Establishment and maturation of gut microbiota in White King pigeon squabs: role of pigeon milk.

Background: Pigeons are significant economic animals in China; however, research regarding the establishment and influencing factors of gut microbiota in squabs remains limited. Understanding how the gut microbiota develops in pigeons, particularly in relation to pigeon milk, is importance in pigeon production. This study aims to elucidate the establishment characteristics of the gut microbiota in White King pigeon squabs and explore the role of pigeon milk in this process.

Histone modification-based functional characterization and genetic association of polymorphisms in LRRC6 and MTMR10 within CRC susceptibility regions 8q24 and 15q13.3.

Background: Genome-wide association studies (GWAS) have identified susceptibility loci for colorectal cancer (CRC), but the underlying mechanisms remain unclear. This study investigates functional genetic variants in promoter regions of Leucine Rich Repeat Containing 6 (LRRC6) at 8q24 and Myotubularin Related Protein 10 (MTMR10) at 15q13.3 and their association with CRC susceptibility.

Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT.

Purpose: Retinopathy of prematurity (ROP) stage is defined by the visual appearance of the vascular-avascular border, which reflects a spectrum of pathologic neurovascular tissue (NVT). Previous work demonstrated that the thickness of the ridge lesion, measured using OCT, corresponds to higher clinical diagnosis of stage. This study evaluates whether the volume of anomalous NVT (ANVTV), defined as abnormal tissue protruding from the regular contour of the retina, can be measured automatically using deep learning to develop quantitative OCT-based biomarkers in ROP.

Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum.

Feed efficiency (FE) is a crucial trait in pig production that influences both economic viability and environmental sustainability. The jejunum, an essential organ for nutrient absorption, plays a significant role in determining FE by affecting how pigs process and utilize feed. To explore the genetic and regulatory mechanisms behind FE, we conducted an integrative multi-omics study using RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) on pigs with high and low FE.

A special two-working-electrode system: a summary of recent development in fabrication and application of interdigitated array electrodes.

The utilization of dual-working-electrode mode of interdigitated array (IDA) electrodes and other two-electrode systems has revolutionized electrochemical detection by enabling the simultaneous and independent detection of two species, accompanied by the exhibition of unique characteristics. In contrast to conventional dual-potential electrodes, such as the rotating ring disk electrodes (RRDE), IDA electrodes demonstrate analogous yet vastly improved performance, characterized by remarkable collection efficiency and sensitivity. Notably, due to the distinctive microscale structure of IDA electrode, the special "feedback" effect makes IDA a unique signal amplifier.

Gingival Soft Tissue Integrative Zirconia Abutments with High Fracture Toughness and Low-Temperature Degradation Resistance.

Low fracture toughness, low-temperature degradation (LTD) susceptibility, and inadequate soft tissue integration greatly limit the application of zirconia ceramic abutment. Integrating the "surface" of hard all-ceramic materials into the gingival soft tissue and simultaneously promoting the "inner" LTD resistance and fracture toughness is challenging. Composite ceramics are effective in improving the comprehensive properties of materials.

Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation.

Objective: This study is to develop and validate a robust risk prediction model for mild cognitive impairment (MCI) in patients with malignant haematological diseases after haematopoietic stem cell transplantation (HSCT).

Methods: In this study, we analysed the clinical data of the included patients. Logistic regression analysis was used to identify independent risk factors for cognitive impairment after HSCT in patients with malignant haematological diseases, and a risk prediction model was constructed.

A Chromosomal-level genome assembly and annotation of fat greenling (Hexagrammos otakii).

Fat greenling (Hexagrammos otakii Jordan & Starks, 1895) is a valuable marine fish species, crucial for aquaculture in Northern China due to its high-quality meat and significant economic value. However, the aquaculture industry faces challenges such as trait degradation, early sexual maturity, and disease susceptibility, necessitating advanced genomic interventions for sustainable cultivation. This study presents the first chromosomal-level genome assembly of H.

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.

Itaconate is a metabolite catalyzed by cis-aconitate decarboxylase (ACOD1), which is mainly produced by activated macrophages and secreted into the extracellular environment to exert complex bioactivity. In the tumor microenvironment, itaconate is concentrated and induces an immunosuppressive response. However, whether itaconate can be taken up by tumor cells and its mechanism of action remain largely unclear.

Enhancing sand screen performance with integrated slurry testing and CFD-DEM modelling.

Understanding the behavior of sand screens is crucial for optimizing sand control strategies and preventing wellbore failure, which can significantly impact reservoir management and production efficiency. This paper presents a comprehensive experimental and numerical modeling study on sand screen performance, aimed at providing insights prior to real-field applications. The study evaluated a 200-μm wire-wrapped screen (WWS) using slurry tests to determine the amount of sand retained, sand produced and retained permeability to assess screen efficiency.

CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a globally severe cancer with an unfavorable prognosis. PANoptosis, a form of cell death regulated by PANoptosomes, plays a role in numerous cancer types. However, the specific roles of genes associated with PANoptosis in the development and advancement of ccRCC remain unclear.

Long-Lasting and High-Power-Density Yarn-Based Moisture-Enabled Electric Generator for Self-powered Electronic Textiles.

1D moisture-enabled electric generators (MEGs) hold great promise for powering electronic textiles, but their current limitations in power output and operational duration restrict their application in wearable technology. This study introduces a high-performance yarn-based moisture-enabled electric generator (YMEG), which comprises a carbon-fiber core, a cotton yarn active layer with a radial gradient of poly(4-styrensulfonic acid) and poly(vinyl alcohol) (PSSA/PVA), and an aluminum wire as the outer electrode. The unique design maintains a persistent moisture gradient between the interior and exterior electrodes, enhancing performance through the continuous proton diffusion from PSSA and Al⁺ ions from the aluminum wire.

Student-Led Medical Mandarin Summer Course for Medical Students With Existing Mandarin Fluency.

Introduction: In regions with significant Mandarin-speaking populations, language discordance in health care poses considerable challenges. Previous studies have shown that patients with language-concordant providers had higher ratings of satisfaction and trust. Despite this, there is a shortage of Mandarin-speaking primary care physicians in California.

Nerve Fiber Layer Schisis in Coats Disease.

Purpose: To describe two cases of pediatric patients with Coats disease who developed nerve fiber layer (NFL) schisis.

Methods: Observational case series.

Results: Two male pediatric patients, ages 2 and 14, who were being treated for Coats disease were found to have NFL schisis on optical coherence tomography.

Case report: Outflow reconstruction with pre-frozen allograft blood vessels during partial hepatectomy followed by tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis.

surgery and autotransplantation may provide a promising option for radical resection of conventionally unresectable liver tumors. Two cirrhotic patients with hepatocellular carcinoma (HCC), which has an "awkward seat" located in the "intrahepatic vascular triangle area (IVTA)" that consists of the middle hepatic vein (MHV), the right branches of the Glisson sheath, and the inferior vena cava (IVC), underwent extended right-half hepatectomy followed by tumor resection and partial liver autotransplantation. Innovatively, the outflow of the tumor-free liver was reconstructed using pre-frozen allograft blood vessels from brain-dead donors; the patients recovered well postoperation.

Preservative effects and mechanism of condensed tannins from Cercis chinensis Bunge leaves on fresh-cut lotus root.

This study aimed to investigate the potential of condensed tannins isolated from Cercis chinensis Bunge leaves as natural preservatives for fruits and vegetables. The research demonstrated that C. chinensis leaves condensed tannins (CLCT) significantly delay the browning process and reduce nutritional loss in fresh-cut lotus roots.

Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity.

Importance: Capturing high-quality images of the entire peripheral retina while minimizing the use of scleral depression could increase the quality of examinations for retinopathy of prematurity (ROP) while reducing neonatal stress.

Objective: To evaluate whether an investigational handheld ultra-widefield optical coherence tomography (UWF-OCT) device without scleral depression can be used to document high-quality images of the peripheral retina for use in ROP examinations.

Design, Setting, And Participants: This was a prospective, cross-sectional study in the neonatal intensive care unit at a single academic medical center.

Highly Compressible Micro/Nanofibrous Sponges with Thin-Walled Cavity Structures Enable Low-Frequency Noise Reduction.

Increasing noise pollution has generated a tremendous threat to human health and incurred great economic losses. However, most existing noise-absorbing materials present a significant challenge in achieving lightweight, robust mechanical stability, and efficient low-frequency (<1000 Hz) noise reduction. Herein, we create highly compressible micro/nanofibrous sponges with thin-walled cavity structures for efficient noise reduction through electrospinning and dispersion casting.

Risk Prediction Model for Isoniazid Dosing in Tuberculosis Meningitis Patients in Southwest China.

Purpose: Tuberculosis meningitis (TBM) has emerged as the most lethal type of disease. The prognosis of meningitis is often related to disease severity and early therapeutic intervention.

Methods: Patients were screened for primary TBM and received a quadruple regimen comprising isoniazid (standard dose of 300 mg/day and high dose of 600 mg/day), rifampin, ethambutol, and pyrazinamide.

28-Day Repeated Dose Toxicity and Toxicokinetics Study on Dihydroartemisinin (DHA) in SD Rats.

Dihydroartemisinin (DHA) is an effective antimalarial drug with potential antitumor efficacy, yet toxicological information is limited. The present study was designed to evaluate the potential toxicity of oral DHA. DHA was administered orally by gavage to SD rats at doses of 0, 25, 50, and 75/60 mg/kg b.

Electrochemical Oxidative Cascade Cyclization of Alkenyl Alcohols with External Nucleophiles to Access Amino- and Hydroxy-Functionalized -Heterocycles.

A convenient electrochemical oxidative cascade cyclization of alkenes equipped with pendant alcohols with general nucleophiles was developed. Using readily available diarylmethanimine and carboxylic acids as nucleophilic sources, a broad range of internal alkene and terminal alkene substrates could produce RCO- and ArCN-functionalized -heterocycles in moderate to high yields without the requirement for external oxidants and metals. These resulting products can subsequently be hydrolyzed to yield valuable NH- and OH-functionalized tetrahydrofurans and tetrahydropyranes under mild conditions.

STING exerts antiviral innate immune response by activating pentose phosphate pathway.

Background: The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator of interferon genes (STING) is a key component of this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored.

Methods: Metabolomics analysis was used for detecting metabolic alterations in spleens from STING knockout (KO) and wild-type (WT) mice.

IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis.

Indoleamine 2,3-dioxygenase 1 (IDO1) plays an anti-inflammatory role in autoimmune disease. However, its specific function in ankylosing spondylitis (AS) remain unclear. This study aimed to investigate the potential role of IDO1 in AS.

PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib.

As a chromatin remodelling factor, high mobility group A1 (HMGA1) plays various roles in both physiological and pathological conditions. However, its role in DNA damage response and DNA damage-based chemotherapy remains largely unexplored. In this study, we report the poly ADP-ribosylation (PARylation) of HMGA1 during DNA damage, leading to desensitization of esophageal squamous cell carcinoma (ESCC) cells to the poly(ADP-ribose) polymerase 1 (PARP1) inhibitor, olaparib.

Estimation of Sow Backfat Thickness Based on Machine Vision.

Controlling the backfat thickness of sows within an appropriate range during different production stages helps to increase the number of pigs weaned per sow per year and ultimately enhances the economic benefit to the pig farm. To obtain the backfat thickness of sows automatically, a backfat thickness estimation method based on machine vision is proposed. First, the backfat thickness values and 3D images of the buttocks of 154 Landrace-Yorkshire crossbred sows were obtained using a veterinary ultrasound backfat meter and Azure Kinect DK camera.