The prevalence, diagnostic accuracy and genotype-phenotype correlation of mutations in fibrous dysplasia: a meta-analysis.

Background: There is inconsistent evidence regarding the accuracy of mutations identification for the diagnosis of FD/MAS. This study was performed to estimate the prevalence and diagnostic accuracy of mutations detection and to preliminarily investigate the genotype-phenotype correlation in FD patients.

Methods: Five electronic databases were searched from 1995 to 2024 using search terms related to and fibrous dysplasia.

Mast Cell Infiltration and Subtype Promote Malignant Transformation of Oral Precancer and Progression of Oral Cancer.

Unlabelled: The role of mast cell (MC), a common myeloid-derived immune cell, in the development of oral squamous cell carcinoma (OSCC) is unclear. The aim of this study was to investigate MC infiltration in oral precancer and oral cancer. The evaluation of immune cell infiltration and its association with prognosis in OSCC used RNA sequencing and multiple public datasets.

Effects of long-chained perfluoroalkyl acids (PFAAs) on the uptake and bioaccumulation of short-chained PFAAs in two free-floating macrophytes: Eichhornia crassipes and Ceratophyllum demersum.

Short-chained perfluoroalkyl acids (PFAAs, CF-R, n ≤ 6) have merged as global concerns due to their extensive application and considerable toxicity. However, long-chained PFAAs (n ≥ 7) featured with high persistence are still ubiquitously observed in aquatic environment. To understand the uptake behavior of short-chained PFAAs in aquatic macrophytes, the uptake kinetics, bioconcentration, and translocation of short-chained PFAAs (3 ≤n ≤ 6) in two typical free-floating macrophytes (Eichhornia crassipes and Ceratophyllum demersum) were investigated in the treatments with and without long-chained PFAAs (7 ≤n ≤ 11).

CT-based radiomics analysis of different machine learning models for differentiating gnathic fibrous dysplasia and ossifying fibroma.

Objective: In this study, our aim was to develop and validate the effectiveness of diverse radiomic models for distinguishing between gnathic fibrous dysplasia (FD) and ossifying fibroma (OF) before surgery.

Materials And Methods: We enrolled 220 patients with confirmed FD or OF. We extracted radiomic features from nonenhanced CT images.

Clinicopathological characteristics and diagnostic accuracy of BRAF mutations in ameloblastoma: A Bayesian network analysis.

Objective: This Bayesian network meta-analysis was performed to analyze the associations between clinicopathological characteristics and BRAF mutations in ameloblastoma (AM) patients and to evaluate the diagnostic accuracy.

Materials And Methods: Four electronic databases were searched from 2010 to 2024. The search terms used were specific to BRAF and AM.

Can botulinum toxin injection alleviate the pain of bruxism? A Bayesian network analysis and a single-arm analysis.

Background/purpose: There is inconsistent evidence regarding whether the botulinum toxin A (BTA) injection can relieve pain caused by bruxism. This study aimed to estimate the efficiency of BTA injection in relieving pain caused by bruxism at different follow-up periods.

Materials And Methods: Five electronic databases were searched from 2005 to 2022 using search terms related to botulinum toxin and bruxism.

Confirmation of eosinophilic sialodochitis by terminal duct biopsy.

Objective: To analyse the histopathological features of eosinophilic sialodochitis by using terminal duct biopsy.

Methods: Sixty-five patients with suspected eosinophilic sialodochitis and four with chronic obstructive sialadenitis were prospectively enrolled. Clinical features, laboratory tests and sialograms were comparatively analysed.

[Effects of Governor Vessel electroacupuncture on chloridion homeostasis in the cortex of rats with limb spasm after cerebral ischemia-reperfusion].

Objective: To observe the effect of electroacupuncture (EA) stimulation of Governor Vessel on chloridion (Cl) homeostasis and the expression of γ-aminobutyric acid (GABA) and Na-K-Cl cotransporter 1 (NKCC1) in the cerebral cortex of cerebral ischemia-reperfusion injury (CIRI) model rats, so as to explore its mechanism underl-ying alleviating limb spasm after stroke.

Methods: Forty-five male SD rats were randomly divided into normal, sham-operation, model, EA and baclofen groups, with 9 rats in each group. The CIRI model was established by occlusion of the middle cerebral artery and reperfusion.

Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways.

Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response. In recent years, we have a deep understanding of the neural pathways of itch sensation transmission. However, there are few reports on the role of non-neuronal cells in itch.

[Application of Deep Learning in Differential Diagnosis of Ameloblastoma and Odontogenic Keratocyst Based on Panoramic Radiographs].

Objective To evaluate the accuracy of different convolutional neural networks (CNN),representative deep learning models,in the differential diagnosis of ameloblastoma and odontogenic keratocyst,and subsequently compare the diagnosis results between models and oral radiologists. Methods A total of 1000 digital panoramic radiographs were retrospectively collected from the patients with ameloblastoma (500 radiographs) or odontogenic keratocyst (500 radiographs) in the Department of Oral and Maxillofacial Radiology,Peking University School of Stomatology.Eight CNN including ResNet (18,50,101),VGG (16,19),and EfficientNet (b1,b3,b5) were selected to distinguish ameloblastoma from odontogenic keratocyst.

Bibliometric analysis of immunotherapy for head and neck squamous cell carcinoma.

Background/purpose: Head and neck squamous cell carcinoma (HNSCC) is a serious disease endangering the health of patients, and the application of immunotherapy in HNSCC is gradually emerging. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots of immunotherapy for HNSCC.

Perfluoroalkyl acids in the aquatic environment of a fluorine industry-impacted region: Spatiotemporal distribution, partition behavior, source, and risk assessment.

The present study investigated the temporal and spatial distributions, partition behaviors, sources, and risks of 14 perfluoroalkyl acids (PFAAs) in the aquatic environment of a fluorine industry-impacted region. The total concentrations of 14 PFAAs (ΣPFAAs) were 118.10-2235.

[Chemical pattern recognition of Atractylodes chinensis from different producing areas and establishment of quantitative analysis of multi-components by single marker (QAMS) method for four components].

This study established the fingerprint and combined it with chemical pattern recognition to evaluate the quality of Atractylodes chinensis samples from different producing areas and then employed the quantitative analysis of multi-components by single marker(QAMS) method to verify the feasibility and applicability of the established method in the quality evaluation of A. chinensis. The fingerprints of A.

[Clinical observation on wrist-ankle acupuncture for shoulder-hand syndrome phaseⅠafter stroke].

Objective: To compare the clinical efficacy between wrist-ankle acupuncture and conventional acupuncture on shoulder-hand syndrome (SHS) phaseⅠafter stroke.

Methods: A total of 64 patients with SHS phaseⅠafter stroke were randomized into a wrist-ankle acupuncture group and a conventional acupuncture group, 32 cases in each group. On the basis treatment of internal medicine and conventional rehabilitation, wrist-ankle acupuncture was applied at upper 4 area, upper 5 area and upper 6 area on the affected side in the wrist-ankle acupuncture group, while acupuncture was applied at Jianyu (LI 15), Quchi (LI 11), Shousanli (LI 10), etc.

Orthokeratinized odontogenic cysts: A clinicopathologic study of 159 cases and molecular evidence for the absence of PTCH1 mutations.

Background: Orthokeratinized odontogenic cyst (OOC), a newly designated entity of odontogenic cysts, is an intraosseous jaw cyst that is entirely or predominantly lined by orthokeratinized squamous epithelium. The aim of this study was to report a large series of OOC to substantiate its clinicopathologic profiles and to investigate PTCH1 mutations in OOCs.

Method: The clinicopathologic features of 167 OOCs from 159 patients were analyzed and the immunohistochemical expression of markers related to cell differentiation and proliferation was evaluated.

A three-in-one alveolar process reconstruction protocol for maxillary molar sites with severe residual bone height deficiency: A proof-of-concept pilot study.

Background: Implant placement in maxillary molar sites with severe height deficiency often requires multiple surgeries, which was time-consuming, invasive, and subject to serious postoperative complications.

Purpose: To introduce and assess a three-in-one technique (extraction, alveolar ridge preservation [ARP], and sinus elevation) for augmenting deficiency maxillary molar alveolar ridges.

Material And Methods: Fourteen patients with severe posterior maxillary ridge height deficiency underwent extraction, sinus elevation via an intrasocket window and ARP using sticky bone and then covered with acellular dermal matrix (ADM).

Removal of perfluoroalkyl acids and dynamic succession of biofilm microbial communities in the decomposition process of emergent macrophytes in wetlands.

Perfluoroalkyl acids (PFAAs) are emerging contaminants that pose significant environmental and health concerns. Water-sediment-macrophyte residue systems were established to clarify the removal efficiency of PFAAs, explore possible removal pathways, and profile the dynamic succession of biofilm microbial communities in the decomposition process. These systems were fortified with 12 PFAAs at three concentration levels.

Interactions between dissolved organic matter and perfluoroalkyl acids in natural rivers and lakes: A case study of the northwest of Taihu Lake Basin, China.

Understanding the interactions between dissolved organic matter (DOM) and perfluoroalkyl acids (PFAAs) is essential for predicting the distribution, transport, and fate of PFAAs in aquatic environments. Based on field investigations in the northwest of Taihu Lake Basin combined with laboratory experiments, we obtained DOM and PFAA concentrations as well as compositions and investigated key factors of DOM affecting PFAA variability and capture of PFAAs by DOM. Results indicated that the total concentrations of PFAAs were 73.

Emerging Role of High Glucose Levels in Cancer Progression and Therapy.

Extensive research has indicated that high glucose levels play an important role in cancer. A high glycaemic index, glycaemic load diet, high sugar intake, high blood glucose and diabetes mellitus all increase the risk of cancer. Various signals are involved in high glucose-induced tumorigenesis, cancer proliferation, apoptosis, invasion and multidrug resistance.

Ecotoxicological responses and removal of submerged macrophyte Hydrilla verticillate to multiple perfluoroalkyl acid (PFAA) pollutants in aquatic environments.

The ubiquitous existence of perfluoroalkyl acids (PFAAs) in aquatic environments might pose toxic potential to ecosystems. To assess the ecotoxicological responses and removal of submerged macrophyte to multiple PFAA pollutants in aquatic environments, a typical submerged macrophyte, Hydrilla verticillate, was exposed to solutions with 12 typical PFAAs in the present study. The results showed that PFAAs at concentrations higher than 10 μg/L had significantly passive effects on biomass, relative growth rates, chlorophyll contents, and chlorophyll autofluorescence.