[Relationship between NLRP1 and Liver Dysfunction Following Allogeneic Hematopoietic Stem Cell Transplantation].

Objective: To explore the effect of NLRP1 on the liver dysfunction following allogeneic hematopoietic stem cell transplantation(allo-HSCT).

Methods: The mouse model of allo-HSCT was established by using C57BL/6 and NLRP mice were used as the recipients: BABL/c mice were used as donors). The chimera rates of donor's bone marrow cells were assayed by flow cytometry.

Clinico-hematological profile and thrombotic/hemorrhagic events in 150 chinese patients with essential thrombocythemia.

Essential thrombocythemia (ET) is an uncommon chronic myeloproliferative disorder with no cure. Patients with ET are at risk of different complications, and currently there are no optimal prognostic standards to predict severe post-diagnosis complications such as thrombosis and hemorrhage. In this study, we retrospectively analyzed the full set of clinical data from 150 Chinese patients with ET enrolled from 2013 to 2016.

[Advances of Studies on Platelet GPVI as Antithrombotic Target -Review].

Platelet activation is a crucial step in both physiological hemostasis and pathological thrombosis, which is an important mean to prevent and treat thrombotic diseases by inhibition of platelet activation. The current clinical antithrombotic therapy showed a high efficiency, but at risk of bleeding. Platelet glycoprotein VI (GPVI) is a platelet-specific receptor and its binding with collagen is critical for platelet activation.

[Research Progress on Roles of Platelets in Tissue Repair -Review].

Platelets are known to play a critical role in thrombosis and hemostasis. However, recent studies demonstrated that beyond their role in thrombosis and hemostasis, platelets are also involved in the regulation of tissue repair and regeneration. Increasing number of studies on the roles of platelets in tissue repair showed that various growth factors, chemokines as well as cytokines secreted from activated platelets regulate injured tissue repair and regeneration with the main mechanisms being through regulation of cell migration, proliferation, and angiogenesis, cell apoptosis and survival.

Stromal cells attenuate the cytotoxicity of imatinib on Philadelphia chromosome-positive leukemia cells by up-regulating the VE-cadherin/β-catenin signal.

β-Catenin is a key regulator of leukemia stem cell maintenance and drug resistance. Herein, we investigated the protective effects of the stromal cell-mediated VE-cadherin-β-catenin signal on Ph+ leukemia cells during imatinib treatment. We found stromal cells could desensitize imatinib and up-regulate VE-cadherin expression on Ph+ leukemia cells (K562 and SUP-B15 cells), which further stabilized and activated β-catenin.

Elevated levels of T-cell immune response cDNA 7 in patients with immune thrombocytopenia.

Objectives: This study aimed to investigate the expression levels of T-cell immune response cDNA 7 (TIRC7) in immune thrombocytopenia (ITP) patients before and after high-dose dexamethasone (HD-DXM) treatment.

Methods: Forty-four patients with ITP were enrolled and received dexamethasone (40 mg/day) for 4 consecutive days. Patients who had platelet counts more than 50 × 10(9)/l or less were defined as responders or non-responders, respectively.