Publications by authors named "Jian-Gang Long"
Article Synopsis
- The study investigates whether maternal homocysteine levels and specific genetic variants (MTHFR and MTRR) influence the likelihood of fetal aneuploidy (abnormal number of chromosomes).
- It involves 619 mothers of aneuploid fetuses and 192 control mothers, analyzing differences in genetic polymorphisms and homocysteine concentrations.
- Findings indicate that certain MTHFR and MTRR genetic variations are linked to specific types of fetal aneuploidies, with higher maternal homocysteine levels associated with increased risk for several trisomies and Turner syndrome.
Dietary restriction has been well-described to improve health metrics, but whether it could benefit pathophysiological adaptation to extreme environment, for example, microgravity, remains unknown. Here, we investigated the effects of a daily rhythm of fasting and feeding without reducing caloric intake on cardiac function and metabolism against simulated microgravity. Male rats under ad libitum feeding or time-restricted feeding (TRF; food access limited to 8 hours every day) were subjected to hindlimb unloading (HU) to simulate microgravity.
View Article and Find Full Text PDFBackground: Congenital heart defect (CHD) is one of the most common birth defects in the world. The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD. However, the correlations between the two genes and fetal CHD were inconsistent in various reports.
View Article and Find Full Text PDFROS, identified as signaling molecules, are responsible for maintaining redox homeostasis in vivo. Appropriate exercise promotes the generation of physiological ROS, enhances the antioxidative potential, promotes exercise performance, and improves metabolism, as well as retards aging and related diseases; whereas overload exercise causes excess ROS, resulting in exercise-induced fatigue or even exercise-induced injury. Mitochondria are the main pool of ROS production and act as the key organelles in modulating intracellular redox homeostasis.
View Article and Find Full Text PDFObjective: To study the effect of zinc on mRNA expression of ZIP4 in human intestinal Caco2 cells and its regularity.
Methods: Low zinc cell model was established by TPEN, a kind of chelating agent which chelates specially to zinc. ZIP4 cDNA fragment was obtained by RT-PCR.