Publications by authors named "Jian-Ning Zhu"
Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer.
Comb Chem High Throughput Screen
February 2020
Background: Adenosine deaminase (ADA) is an important enzyme in purine metabolism and is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Traditional Chinese Herbal Medicine (TCHM) is widely used alone or in combination with chemotherapy to treat cancer, due to its ability to deliver a broad variety of bioactive secondary metabolites as promising sources of novel organic natural agents.
Objective: In the present study, 29 varieties of medicinal plants were screened for the presence of ADA inhibitors.
[DAB2IP expression in bladder transitional cell carcinoma and its correlation with clinical outcome].
Sichuan Da Xue Xue Bao Yi Xue Ban
July 2014
Article Synopsis
- The study aimed to examine the levels of DAB2IP protein in bladder transitional cell carcinoma (BTCC) and its relation to clinical features and patient prognosis.
- It used immunohistochemical staining on tissue samples from 79 BTCC cases and 11 normal bladder cases, analyzing the connection between DAB2IP levels and factors like cancer stage, grade, and survival rates.
- Results showed that lower DAB2IP expression in BTCC tissue correlated with higher grade and metastasis, and patients with higher DAB2IP levels had better 3-year survival rates, suggesting DAB2IP is crucial in inhibiting BTCC progression.
Hypoxia is a characteristic feature of solid tumors, leading to malignant behavior. During this process, HIF family members (HIFs) and the NF-κB pathway are activated. In addition, the hypoxia-associated factor (HAF) is reported to participate in the regulation of HIFs.
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