Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy (NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial.

Objective: To investigate whether the combination of chemotherapy with staged Chinese herbal medicine (CHM) therapy could enhance health-related quality of life (QoL) in non-small-cell lung cancer (NSCLC) patients and prolong the time before deterioration of lung cancer symptoms, in comparison to chemotherapy alone.

Methods: A prospective, double-blind, randomized, controlled trial was conducted from December 14, 2017 to August 28, 2020. A total of 180 patients with stage I B-IIIA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM (chemo+CHM) group (120 cases) or chemotherapy combined with placebo (chemo+placebo) group (60 cases) using stratified blocking randomization.

Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient.

The risk of developing hepatocellular carcinoma (HCC) is strongly associated with hepatitis B virus infection. Hepatic angiomyolipoma (AML), a rare benign tumor, is composed of a heterogeneous mixture of adipose cells, smooth muscle cells and blood vessels. Here, we report the case of a 44-year-old man who developed HCC with a concomitant hepatic AML and a cavernous hemangioma, in the absence of cirrhosis.

Different behaviors in the transformation of PATP adsorbed on Ag or Au nanoparticles investigated by surface-enhanced Raman spectroscopy - a study of the effects from laser energy and annealing.

In order to explore the key role of surface plasmon resonance (SPR) and active (3)O2 for the chemical transformation to 4,4-dimercaptoazobenzene (DMAB) from p-aminothiophenol (PATP) adsorbed on Ag or Au NPs, we systematically investigated the laser wavelength and temperature dependent surface-enhanced Raman spectra of PATP capped Ag and Au NPs. DMAB can be easily observed at the 514.5nm laser for Ag NPs but at the 632.

Laser-induced chemical transformation of PATP adsorbed on Ag nanoparticles by surface-enhanced Raman spectroscopy-a study of the effects from surface morphology of substrate and surface coverage of PATP.

The laser induced transformation of p-aminothiophenol (PATP) to p,p'-dimercaptoazobenzene (DMAB) has attracted intensive interest recently, in which localized surface plasmon resonance (LSPR) assisted photocatalysis has been demonstrated to play an important role. In this paper, we systematically investigate the factors that influence the reaction for further understanding the mechanism using surface-enhanced Raman spectroscopy. The laser-induced formation of DMAB was found to depend on the surface coverage of PATP, the aggregation state of NPs, and the laser power.

Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers.

To investigate the effects of hypoxic exercise training on microRNA (miRNA) expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group (N, n=10) and a hypoxic exercise training group (H, n=10). After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of peroxisome proliferator activated receptor α (PPARα), fatty acid synthetase (FAS), and carnitine palmitoyl transferase 1A (CPT1A) in rat liver. Body weight, Lee's index, fat mass, fat/weight ratio, and serum levels of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were all significantly lower in the H group than in the N group (P<0.

Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer.

Despite recent advances in the management of non-small cell lung cancer (NSCLC), the prognosis of NSCLC is still relatively poor. Thus, it is of great importance to identify novel effective diagnostic and prognostic biomarker of NSCLC. A growing volume of literature has demonstrated the vital roles of long non-coding RNAs (lncRNAs) in cancer biology.

Etoposide-cisplatin alternating with vinorelbine-cisplatin versus etoposide-cisplatin alone in patients with extensive disease combined with small cell lung cancer.

Background: The aim of this study was to evaluate the efficacy of alternating etoposide-cisplatin and vinorelbine-cisplatin (EP-NP) compared with an etoposide-cisplatin (EP) regimen for advanced combined small cell carcinomas.

Materials And Methods: Histologically confirmed combined small cell carcinoma patients who met the inclusion criteria were randomly assigned (1:1) into either the EP-NP setting (group A) or the EP setting (group B). The primary endpoint was progression-free survival in patients who received at least one dose of treatment.

[A cross-sectional survey on the prevalence of Brucellosis among workers in Jiangsu province, 2012].

Objective: To study the status of infection and risk factors on Brucellosis among workers in Jiangsu province so as to provide related preventive and control measures.

Methods: A cross-sectional survey was conducted on 238 workers at three butcheries, one trading market and one stockyard. Related risk factors on the different exposures to the disease were also analyzed.

Electrochemical behavior of N-methyl-N'-carboxydecyl-4,4'-bipyridinium probed by surface-enhanced Raman spectroscopy.

Interfacial structure determines the activity and selectivity of a sensor and plays important roles in interfacial electrochemistry, electroanalysis, biosensing, etc. In situ electrochemical Raman spectroscopy appears to be a powerful tool to probe the electrochemical interface and surface process by providing the molecular fingerprint information. Herein, the electrochemical behaviors of N-methyl-N'-carboxydecyl-4,4'-bipyridinium (derivatives of methyl viologens, MV(2+)) with different alkyl chain lengths (n=2 and 10) on roughened Au electrodes were systematically investigated by the electrochemical surface-enhanced Raman spectroscopy (SERS).

Individualized Chemotherapy in Advanced NSCLC Patients Based on mRNA Levels of BRCA1 and RRM1.

Objective: Experimental evidence suggests that the overexpression of breast cancer-specific tumor suppressor protein 1 (BRCA1) gene enhances sensitivity to docetaxel and resistance to cisplatin and ribonucleotide reductase M1 (RRM1) gene overexpression enhances resistance to gemcitabine. To further examine the effect of BRCA1 and RRM1 mRNA levels on outcome in advanced non-small cell lung cancer (NSCLC), we performed this non-randomized phase II clinical trial which tested the hypothesis that customized therapy would confer improved outcome over non-customized therapy.

Methods: RNA was isolated from fresh tumor tissue.

[Detection of KRAS gene mutation and its clinical significance in colorectal adenocarcinoma].

Objective: To explore the clinical significance of KRAS mutation detection in colorectal adenocarcinoma.

Methods: Paraffin-embedded tissue specimens were obtained from 440 patients with colorectal adenocarcinoma. The genomic DNA was extracted.

[Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases].

Objective: To study the clinical manifestations and radiological characteristics, diagnostic methods and outcomes of pulmonary mucosa-associated lymphoid tissue-derived(MALT) lymphoma.

Methods: A retrospective review of clinical, radiological and follow-up data of 29 pulmonary MALT lymphoma cases at Shanghai Pulmonary Hospital affiliated to Tong Ji University from January 2002 to June 2010 was performed.

Results: Among these patients, there were 19(65.

[Focal nodular hyperplasia of liver: a clinicopathologic study of 238 patients].

Objective: To study the clinicopathologic features of focal nodular hyperplasia (FNH) of liver.

Methods: The clinical, radiologic, pathologic findings and follow-up data of 238 cases of FNH were retrospectively analyzed.

Results: The patients included 93 females and 145 males.

[Melanotic epithelioid clear cell tumor of kidney: report of three cases].

Objective: To study the pathologic features and immunophenotype of 3 cases of melanotic epithelioid clear cell tumor of kidney.

Methods: More than 2000 cases of renal tumors were retrospectively reviewed. Three cases of melanotic epithelioid clear cell tumor were identified.

Clinical and pathological studies of borderline gastrointestinal stromal tumors.

Background: Borderline gastrointestinal stromal tumors (GISTs) are intermediate tumors between benign and malignant variants; however, the clinical and pathological features of borderline GISTs remain poorly defined. This study aimed to characterize GISTs and to identify a set of borderline criteria for practical use.

Methods: Medical records and specimens of 840 patients from 12 hospitals were retrospectively examined.

[Clinicopathologic analysis of pulmonary lymphangioleiomyomatosis].

Objective: To improve the understanding and diagnosis of pulmonary lymphangioleiomyomatosis (LAM).

Methods: Fifteen cases of LAM of our hospital were presented and 73 cases reported in domestic literature from 1993 to 2008 were reviewed. By means of histological and immunohistochemical(IHC)studies, the clinical and pathological features of LAM were analyzed.

Clinical and histopathological alterations of lymphangioleiomyomatosis in 14 Chinese patients.

Background: Lymphangioleiomyomatosis (LAM) is a rare disease that predominantly affects young females. It is considered as an "orphan" life-threatening disease of unknown etiology, with uncertain clinical prognosis, and no effective treatment. LAM can arise sporadically or in association with tuberous sclerosis complex (TSC), an autosomal inherited syndrome characterized by hamartoma-like tumor growth and pathologic features that are distinct from manifestations of pulmonary LAM.

[Gefitinib in the treatment of refractory non-small cell lung cancer].

Objective: To observe the efficacy, median survival time, time to progression, quality of life and adverse effect of gefitinib (IRESSA) in the treatment for refractory advanced non-small cell lung cancer (NSCLC).

Methods: Forty-one patients with stage III b to IV NSCLC who had previously treated with 2-7 cycles of platinum-based chemotherapy were enrolled into the study, 85.4% of the patients had received second line chemotherapy.

[Activity of toremifene plus mitomycin, vindesin and cisplatin regimen in unresectable non-small cell lung cancer].

Objective: To investigate the activity and clinical efficacy of toremifene plus mitomycin, vindesin and cisplatin regimen (MVP) in non-small cell lung cancer (NSCLC).

Methods: A549 cells were seeded into 96 wells at the concentration of 10 x 10(4)cells/well and exposed to different agents. Seventy-two hours later, the cytotoxicity of the agents were evaluated with the method of MTT.

C-kit gene mutation in human gastrointestinal stromal tumors.

Aim: To investigate the significance of c-kit gene mutation in gastrointestinal stromal tumors (GIST).

Methods: Fifty two cases of GIST and 28 cases of other tumors were examined. DNA samples were extracted from paraffin sections and fresh blocks.