Deptor protects against myocardial ischemia-reperfusion injury by regulating the mTOR signaling and autophagy.

Deptor knockout mice were constructed by crossing Deptor Floxp3 mice with myh6 Cre mice, establishing a myocardial ischemia-reperfusion (I/R) model. Deptor knockout mice exhibited significantly increased myocardial infarction size and increased myocardial apoptosis in vivo. ELISA analysis indicated that the expression of CK-MB, LDH, and CtnT/I was significantly higher in the Deptor knockout mice.

Seasonal hydrological variation impacts nitrogen speciation and enhances bioavailability in plateau lake sediments.

Global warming has intensified the distinction between dry and wet seasons in monsoonal climates. The synergistic effect of high temperatures and rainfall during the wet season promotes the release of endogenous nitrogen (N) and eutrophication within lake ecosystems. However, the seasonal variations in sediments N speciation and bioavailability, and their intrinsic connection to release potential, remain unclear.

A Targeted Proteomics Approach Reveals a Serum Protein Signature as a Diagnostic Biomarker for Colorectal Cancer.

Background: Circulating proteins secreted by tumors are an important source of cancer biomarkers. This study aims to investigate the changes in the content of tumor immune-related circulating proteins in peripheral blood from patients with colorectal cancer (CRC).

Methods: Olink's proximity extension assay was used to detect the levels of 92 tumor immune-related circulating proteins in peripheral blood from CRC patients.

A self-learning magnetic Hopfield neural network with intrinsic gradient descent adaption.

Physical neural networks (PNN) using physical materials and devices to mimic synapses and neurons offer an energy-efficient way to implement artificial neural networks. Yet, training PNN is difficult and heavily relies on external computing resources. An emerging concept to solve this issue is called physical self-learning that uses intrinsic physical parameters as trainable weights.

Notes on Arthrotus Motschulsky, 1857 from Nanling region of China (Coleoptera: Chrysomelidae), with descriptions of two new species.

Seventeen species of Arthrotus Motschulsky, 1857 (Coleoptera: Chrysomelidae: Galerucinae) from the Nanling area of China are reviewed, including two new species: A. hamatus sp. nov.

Carbon Dots with Charge Storage Ability Promote the Red Emission of TFB via Carrier Secondary Injection.

Dual-emission light-emitting diodes (DEDs) have great promising applications in medical imaging, optical communication, data storage, and three-dimensional display. The precise material design and advanced packaging technology for the construction of DEDs are still key challenges for practical application. We demonstrate a straightforward strategy to construct DEDs that deviates from traditional approaches, utilizing commercially available luminescent material of poly(9,9-dioctylfluorene---(4-(3-methylpropyl))diphenylamine) (TFB) and carbon dots (CDs).

Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis.

Aim: We investigated the mechanism by which the environmental toxin acrylamide (AM) promotes depression.

Methods: A depression mouse model was constructed using the chronic unpredictable mild stress method, AM was administered orally to simulate the exposure state. Depressive-like behavioral changes were assessed by open field test, elevated plus maze test, swimming test, and sucrose preference test.

Dedifferentiation of vascular smooth muscle cells upon vessel injury.

Highly differentiated mature vascular smooth muscle cells (VSMCs) are the predominant type of cells constituting arterial walls, which are essential for maintaining the structural and functional integrity of blood vessels. VSMCs demonstrate a notable degree of adaptability following vascular damage, a characteristic that plays a crucial role in the progression of vascular remodeling. Advances in single-cell RNA sequencing in both healthy and pathological vascular tissues have offered profound insights into the complexity of VSMCs, revealing a more intricate diversity than previously recognized.

Stabilized Carbon Radical-Mediated Assembly of Arylthianthrenium Salts, Alkenes and Amino Acid/Peptide Derivatives.

Efficiently assembling amino acids and peptides with bioactive molecules facilitates the modular and streamlined synthesis of a diverse library of peptide-related compounds. Particularly notable is their application in pharmaceutical development, leveraging site-selective late-stage functionalization. Here, a visible light-induced three-component reaction involving arylthianthrenium salts, amino acid/peptide derivatives, and alkenes are introduced.

Integrated electro-optic modulator on a lead zirconate titanate-silicon nitride heterogeneous platform.

Integrated electro-optic (EO) modulators are the core components of the optoelectronic information technology, and lithium niobate is currently the most widely used crystalline thin film material; however, finite EO coefficients limit the modulation efficiency of the modulators. In this Letter, we present an integrated EO modulator using a microring resonator on the lead zirconate titanate (PZT) and silicon nitride (SiN) heterogeneous platform. The microwave attenuation is reduced by using low loss tangent and dielectric constant SiN as the electrode substrate, achieving an EO bandwidth of 33 GHz.

Multi-band enhanced nonreciprocal thermal radiation based on Weyl semimetals.

Previous studies manifested that the majority of structures that exhibit nonreciprocal thermal radiation in the mid-infrared are capable of achieving either single-band strong nonreciprocity or multi-band weak nonreciprocity at a large incidence angle. However, few structures can realize multi-band strong nonreciprocity at a small incidence angle. To address such scientific issues, we propose a tunable nonreciprocal thermal emitter based on gallium arsenide (GaAs)/graphene/Weyl semimetal (WSM).

Variations of phosphorus in sediments and suspended particulate matter of a typical mesotrophic plateau lake and their contribution to eutrophication.

Internal phosphorus loading (IPL), as an important part of lake phosphorus cycle and the key to solve the eutrophication problem, is still an important cause of regional and seasonal algal blooms for some mesotrophic lakes located in plateau areas. We investigated the composition, distribution of P fractions in sediments and suspended particulate matter (SPM) of Erhai Lake, southwest China, and explored the relationships between environmental variables and spatial-temporal variations of P fractions. The total P (TP) in surface sediments ranged from 817 to 1216 mg/kg, with inert Ca-P (32%) and Res-P (24%) predominating, at a moderate level.

Enhanced in-situ sediment remediation by calcium peroxide coupled with zero-valent iron: Simultaneous nitrogen removal and phosphorus stabilization.

As the potential causes of eutrophication, nitrogen (N) and phosphorus (P) in sediments have received wide attention. However, few of the in-situ sediment remediation methods can achieve simultaneous N removal and P stabilization in sediments. In this study, different impacts on N, P and organic matter (OM) properties of sediments and overlying water with different proportions of calcium peroxide (CaO) coupling with zero-valent iron (ZVI) were explored through incubation experiments.

Quercetin@β-Cyclodextrin Conjugated Keratin/Polyurethane Biocomposite Mats for Infected Diabetic Wound Healing.

Chronic diabetic wounds suffer from severe complications caused by long-term high levels of oxidative stress and bacterial infection. Quercetin (Que) has excellent anti-inflammatory, antioxidant, and antibacterial activity, making it a promising drug to address the above issues. To exploit the benefits of Que in a more effective and sustained way to treat diabetic wounds, carboxymethyl β-cyclodextrin (CMCD) was synthesized and conjugated to keratin, then complexed with Que to form Que@Ker-CMCD inclusion, followed by electrospinning with polyurethane (PU) to afford Que@Ker-CMCD/PU mats.

Factors affecting community pharmacists' capacity to deliver pharmacy services in Zhengzhou, China: a cross-sectional study.

Objective: To assess the factors that affect the capacity of community pharmacists to deliver pharmacy services (PSs) in Zhengzhou, China.

Design: An online, cross-sectional survey was conducted.

Setting And Participants: A stratified sampling method was used to select community pharmacists for questionnaires.

Immune Indicator Changes in Hepatocellular Carcinoma Undergoing TACE Plus ICIs and Anti-VEGF Antibodies/TKIs: A Prognostic Biomarker Analysis.

Objective: To explore changing trends in circulating immune indicators of hepatocellular carcinoma (HCC) undergoing TACE plus immune checkpoint inhibitors (ICIs) and anti-VEGF antibodies/TKIs and to elucidate the relationship between immune response and tumor prognosis.

Materials: This single-center retrospective study included patients with unresectable HCC undergoing TACE plus ICIs and anti-VEGF antibodies/TKIs from March 11, 2019, to February 15, 2024. Peripheral blood samples were collected at baseline and every cycle, from which blood cell counts and immune indicators were analyzed.

Manipulative Single Electric Dipole with Spontaneous Translational Symmetry Breaking in a Two-Dimensional Crystal.

It is widely acknowledged that quantum entities with minimal mass cannot undergo spontaneous symmetry breaking due to strong quantum fluctuations. Here, we report the discovery of a positionally settled single electric dipole that can be manipulated and electrically polarized in a monolayer CoCl-graphite heterostructure, which demonstrates an unprecedented example of spontaneous lattice-translational-symmetry breaking. Scanning tunneling microscopy and atomic force microscopy show that the solitons are intrinsic paraelectric dipoles driven by synchronous charge-lattice distortion around individual CoCl octahedrons.