Publications by authors named "Jian-Gang Wu"
Objective: We compared the immunologic characteristics of mycoplasma pneumoniae-triggered Kawasaki disease (MP-KD) with Kawasaki disease (KD) not associated with mycoplasma pneumoniae (MP), with mycoplasma pneumoniae-triggered Henoch-Schönlein purpura (MP-HSP), and with healthy controls.
Methods: Complement levels, cellular and humoral immunity were assessed in KD, in MP-KD, in MP-HSP, and in healthy children.
Results: Of 622 children with KD, 74 had MP-KD.
Article Synopsis
- - The study investigated the link between streptococcal infections and childhood Henoch-Schönlein purpura (HSP) in China over five years, finding that 15.1% of HSP cases were triggered by group A β-hemolytic streptococcus (GABHS).
- - Children with GABHS-triggered HSP had similar epidemiological features to those with HSP alone, but exhibited a significantly higher frequency of kidney issues.
- - The presence of GABHS infection was associated with increased levels of IgA and IgG, while C3 and C4 levels decreased, suggesting that the infection may worsen immune dysfunction and prolong HSP duration.
Epidemiology and Clinical Characteristics of Henoch-Schönlein Purpura Associated with Epstein-Barr Virus Infection.
Mediterr J Hematol Infect Dis
November 2021
Article Synopsis
- Henoch-Schönlein purpura (HSP) is a type of vasculitis linked to the immune response, potentially triggered by Epstein-Barr virus (EBV) infection.
- A five-year study showed that 4.2% of HSP cases were EBV-related, with these cases experiencing significantly more abdominal pain compared to other triggers.
- The study found notable differences in immune markers between EBV-infected patients and healthy controls, suggesting both cellular and humoral immunity play a role in the development of EBV-triggered HSP.