Dual drive coexistence of rearrangement and mutation advanced lung adenocarcinoma and response to crizotinib.

Chromosomal translocation resulting in the fusion between the echinoderm microtubule-associated protein-like 4 () gene and the anaplastic lymphoma kinase () gene has been considered as a novel oncogenic fusion in a subset of non-small cell lung cancer (NSCLC), mostly in non-smokers with adenocarcinoma. EML4-ALK translocations are commonly reported to be mutually exclusive with epidermal growth factor receptor (EGFR) or KRAS mutations. Herein, we reported a rare case of 47-year-old female was diagnosed with lung adenocarcinoma and treated with three cycles of chemotherapy.

Imaging findings of gastric plexiform fibromyxoma with a cystic change: A case report and review of literature.

Rationale: Plexiform fibromyxoma (PF) is an extremely rare mesenchymal tumor of the stomach, and its radiological findings have not been well described. Here, we analyzed the imaging features of a case of PF. To our knowledge, this is a rare reported case with a remarkable cystic change in the imaging literature.

Dual drive coexistence of EML4-ALK and TPM3-ROS1 fusion in advanced lung adenocarcinoma.

We report a case of concomitant EML4-ALK and TPM3-ROS1 fusion in non-small cell lung cancer (NSCLC) in a 47-year-old Chinese man and review the clinical characteristics of this type double of fusion. The patient presented with a local tumor of the left upper lobe and underwent thoracoscopy. Postoperative surgical pathologic staging revealed T N M stage IA.

Concurrent ROS1 gene rearrangement and KRAS mutation in lung adenocarcinoma: A case report and literature review.

Lung adenocarcinomas with gene rearrangement in the receptor tyrosine kinase ROS1 have emerged as a rare molecular subtype. Although these lung adenocarcinomas respond to ROS1tyrosine kinase inhibitors, many patients ultimately acquire resistance. ROS1gene rearrangement is generally mutually exclusive with other driver genomic alterations, such as those in EGFR, KRAS, or ALK, thus multiple genomic alterations are extremely rare.

Impact of Abdominal Shape on Short-Term Surgical Outcome of Laparoscopy-Assisted Distal Gastrectomy for Gastric Cancer.

Background: Laparoscopy-assisted distal gastrectomy (LADG) has been widely accepted for the treatment for gastric cancer. The aim of the present study was to explore the impact of abdominal shape parameters on gastric antrum cancer patients' short-term surgical outcomes of LADG with D2 lymph node dissection in both genders, including the number of lymph nodes retrieved and surgical safety index.

Methods: This was a retrospective analysis of 177 gastric antrum cancer patients, who underwent LADG between April 2009 and January 2016.

Infant pleuropulmonary blastoma: report of a rare case and review of literature.

In infants, pleuropulmonary blastoma is a rare but aggressive tumor. The typical histopathological presentation includes the aggregation of malignant primitive small cells, usually observed in sheets. So as to provide proper and timely treatment, the differential diagnosis includes pulmonary blastoma, sarcomatoid mesothelioma, fetal rhabdomyoma, synovial sarcoma, and primitive neuroectodermal tumor.

Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii.

One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M.

Imaging findings of primary gastric plasmacytoma: a case report.

Primary gastric plasmacytoma (GP) is a rare extramedullary plasmacytoma with clinical and imaging features that are common among other gastric tumors, such as gastric adenocarcinomas, gastric stromal tumors, and lymphomas. Here, we present a histologically confirmed case of primary GP examined with biphasic computed tomography (CT), magnetic resonance imaging (MRI), and endosonography. A well-circumscribed extraluminal mass appearing as homogeneous attenuation/intensity with gradual enhancement was identified on biphasic enhancement CT and MRI.

[Chemical constituents of Euphorbia sikkimensis].

Sixteen compounds were isolated from the aerial parts of Euphorbia sikkimensis by means of various chromatographic techniques such as silica gel, Sephades LH-20 and RP-18, and their structures were elucidated as naringenin (1), kaempferol (2), quercetin (3), kaempferol-3-O-alpha-L-arabinopyranoside (4), quercetin-3-O-alpha-L-arabinopyranoside (5), quercetin-3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6,22-dien-3beta-ol (7), stigmast-5-ene-7-one-3beta-ol (8), 3beta-hydroxy4a, 14alpha-dimethyl-5alpha-ergosta-8, 24(28)-dien-7-one(9), beta-sitosterol (10) , 10-cucurbitadienol( 1) , scopoletin(12) , ethyl gallate(13), p-hydroxybenzaldehyde (14), 3 betahydroxybenzeneethanol( 15) ,and 2,4-dihydroxy-6-methoxy-acetophenone (16) on the basis of spectroscopic data analysis. All the compounds are isolated from this plant for the first time, and compounds 1, 4-8, 15 are obtained from Euphorbia species for the first time.

Spatial-temporal variations of Schistosoma japonicum distribution after an integrated national control strategy: a cohort in a marshland area of China.

Background: Schistosomiasis transmission is typically focal. Understanding spatial variations of Schistosoma infections and their associated factors is important to help to invent site-specific intervention strategies.

Methods: A five-year longitudinal study was carried out prospectively in 12 natural villages, Guichi district of Anhui province.

An integrated strategy for transmission control of Schistosoma japonicum in a marshland area of China: findings from a five-year longitudinal survey and mathematical modeling.

In 2004 an aggressive plan was instituted aiming to achieve nationwide transmission control of schistosomiasis by 2015. Here, we report a longitudinal study on the control of schistosomiasis in Anhui province, China. Using a mathematical model, we compared the effects of different control strategies implemented in the study area.

Effect of habitat fragmentation on the schistosome-transmitting snail Oncomelania hupensis in a mountainous area of China.

The effect of habitat fragmentation on schistosome-transmitting snails was assessed in an intervention village and a control village in Sichuan Province, China. Snail habitats were fragmented by environmental management. After 2 years, the proportions of quadrats with snails in the fragmented habitats decreased from 9.

[Sequencing on products of Oncomelania hupensis through simple sequence repeat anchored polymerase chain reaction amplification].

Objective: To analyze the sequence of microsatellite and the flanking sequence from four populations of Oncomelania hupensis.

Methods: We cloned 159 SSR-PCR amplification products of a commonly used primer, (CA)(8RY), using O. hupensis genomic DNA as template, and sequenced 82 products.

A longitudinal study of comparison of the Kato-Katz technique and indirect hemagglutination assay (IHA) for the detection of schistosomiasis japonica in China, 2001-2006.

From 2001 to 2006, about one-third of the residents aged 5-65 years were selected as the subjects in a schistosome-endemic village located in Jiangxi Province, China. Every 1 year, all participants were analyzed by the Kato-Katz parasitologic examination and indirect hemagglutination assay (IHA). Statistical analysis of the results showed the k indices ranged from 0.

[Spatial distribution pattern of Oncomelania hupensis population in marshland and lake area].

Objective: To explore the spatial pattern of the distribution of Oncomelania hupensis population in marshland and lake region.

Methods: Four bottomlands were selected randomly for the investigation along the Qiupu River in Guichi District, Anhui Province. The quadrats were placed randomly for snail survey, and the mean crowding, mean density, aggregation indices (diffusion coefficient (C), morisita index (Idelta), index of patchiness (m*/m) ), Taylor's power law and Iwao's m*-m regression index were analyzed.

[Genetic diversity in 19 Chinese populations of Oncomelania hupensis (Gastropoda: Rissooidea) detected by simple sequence repeat-anchored polymerase chain reaction amplification].

Objective: To explore the genetic diversity among populations of Oncomelania hupensis.

Methods: Simple sequence repeat-anchored PCR method was used to amplify the genomic DNA of nineteen snail populations from 8 provinces, and the genetic diversities among these snail populations were analyzed.

Results: The genetic distance D among nineteen snail populations ranged from 0 to 0.

[Correlates of and willingness to participate in HIV voluntary counseling and testing among migrants in a city of Shanxi province].

Objective: To determine the correlates of and willingness to participate(WTP) in HIV voluntary counseling and testing (VCT) among migrants in Shanxi province.

Methods: Through quota sampling, a total of 1280 migrants were recruited from 6 different venues where migrants were most likely employed to administer a face-to-face anonymous interview.

Results: Knowledge of VCT among migrants was low.

Field comparison of immunodiagnostic and parasitological techniques for the detection of Schistosomiasis japonica in the People's Republic of China.

A total of 1,811 individuals from two villages located in the areas of China endemic for Schistosoma japonicum were analyzed by the Kato-Katz parasitologic examination, indirect hemagglutination assay (IHA), and enzyme-linked immunosorbent assay (ELISA). Statistical analysis of the results showed the kappa indices ranged from 0.106 to 0.

[Study on the genetic diversity among populations of schistosome intermediate hosts within Oncomelania hupensis (Gastropoda: Rissooidea) in Mainland China].

Objective: To explore the genetic diversity among populations of Oncomelania hupensis.

Methods: Amplified fragment length polymorphism method was used to amplify the genomic DNA pools of twenty five snail populations from ten provinces, and the genetic diversities among these snail populations were analyzed.

Results: The coefficient rates of similarity (GS(DICE)) among twenty five snail populations were ranged was from 0.

[Analysis of genetic diversity of AFLP marker among populations of Oncomelania hupensis].

Objective: To explore the degree of genetic diversity among populations of Oncomelania hupensis.

Methods: AFLP method was used to amplify the genomic DNA of thirteen snail populations from nine provinces (i. e.

[National surveillance of schistosomiasis in China from 2000 to 2004].

Objective: To specify the trends of endemic situation among twenty one national surveillance sites for schistosomiasis from 2000 to 2004.

Methods: According to the national surveillance protocol, longitudinal surveillance on endemic situation of schistosomiasis was carried out at twenty-one sites since 2000.

Results: The infection rate of Schistosoma japonicum declined in six of the twenty-one surveillance sites.

[Appropriate sample size and molecular marker loci in the study of genetic diversity of Ocomelania hupensis].

Objective: To explore the reasonable sample size and the number of molecular marker loci in the study of amplified fragment length polymorphism (AFLP) being used to analyze the genetic diversity of Ocomelania hupensis.

Methods: The ribbed-shelled snails coming from Yueyang, Hunan province, were selected to analyze the relationship of the number of AFLP molecular marker loci and sample size with the reliability of information on genetic variation for Ocomelania hupensis by AFLP method.

Results: Correlations found among the numbers of AFLP molecular marker loci and the sample size with reliable information on genetic variation for Ocomelania hupensis.

[Linking quantitation of electrophoresis pattern and data analysis in AFLP for Oncomelania hupensis].

Objective: To search into a method for analyzing the quantitative data in amplified fragment length polymorphism (AFLP) electrophoresis.

Methods: Oncomelania snails collected from the field were screened. Forty snails found uninfected with schistosomiasis were divided randomly into two groups and used to isolate genomic DNA.