Retinal neovascularization induced by mutant gene inhibited in an inherited retinitis pigmentosa mouse model: an study.

Aim: To explore whether the retinal neovascularization (NV) in a genetic mutant mice model could be ameliorated in an inherited retinitis pigmentosa (RP) mouse, which would help to elucidate the possible mechanism and prevention of retinal NV diseases in clinic.

Methods: The mice, the genetic mutant mouse model of retinal NV caused by the homozygous mutation of gene, with the mice, the inherited RP mouse caused by homozygous mutation of gene were bred. Intercrossing of the above two mice led to the birth of the F1 hybrids, further inbreeding of which gave birth to the F2 offspring.