Publications by authors named "Jian-Pao Cai"
Mycolyltransferase is important for biofilm formation and pathogenesis of keratitis.
Emerg Microbes Infect
December 2024
Article Synopsis
- A group of multi-drug resistant bacteria is linked to bacterial eye infections such as conjunctivitis and keratitis, but details on how these infections develop are not well understood.
- A study using New Zealand White rabbits established a model to investigate how biofilm formation by these bacteria contributes to keratitis, leading researchers to explore gene sequences for potential virulence factors involved in this process.
- The identification of a gene encoding a mycolyltransferase was found to play a significant role in the infection, indicating that targeting this gene could offer new treatment options for ocular infections.
Recently, we showed that Mp1p is an important virulence factor of Talaromyces marneffei, a dimorphic fungus phylogenetically closely related to Aspergillus fumigatus. In this study, we investigated the virulence properties of the four Mp1p homologues (Afmp1p, Afmp2p, Afmp3p, and Afmp4p) in A. fumigatus using a mouse model.
View Article and Find Full Text PDFBackground: Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei.
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