Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis.

Background: The objectives of this study were to identify hub genes and biological pathways involved in lung adenocarcinoma (LUAD) bioinformatics analysis, and investigate potential therapeutic targets.

Aim: To determine reliable prognostic biomarkers for early diagnosis and treatment of LUAD.

Methods: To identify potential therapeutic targets for LUAD, two microarray datasets derived from the Gene Expression Omnibus (GEO) database were analyzed, GSE3116959 and GSE118370.

Tibetans retained innate ability resistance to acute hypoxia after long period of residing at sea level.

Could the intrinsic characteristics of tolerance to hypoxia be retained in Tibetan high-altitude natives after they had migrated to a low altitude? To answer this question, we undertook a study of 33 healthy male adolescent Tibetans born and raised in a high plateau (3,700 m [12,140 ft] above sea level) who migrated to Shanghai (sea level) for 4 years. Ten age-matched healthy male Han adolescents born and raised in Shanghai were regarded as the control group. Acute hypoxia was induced in a hypobaric chamber for 2 h to simulate the 3,700 m altitude.