Exploring ALK fusion in colorectal cancer: a case series and comprehensive analysis.

Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and safety of ALK inhibitors (ALKi) in CRC remain undetermined. Herein, we examined a series of ALK-positive CRC patients who underwent various lines of ALKi treatment.

Node Deployment of Marine Monitoring Networks: A Multiobjective Optimization Scheme.

The increasing demands for real-time marine monitoring call for the wide deployment of Marine Monitoring Networks (MMNs). The low-rate underwater communications over a long distance, long propagation delay of underwater acoustic channel, and high deployment costs of marine sensors in a large-scale three-dimensional space bring great challenges in the network deployment and management of MMN. In this paper, we first propose a multitier, hierarchical network architecture of MMN with the support of edge computing (HMMN-EC) to enable efficient monitoring services in a harsh marine environment, taking into consideration the salient features of marine communications.

Efficacy of cystectasia in the treatment of ketamine-induced bladder contracture.

Background: The treatment of ketamine-induced bladder contractures remains poorly studied. We therefore evaluated the efficacy of cystectasia with a sodium hyaluronate balanced solution in this kind of bladder contracture.

Methods: Eighteen patients presenting with ketamine-induced bladder contracture between July 2010 and February 2018 were selected and analysed.