A Chromosomal-level genome assembly and annotation of fat greenling (Hexagrammos otakii).

Fat greenling (Hexagrammos otakii Jordan & Starks, 1895) is a valuable marine fish species, crucial for aquaculture in Northern China due to its high-quality meat and significant economic value. However, the aquaculture industry faces challenges such as trait degradation, early sexual maturity, and disease susceptibility, necessitating advanced genomic interventions for sustainable cultivation. This study presents the first chromosomal-level genome assembly of H.

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.

Itaconate is a metabolite catalyzed by cis-aconitate decarboxylase (ACOD1), which is mainly produced by activated macrophages and secreted into the extracellular environment to exert complex bioactivity. In the tumor microenvironment, itaconate is concentrated and induces an immunosuppressive response. However, whether itaconate can be taken up by tumor cells and its mechanism of action remain largely unclear.

Enhancing sand screen performance with integrated slurry testing and CFD-DEM modelling.

Understanding the behavior of sand screens is crucial for optimizing sand control strategies and preventing wellbore failure, which can significantly impact reservoir management and production efficiency. This paper presents a comprehensive experimental and numerical modeling study on sand screen performance, aimed at providing insights prior to real-field applications. The study evaluated a 200-μm wire-wrapped screen (WWS) using slurry tests to determine the amount of sand retained, sand produced and retained permeability to assess screen efficiency.

CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a globally severe cancer with an unfavorable prognosis. PANoptosis, a form of cell death regulated by PANoptosomes, plays a role in numerous cancer types. However, the specific roles of genes associated with PANoptosis in the development and advancement of ccRCC remain unclear.

Long-Lasting and High-Power-Density Yarn-Based Moisture-Enabled Electric Generator for Self-powered Electronic Textiles.

1D moisture-enabled electric generators (MEGs) hold great promise for powering electronic textiles, but their current limitations in power output and operational duration restrict their application in wearable technology. This study introduces a high-performance yarn-based moisture-enabled electric generator (YMEG), which comprises a carbon-fiber core, a cotton yarn active layer with a radial gradient of poly(4-styrensulfonic acid) and poly(vinyl alcohol) (PSSA/PVA), and an aluminum wire as the outer electrode. The unique design maintains a persistent moisture gradient between the interior and exterior electrodes, enhancing performance through the continuous proton diffusion from PSSA and Al⁺ ions from the aluminum wire.

Student-Led Medical Mandarin Summer Course for Medical Students With Existing Mandarin Fluency.

Introduction: In regions with significant Mandarin-speaking populations, language discordance in health care poses considerable challenges. Previous studies have shown that patients with language-concordant providers had higher ratings of satisfaction and trust. Despite this, there is a shortage of Mandarin-speaking primary care physicians in California.

Nerve Fiber Layer Schisis in Coats Disease.

Purpose: To describe two cases of pediatric patients with Coats disease who developed nerve fiber layer (NFL) schisis.

Methods: Observational case series.

Results: Two male pediatric patients, ages 2 and 14, who were being treated for Coats disease were found to have NFL schisis on optical coherence tomography.

Case report: Outflow reconstruction with pre-frozen allograft blood vessels during partial hepatectomy followed by tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis.

surgery and autotransplantation may provide a promising option for radical resection of conventionally unresectable liver tumors. Two cirrhotic patients with hepatocellular carcinoma (HCC), which has an "awkward seat" located in the "intrahepatic vascular triangle area (IVTA)" that consists of the middle hepatic vein (MHV), the right branches of the Glisson sheath, and the inferior vena cava (IVC), underwent extended right-half hepatectomy followed by tumor resection and partial liver autotransplantation. Innovatively, the outflow of the tumor-free liver was reconstructed using pre-frozen allograft blood vessels from brain-dead donors; the patients recovered well postoperation.

Preservative effects and mechanism of condensed tannins from Cercis chinensis Bunge leaves on fresh-cut lotus root.

This study aimed to investigate the potential of condensed tannins isolated from Cercis chinensis Bunge leaves as natural preservatives for fruits and vegetables. The research demonstrated that C. chinensis leaves condensed tannins (CLCT) significantly delay the browning process and reduce nutritional loss in fresh-cut lotus roots.

Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity.

Importance: Capturing high-quality images of the entire peripheral retina while minimizing the use of scleral depression could increase the quality of examinations for retinopathy of prematurity (ROP) while reducing neonatal stress.

Objective: To evaluate whether an investigational handheld ultra-widefield optical coherence tomography (UWF-OCT) device without scleral depression can be used to document high-quality images of the peripheral retina for use in ROP examinations.

Design, Setting, And Participants: This was a prospective, cross-sectional study in the neonatal intensive care unit at a single academic medical center.

Highly Compressible Micro/Nanofibrous Sponges with Thin-Walled Cavity Structures Enable Low-Frequency Noise Reduction.

Increasing noise pollution has generated a tremendous threat to human health and incurred great economic losses. However, most existing noise-absorbing materials present a significant challenge in achieving lightweight, robust mechanical stability, and efficient low-frequency (<1000 Hz) noise reduction. Herein, we create highly compressible micro/nanofibrous sponges with thin-walled cavity structures for efficient noise reduction through electrospinning and dispersion casting.

Risk Prediction Model for Isoniazid Dosing in Tuberculosis Meningitis Patients in Southwest China.

Purpose: Tuberculosis meningitis (TBM) has emerged as the most lethal type of disease. The prognosis of meningitis is often related to disease severity and early therapeutic intervention.

Methods: Patients were screened for primary TBM and received a quadruple regimen comprising isoniazid (standard dose of 300 mg/day and high dose of 600 mg/day), rifampin, ethambutol, and pyrazinamide.

28-Day Repeated Dose Toxicity and Toxicokinetics Study on Dihydroartemisinin (DHA) in SD Rats.

Dihydroartemisinin (DHA) is an effective antimalarial drug with potential antitumor efficacy, yet toxicological information is limited. The present study was designed to evaluate the potential toxicity of oral DHA. DHA was administered orally by gavage to SD rats at doses of 0, 25, 50, and 75/60 mg/kg b.

Electrochemical Oxidative Cascade Cyclization of Alkenyl Alcohols with External Nucleophiles to Access Amino- and Hydroxy-Functionalized -Heterocycles.

A convenient electrochemical oxidative cascade cyclization of alkenes equipped with pendant alcohols with general nucleophiles was developed. Using readily available diarylmethanimine and carboxylic acids as nucleophilic sources, a broad range of internal alkene and terminal alkene substrates could produce RCO- and ArCN-functionalized -heterocycles in moderate to high yields without the requirement for external oxidants and metals. These resulting products can subsequently be hydrolyzed to yield valuable NH- and OH-functionalized tetrahydrofurans and tetrahydropyranes under mild conditions.

STING exerts antiviral innate immune response by activating pentose phosphate pathway.

Background: The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator of interferon genes (STING) is a key component of this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored.

Methods: Metabolomics analysis was used for detecting metabolic alterations in spleens from STING knockout (KO) and wild-type (WT) mice.

IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis.

Indoleamine 2,3-dioxygenase 1 (IDO1) plays an anti-inflammatory role in autoimmune disease. However, its specific function in ankylosing spondylitis (AS) remain unclear. This study aimed to investigate the potential role of IDO1 in AS.

PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib.

As a chromatin remodelling factor, high mobility group A1 (HMGA1) plays various roles in both physiological and pathological conditions. However, its role in DNA damage response and DNA damage-based chemotherapy remains largely unexplored. In this study, we report the poly ADP-ribosylation (PARylation) of HMGA1 during DNA damage, leading to desensitization of esophageal squamous cell carcinoma (ESCC) cells to the poly(ADP-ribose) polymerase 1 (PARP1) inhibitor, olaparib.

Estimation of Sow Backfat Thickness Based on Machine Vision.

Controlling the backfat thickness of sows within an appropriate range during different production stages helps to increase the number of pigs weaned per sow per year and ultimately enhances the economic benefit to the pig farm. To obtain the backfat thickness of sows automatically, a backfat thickness estimation method based on machine vision is proposed. First, the backfat thickness values and 3D images of the buttocks of 154 Landrace-Yorkshire crossbred sows were obtained using a veterinary ultrasound backfat meter and Azure Kinect DK camera.

Cordycepin improves liver fibrosis and the intestinal flora disturbance induced by 3,5-diethoxycarbonyl-1,4-dihydroxylidine in mice.

Background And Aims: Studies have shown that improving the intestinal flora can alleviate the progression of liver fibrosis. Cordycepin has shown potential anti-inflammatory and anti-fibrosis effects. In this study, we aimed to investigate the effects of cordycepin on liver fibrosis and how it affects the intestinal flora composition to determine a potentially effective therapeutic approach for liver fibrosis.

Structural evolution and nanodomain formation in blend films of a block copolymer and homopolymer.

This study explores the concurrent formation of surface perforations, parallel cylinders, and double gyroids in symmetric PS--PMMA/hPS blend films during isothermal annealing at 205 and 240 °C. By controlling the weight fraction ratio of PS--PMMA to hPS at 75/25, we systematically examined the impact of film thickness and annealing temperature on nanodomain development. Using GISAXS and SEM, we observed that thin films rapidly formed surface perforations and underlying parallel cylinders at both annealing temperatures.

Evaluation and spatiotemporal evolution of veterinary talent competitiveness: a new perspective of veterinary education.

Introduction: Improving the quantity and quality of veterinary talent cultivation is an urgent issue to address in current veterinary education and is key to enhancing veterinary talent competitiveness. Starting from an industrial perspective, the introduction of scientific analytical methods for studying veterinary talent competitiveness offers a new view on veterinary education and helps to improve the quality of veterinary education and talent cultivation.

Methods: This study develops a veterinary talent competitiveness evaluation index based on the characteristics of veterinary talent.

Electromagnetic-Driven Spider-Inspired Soft Robot Using Electroelastic Materials and Conductive Actuators.

Soft robots have developed gradually in the fields of portability, high precision, and low noise level due to their unique advantages of low noise and low energy consumption. This paper proposes an electromagnetically driven elastomer, using gelatin and glycerol (GG) as matrix materials and a mixture of multiwalled carbon nanotubes (MWCNTs) and Ag NWs (MA) as the conductive medium. Inchworm-inspired and spider-inspired soft robots have been developed, demonstrating fast movement speed, flexibility, and loading performance.

Constructing High-Performance Yarn-Shaped Electrodes via Twisting-after-Coating Technique for Weavable Seawater Battery.

Seawater batteries (SWBs) are green aqueous power sources with great potential in marine applications. So far, SWBs are mainly built on rigid substrates, which hinders their adaptability to marine textile applications. Herein, we constructed a rechargeable yarn-shaped SWB consisting of nickel hexacyanoferrate (Ni-HCF)-modified carbon yarn (positive electrode), glass fiber diaphragm, and polyimide (PI)-modified carbon yarn (negative electrode).

MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.

Objectives: To investigate the role and mechanism of MAPK14/AIFM2 pathway in Ang II-induced atrial fibrillation in rats.

Methods: A rat model of AF was established for in vivo experiments and HL-1 cells were treated with Ang II to develop an in vitro model. In addition, HL1 cells overexpressing AIFM2 (oeAIFM2) were constructed.

Projections of urban land exposure to drought and flood in China.

With global warming, the risk of human exposure to extreme climates increases, profoundly impacting sustainable development. Using rapidly developing China as an example, this study estimates the exposure of urban land to drought and flood based on historical and future climate and land data. The results show that the area of urban land exposed to drought in China generally decreases in the future.