Publications by authors named "Jian-Ching Liau"

Background: The incidence of autoimmune diseases is increasing in developed countries, possibly due to the modern Western diet and lifestyle. We showed earlier that polysaccharides derived from the medicinal fungus Hirsutella sinensis produced anti-inflammatory, anti-diabetic and anti-obesity effects by modulating the gut microbiota and increasing the abundance of the commensal Parabacteroides goldsteinii in mice fed with a high-fat diet.

Methods: We examined the effects of the prebiotics, H.

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Article Synopsis
  • A water extract from a medicinal fungus extends the lifespan of nematodes and potentially influences longevity through its effects on certain proteins.
  • The extract reduces levels of fibrillarin, which is linked to shorter lifespans, while increasing the expression of the autophagosomal protein marker LGG-1.
  • Low molecular weight compounds from the extract enhance lifespan in nematodes and promote autophagy in human cells, indicating that autophagy and stress resistance play key roles in lifespan extension.
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The caterpillar fungus Ophiocordyceps sinensis is a medicinal mushroom increasingly used as a dietary supplement for various health conditions, including fatigue, chronic inflammation, and male impotence. Here, we propose strategies to address the existing challenges related to the study and commercial production of this mysterious fungus.

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Ethnopharmacological Relevance: The medicinal mushroom Antrodia cinnamomea possesses anticancer properties but the active compounds responsible for these effects are mostly unknown.

Aim Of The Study: We aimed to identify novel A. cinnamomea compounds that produce cytotoxic effects on cancer cells.

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The caterpillar fungus Ophiocordyceps sinensis (previously called Cordyceps sinensis) has been used for centuries in Asia as a tonic to improve health and longevity. Recent studies show that O. sinensis produces a wide range of biological effects on cells, laboratory animals and humans, including anti-fatigue, anti-infection, anti-inflammatory, antioxidant, and anti-tumor activities.

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