interest in recent years. In this study, multi-morphology porous scaffolds based on the triply periodic minimal surfaces (TPMS) were designed and 3D printed with spatially changing pore patterns. Experiments and numerical analyses were carried out to assess the mechanical properties of the multi-morphology graded porous scaffold.

A new species of genus Thoradonta Hancock, 1908 (Orthoptera: Tetrigoidea: Tetrigidae) from India.

A new species of genus Thoradonta subtruncata sp. nov. is described from Korba, Chhattisgarh, India.

A new species of the genus Tridactylus Olivier, 1789 (Orthoptera, Tridactyloidea, Tridactylidae) from India.

A new species of genus Tridactylus bijakherensis sp. nov. is described from Korba, Chhattisgarh, India, with a key to the Indian species of the genus Tridactylus Olivier, 1789.

Description of a new species of the genus Mongolotettix Rehn, 1928 (Orthoptera: Acrididae) from Fujian, China.

A new species of the genus Mongolotettix Rehn, 1928 from Fujian, China is described in this paper. The new species Mongolotettix.fujianensis sp.

A new species of the genus Xya Latreille, 1809 from China (Orthoptra, Tridctyloidea, Tridactylidae).

A new species of the genus Xya Latreille, 1809 from Sichuan, China is described in this paper. The new species Xya sichuanensis sp. nov.

A new species of the genus Humphaplotropis from China (Orthoptera: Pamphagidae, Pamphaginae).

A new species of the genus Humphaplotropis Xiao et al, 2013, i.e. Humphaplotropis tongbaishanensis sp.

A new species of the genus Latreille, 1809 (Orthoptera, Tridactyloidea, Tridactylidae) from Sichuan, China.

A new species Xya leshanensis sp. nov. of the genus Xya Latreille, 1809 from Sichuan, China is described in this paper.

A new species of the genus Rehn, 1928 from Hubei, China (Acrididae, Acridoidea, Orthoptera).

The genus Mongolotettix Rehn, 1928 is a small genus of family Adrididae. It has nine species discovered from the Far Eastern Asian countries, including China, Japan, Korea, Mongolia, and Russia [Bolívar, 1898; Uvarov, 1914; Caudell, 1921; Chogsomzhav, 1974; Li et Lian, 1994; Wan, Ren et Zhang, 1998; Xie et Li, 2000, Kim et Kim 2005; Dong, et al, 2015; Shi et al, 2016; Storozhenko, 2016; Eades et al, 2017; Zhang et al, 2017]. In the present paper, we describe a new species of the genus from Hubei, China.

Two new species of the genus Sinopodisma Chang, 1940 (Orthoptra, Acridoidea, Catantopidae, Podisminae) from Taiwan, China.

Two new species of the genus Sinopodisma Chang, 1940 from Taiwan, China are described in this paper. The new species Sinopodisma orchofemura sp. nov.

Two new species of the genus Fieber, 1852 (Orthoptera: Oedipodidae) from China.

Two new species of the genus Sphingonotus Fieber, 1852, namely Sphingonotus taiwanensis sp. nov. and Sphingonotus zhongningensis sp.

Hedotettix angulatus sp. nov. (Orthoptera: Tetrigoidea:Tetrigidae, Tetriginae) a new pygmy grasshopper species from India.

Hedotettix angulatus sp. nov. is described from Chhattisgarh, India.

A review of the genus Eotmethis (Orthoptera, Acridoidea, Pamphagidae) with two new species and key to known species of the genus from China.

Two new species of the genus Eotmethis Bey-Bienko, 1948, namely Eotmethis inditibialis sp. nov. and Eotmethis shizuishanensis sp.