Publications by authors named "Jian-Bo Tian"
Article Synopsis
- Dysregulation of enhancer transcription and the role of enhancer RNAs (eRNAs) in cancer is explored, aiming to identify genetic factors influencing eRNA expression to better understand cancer mechanisms.! -
- Researchers conducted a detailed analysis of eRNA quantitative trait loci (eRNAQTLs) in colorectal cancer samples from China, integrating epigenomic and genetic data from over 154 CRC cases to establish the first eRNAQTL profiles.! -
- A total of 300,112 eRNAQTLs were identified across various cancers, highlighting their connection to cancer risk and potential therapeutic targets, with a specific focus on an eRNAQTL variant (rs3094296-T) that reduces colorectal cancer risk in Chinese
Background: The recent discovery of emerging relapsing fever group Borrelia (RFGB) species, such as Borrelia miyamotoi, poses a growing threat to public health. However, the global distribution and associated risk burden of these species remain uncertain. We aimed to map the diversity, distribution, and potential infection risk of RFGB.
View Article and Find Full Text PDFObjectives: Selenium deficiency can be associated with increased susceptibility to some viral infections and even more severe diseases. In this study, we aimed to examine whether this association applies to severe fever with thrombocytopenia syndrome (SFTS).
Method: An observational study was conducted based on the data of 13,305 human SFTS cases reported in mainland China from 2010 to 2020.
Introduction: Maintenance hemodialysis (MHD) patients are highly threatened in the novel coronavirus disease 2019 (COVID-19) pandemic, but evidence of risk factors for mortality in this population is still lacking.
Methods: We followed outcomes of the overall MHD population of Wuhan, including 7154 MHD patients from 65 hemodialysis centers, from January 1 to May 4, 2020. Among them, 130 were diagnosed with COVID-19.
Rationale & Objective: Patients receiving maintenance hemodialysis (MHD) are highly vulnerable to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The current study was designed to evaluate the prevalence of SARS-CoV-2 infection based on both nucleic acid testing (NAT) and antibody testing in Chinese patients receiving MHD.
Study Design: Cross-sectional study.
Background: Reports indicate that those most vulnerable to developing severe coronavirus disease 2019 (COVID-19) are older adults and those with underlying illnesses, such as diabetes mellitus, hypertension, or cardiovascular disease, which are common comorbidities among patients undergoing maintenance hemodialysis. However, there is limited information about the clinical characteristics of hemodialysis patients with COVID-19 or about interventions to control COVID-19 in hemodialysis centers.
Methods: We collected data retrospectively through an online registration system that includes all patients receiving maintenance hemodialysis at 65 centers in Wuhan, China.