Genome-Wide Search Links Senescence-Associated Secretory Proteins With Susceptibility for Coronary Artery Disease in Mouse and Human.

Advanced age is an independent risk factor for coronary artery disease (CAD), the leading global cause of mortality. Senescent vascular cells in the atherosclerotic plaques exhibit senescence-associated secretory phenotype (SASP). How SASP contributes to atherosclerosis and CAD, however, remains unclear.

Preliminary study on lyrics intelligibility at different pitches in Chinese vocal music.

There is still no clear experimental data on the relationship between the intelligibility of Chinese vocal lyrics and different pitch. This study aims at investigating the intelligibility of Chinese sung words at different pitch. A word list is created and sung by eight singers at five different pitches (C5, F4, bB4, bE5, and bA5).

mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease.

This study explored the effects of mammalian target of rapamycin (mTOR) on the increased risk of developing Alzheimer's disease (AD) in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley rats were randomly divided into four groups: control, T2DM, AD and T2DM+AD. Changes in the learning and memory abilities of the rats were observed using the Morris water maze.

[Anterior cervical discectomy and fusion in the treatment of Hangman's fracture].

Objective: To evaluate the efficacies and features of treating Hangman's fracture by anterior cervical discectomy and fusion (ACDF).

Methods: Since June 2005 to December 2008, 36 cases with Hangman's fracture were analyzed with their clinical data including history, symptoms, signs, radiological findings and treatments. According to the classification system designed by Levine and Edwards depending on the radiological manifestations of Hangman's fractures, they were subdivided into type I (n = 9) (conservative therapy), type II (n = 17) and type IIA (n = 10).

Hierarchical structure analysis describing abnormal base composition of genomes.

Abnormal base compositional patterns of genomic DNA sequences are studied in the framework of a hierarchical structure (HS) model originally proposed for the study of fully developed turbulence [She and Lévêque, Phys. Rev. Lett.