Publications by authors named "Jian-Bin Huang"

Two new species of starry longhorn beetles are described from China, i.e. Anoplophora iadina sp.

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  • - X-linked hypophosphatemic rickets (XLH) is caused by mutations in the PHEX gene, leading to elevated levels of fibroblast growth factor 23 (FGF23) and impaired phosphate absorption, resulting in rickets and poor bone mineralization.
  • - Two specific pathogenic mutations, c.433 G > T (p.Glu145*) and c.2245 T > C (p.Trp749Arg), were identified in XLH patients, with studies showing these mutations reduce PHEX protein levels and intracellular enzyme activity compared to the wild-type PHEX.
  • - PHEX was found to be a direct transcriptional inhibitor of FGF23, with mutant PHEX enhancing F
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Hereditary distal renal tubular acidosis (dRTA) is a rare disease of H excretion defect of α-intercalated cells in renal collecting duct, caused by decreased V-ATPase function due to mutations in the ATP6V1B1 or ATP6V0A4 genes. In the present study, a genetic family with 5 members of the complete dRTA phenotype were found with distal tubule H secretion disorder, hypokalemia, osteoporosis, and kidney stones. A variant NM_020632.

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Parapoynx crisonalis (Walker, 1859) (Lepidoptera: Crambidae) is a major pest of aquatic vegetables and aquatic landscape plants. It has been responsible for causing considerable economic damage to water chestnut (Trapa natans) plants. In the Changsha vicinity of China, P.

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Parapoynx crisonalis is an important pest of many aquatic vegetables including water chestnuts. Understanding the relationship between temperature variations and the population growth rates of P. crisonalis is essential to predicting its population dynamics in water chestnuts ponds.

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Background: Aseptic loosening is a significant impediment to joint implant longevity. Prosthetic wear particles are postulated to play a central role in the onset and progression of periprosthetic osteolysis, leading to aseptic loosening of the prosthesis.

Methods: We investigated the inhibitory effects of a lentivirus-mediated short hairpin RNA that targets the TNF-alpha gene on the particle-induced inflammatory and osteolytic changes via macrophages both in vitro and in vivo.

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Colorectal cancer is one of the most common malignancies. Previous studies have reported that cortactin (CTTN) is often overexpressed in tumors and is associated with metastasis and poor prognosis of patients. The abnormal expression of microRNAs (miRNAs or miRs) is closely related to the development and progression of various types of cancer, including colorectal cancer.

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In this work, we report self-assembled metallogels formed from a ligand of trimesic amide, N,N',N''-tris(4-pyridyl)trimesic amide (TPTA), induced by Fe(III)/Fe(II) ions. TPTA is difficult to dissolve in water even in the presence of some metal ions such as Cu(2+), Co(2+), Ni(2+), K(+), Na(+) and Mg(2+) under heating, and it exhibits no gelation ability. Interestingly, upon heating TPTA can be dissolved easily in aqueous solution containing Fe(3+)/Fe(2+), and subsequently self-assembled into metallogels after cooling.

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Objective: To study the effect of lipoteichoic acid (LTA) and 5-FU on the expression of caspase-3, EGFR, TGF-α proteins of tumor tissue of H22 cancer bearing mice and its anti-tumor mechanism.

Methods: A total of 40 SPF grade Kunming mice were selected to establish H22 liver cancer model, and then the mice were divided into 4 groups at random with ten mice in each group. Group A was given saline lavage treatment, Group B was treated with 5-FU by intraperitoneal injection, Group C was treated with LTA by lump body injection; Group D was treated with LTA by lump body injection and 5-FU by intraperitoneal injection.

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Objectives: To build GPC3 gene short hairpin interference RNA (shRNA) slow virus vector, observe expression of Huh-7 GPC3 gene in human liver cell line proliferation apoptosis and the effect of GPC3 gene influencing on liver cancer cell growth, and provide theoretical basis for gene therapy of liver cancer.

Methods: Hepatocellular carcinoma cell line Huh-7 was transfected by a RNA interference technique. GPC3 gene expression in a variety of liver cancer cell lines was detected by fluorescence quantitative PCR.

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Cobia (Rachycentron canadum) is an economically important fish species for aquaculture in tropical and sub-tropical areas. Cobia aquaculture industry has severely damaged due to photobacteriosis caused by Photobacterium damselae subsp. piscicida (Pdp), especially in Taiwan.

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Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expression in the murine macrophage cell line, RAW264.

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Joint replacement is the most effective treatment for end-stage osteoarticular disease. However, macrophage-mediated aseptic loosening of joint prosthesis severely hampers the clinical effects of joint replacement. Until now, the mechanism by which macrophages regulate the secretion of inflammatory cytokines after particle stimulation is not clear.

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Aquaporin-1 (AQP1) is a member of aquaporin family that was previously proven to be involved in myocardial dysfunction; however, the role of AQP1 in myocardial stunning is less clear. To determine the change of AQP1 expression level in the heart and its effect on oedema after global myocardial ischemia, 40 adult goats underwent cardiopulmonary bypass (CPB) with an aortic cross-clamp time of 2 h and total bypass time of 6, 12, 24, 48 and 72 h followed by subsequent reperfusion. AQP1 function of eight goats was inhibited by HgCl(2) during the 24 h on CPB.

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The properties and phase diagrams of aqueous mixtures of dodecyltrimethylammonium bromide (C(12)TAB) with the sodium oligoarene sulphonates (POSn), POS2, POS3, POS4, and POS6 have been studied using surface tension and neutron reflectometry to study the surface, and neutron small angle scattering and fluorescence to study the bulk solution. The behavior of POS2 and POS3 is reasonably consistent with mixed micelles of C(12)TAB and POSn-(C(12)TA)(n). These systems exhibit a single critical micelle concentration (CMC) at which the surface tension reaches the usual plateau.

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Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of tumor necrosis factor (TNF)-alpha-targeted small interfering RNA (siRNA) on particle-induced inflammatory cytokine expression in the murine macrophage cell line, RAW264.

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Objective: this study aimed to correlate magnetic resonance (MR) findings and discography with pain response at provocative discography in patients with low back pain.

Methods: ninety-three patients who underwent MR imaging of the lumbar spine and subsequent provocation discography as part of a clinical evaluation of low back pain were enrolled in the study. MR images were then evaluated for disc degeneration, high-intensity zone (HIZ), and endplate abnormalities.

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Article Synopsis
  • This study investigates the relationship between high bilirubin levels and apnea in premature infants weighing more than 1500 g.
  • The findings show that a significant percentage of both premature and term infants with apnea had elevated indirect bilirubin levels, particularly in those under 1500 g and showing apnea symptoms.
  • The research concludes that high bilirubin levels may contribute to apnea in these infants and that treatments aimed at reducing bilirubin can help improve apnea symptoms.
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The 2.6 kb fragment which can complement the Exo(-)Ndv(-)Fix(-) mutants of R. huakuii to Exo(+)Nod(+)Fix(+) was sequenced.

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