Publications by authors named "Jian-Li Ni"

Background: This study aimed to explore the clinical efficacy of Chaihu Shugan powder combined with acupoint stimulation on the acute pancreatitis of liver and qi stagnation syndromes, the protection of intestinal barrier function, the prevention of severe tendency, and safety evaluation.

Method: Data were collected from October 2019-June 2021 at Xinhua Hospital, which is affiliated with Shanghai Jiao Tong University School of Medicine, Emergency Department. Eighty patients with acute pancreatitis were randomly divided into a control treatment group (40 people) and a combined traditional Chinese medicine (TCM) treatment group (40 people).

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Aim: Hypertensive nephropathy is embodied by kidney tissue fibrosis and glomerular sclerosis, as well as renal inflammation. The Hippo/YAP (yes-associated protein, YAP) axis has been reported to promote inflammation and fibrosis and may participate in the pathogenesis of heart, vascular and renal injuries. However, the role of the Hippo/YAP pathway in hypertensive renal injury has not been reported so far.

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Article Synopsis
  • The study investigates how traditional Chinese medicine (TCM) is used to treat acute pancreatitis (AP) over the last 20 years, utilizing machine learning and AI for analysis.
  • Researchers compiled a dataset of 516 TCM compounds, using 90% for training a random forest model to predict the efficacy of these prescriptions against AP.
  • Key findings reveal that rhubarb and Rhizoma Corydalis are notably effective, with the model achieving an R-squared score of 0.8021, indicating a strong predictive performance for TCM treatments.
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To investigate the role played by gut microbiota in the development and treatment of acute pancreatitis. Gut microbiota is the largest micro-ecosystem in the human body, and is related to various system diseases. Acute pancreatitis is one of the common acute critical diseases in clinical practice, and there are various causative factors for the occurrence of this disease, such as alcohol, infection, obstruction and intestinal microecological factors.

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Compound traditional Chinese medicine database was established by collecting 176 compound formulas for dysmenorrhea in the last twenty years. The proportion and frequency of herbal medicine were analyzed and the main herbs with mono-target or multi-target in the compound formulas were selected with simple and multiple linear regression. The linear regression equations were listed and the clinical effects of the compound formulas were evaluated.

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