Publications by authors named "Jian-Min Gu"
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer partly driven by cancer stem cells (CSCs), and targeting the factors that contribute to CSC resilience, such as NR5A2, is critical for improving treatment options.
- *In research using patient-derived PDAC models, it was found that NR5A2 promotes cell growth in regular cancer cells and enhances stemness in CSCs by influencing key genes and metabolic pathways.
- *Importantly, the NR5A2 inhibitor Cpd3 was shown to make PDAC cells more sensitive to chemotherapy, leading to better treatment outcomes and the potential for long-term survival, with NR5A2/SOX2 levels serving as a predictor for treatment response
Design, synthesis and antitumor activity of aromatic urea-quinazolines.
Future Med Chem
November 2019
Gefitinib and sorafenib have been proved effective for the treatment of cancers in clinical practice for years. We intended to integrate the structural features of gefitinib and sorafenib and construct structurally unique 7-aromatic ureido-4-anilinoquinazolines. Most of the targets exhibited promising antitumor activities.
View Article and Find Full Text PDF[The radiosensitization of nimotuzumab on CAL-27 cells after I seeds irradiation].
Shanghai Kou Qiang Yi Xue
August 2016
Purpose: To observe the inhibitory effect of nimotuzumab combined with low-dose continuous irradiation using I seeds on CAL-27 cells originating from human tongue squamous carcinoma, and explore the radiosensitization of nimotuzumab on human tongue squamous carcinoma CAL-27 irradiated with I seeds.
Methods: The exponential-phase CAL-27 cells were randomly divided into 4 groups: control group, I seeds irradiation group, nimotuzumab group, nimotuzumab plus I seeds irradiation group. CCK-8 assay was used to detect the inhibitory effect of I seeds irradiation on CAL-27 cancer cells, and flow cytometry assays were performed to calculate the apoptosis rate of cells and cell cycle from each group.
[Thoracoscopic cardiac surgical procedures: a report of 674 cases].
Zhonghua Wai Ke Za Zhi
November 2007
Objective: To evaluate the efficacy and safety of thoracoscopic cardiac surgical procedures under extracorporeal circulation.
Methods: From May 2000 to May 2006, 674 patients received thoracoscopic cardiac surgery under extracorporeal circulation. These procedures included atrial septal defect occlusion for 238 patients, ventricular septal defect occlusion for 380 patients and mitral valve replacement for 56 patients.