Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection.

Background: Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines and antiviral drugs are limited by viral variation and drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza virus infection.

Methods: In this study, we designed and fabricated covalent organic framework (COF) based theranostic platforms (T705@DATA-COF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nano-carrier and Cy3-labeled single DNA (ssDNA) probe.

Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration.

Aim: To evaluate the efficacy of Goji berry supplementation on improving macular pigment, serum zeaxanthin levels and visual acuity in patients with early age-related macular degeneration (AMD).

Methods: A total of 114 patients (aged from 51 to 92y, mean age 69.53±8.

A simple synthetic route to polyoxovanadate-based organic-inorganic hybrids using EEDQ as an ester coupling agent.

A reaction strategy for the post-functionalization of hexavanadate derivatives is presented herein. In this study, five polyoxovanadate-based organic-inorganic hybrids TBA[VO{(OCH)CCOO(CH)CH}] (2), TBA[VO{(OCH)CCOO(CH)CH[double bond, length as m-dash]CH}] (3), TBA[VO{(OCH)CCOOCHCF}] (4), TBA[VO{(OCH)CCOO(CHCHO)CH}] (5), and TBA[VO{(OCH)CCOO(CH)OH}]·2CHCHOH (6) were successfully synthesized via esterification of carboxylic acid groups-containing TBA[VO{(OCH)CCOOH}] (1) with five alcohols possessing different functional groups. These hybrids were characterized by single crystal X-ray diffraction, IR, ESI-MS, H and C-NMR spectroscopies, and elemental analysis.