Associations of essential trace metals with telomere length in general population: a cross-sectional study.

This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations.

Association between particulate air pollution, physical activity, and the risk of osteoporosis in the UK Biobank.

As a major threat to global health, particulate air pollution has a great possibility of affecting bone metabolism. However, the results of limited studies examining the association between particulate air pollution and bone mineral density (BMD) as well as incident osteoporosis (OP) are conflicting, and the role of physical activity in the association above remains to be further studied. We evaluated the relationship between long-term exposure to Black Carbon (BC) and Particulate Matter (PM) (including PM (particles with aerodynamic diameter < 1 μm), PM (particles with aerodynamic diameter < 2.

Exploring a Favorable Tradeoff for Finding Every Efficient Path in Large-Scale Networks.

Multiobjective shortest path problem (MSPP) is one of the most critical issues in network optimization, aimed at identifying all efficient paths across conflicting objectives. Nowadays, existing methods face substantial bottlenecks in addressing the diverse preferences of decision makers and high spatiotemporal overhead caused by the calculation process, particularly in cases with large-scale networks. To overcome these obstacles, a generalized MSPP in large-scale networks is investigated with the aim of solving it with diverse preferences of decision makers satisfied and low spatiotemporal overhead.

Improving the Thermal Stability of Inverted Organic Solar Cells by Mitigating the Undesired MoO Diffusion toward Cathodes with a High-Ionization Potential Interface Layer.

Understanding the thermal degradation mechanism of organic solar cells (OSCs) and developing strategies to enhance their thermal stability are crucial before they can be commercialized. In this paper, we demonstrated that in a structure-inverted ITO/ZnO/PM6/L8-BO/TCTA/MoO/Ag solar cell, a thin 4,4',4″-tris(carbazol-9-yl)-triphenylamine (TCTA) film between MoO and PM6:L8-BO can significantly suppress the fast short circuit current () loss and the slow but continuous open circuit voltage () and fill factor (FF) decay upon 150 °C thermal annealing. XPS and TOF-SIMS results confirm that thermal annealing leads to the formation of (MoO) at the MoO/PM6/L8-BO interface and the diffusion of (MoO) through the photoactive layer.

NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8 T cell antitumor activity.

Introduction: Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer-related mortality among women worldwide. Although NADPH oxidase 4 (NOX4) has been implicated in various oncogenic processes, its exact function in breast cancer progression, metabolic reprogramming, and immune modulation remains unclear.

Methods: We used murine 4T1 and EO771 breast cancer models to generate NOX4 knockout (KO) cell lines via CRISPR/Cas9.

Effect of Interaction of ATG7 and Plasma Metal Concentrations on Cognitive Impairment in Rural China.

The objective of this study is to explore the association of plasma metal concentrations with impaired cognitive function in different genotypes of ATG7 using multiple models. A cross-sectional survey was conducted in rural China among 994 individuals aged 30 years or older. Cognitive function was assessed using the Mini-Mental State Examination (MMSE).

Mammary hibernoma: A rare case report of a benign tumor.

Introduction: Hibernoma is a rare benign soft-tissue tumor derived from vestigial brown adipose tissue. Mammary hibernoma is a rare entity that is usually misdiagnosed clinically and radiologically as lipoma or liposarcoma.

Presentation Of Case: We report a rare entity by dscribing the clinical, radiological and pathological features in a patient as well as the differential diagnoses and treatment.

Novel Polymer Gel Lubricant Functionalized with a Phosphate Anion for Friction Reduction and Film Thickness Enhancement in Multiple Lubrication Conditions.

In this study, a supramolecular polymer gelator functionalized with a phosphate anion, PMUS-P, has been successfully synthesized through radical polymerization, and its physicochemical, rheological properties and tribological performance were carefully evaluated as a gel lubricant formed through non-covalent self-assembly in 500SN base oil. The results showed that the gel has a dense network structure, providing excellent stability and mechanical strength. Additionally, the PMUS-P gel exhibits good shear-thinning behavior and excellent creep recovery, effectively avoiding the volatility of lubricants.

Hsa_circ_0000105 promotes nasopharyngeal carcinoma malignancy by miR-541-3p/S100A11 axis.

Objective: This study was to investigate whether hsa_circ_0000105 is involved in the process of regulating Nasopharyngeal Carcinoma (NPC) biological behaviors and to reveal the molecular mechanism.

Methods: NPC tissues and normal tissues were collected, and NPC cell lines and normal control cell lines were obtained. hsa_circ_0000105/miR-541-3p/S100A11 was evaluated by RT-qPCR or Western blot.

Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences.

Background: While current epidemiological studies have documented associations between environmental metals and renal dysfunction, the majority have concentrated on plasma metal levels. The relationship between urinary metal exposure and chronic kidney disease (CKD) remains contentious, particularly within specific demographic groups.

Methods: This cross-sectional study included 2919 rural Chinese adults recruited between 2018 and 2019.

Epitaxial Electrodeposition of Zinc on Different Single Crystal Copper Substrates for High Performance Aqueous Batteries.

The aqueous zinc metal battery holds great potential for large-scale energy storage due to its safety, low cost, and high theoretical capacity. However, challenges such as corrosion and dendritic growth necessitate controlled zinc deposition. This study employs epitaxy to achieve large-area, dense, and ultraflat zinc plating on textured copper foil.

Hypoxia Promotes Malignant Progression of Colorectal Cancer by Inducing POSTN Cancer-Associated Fibroblast Formation.

Colorectal cancer (CRC) is one of the most common malignancies. Hypoxia can promote the occurrence and development of CRC. However, how hypoxia regulates the CRC immune microenvironment needs to be further explored.

Effects of axillary dose restriction on plan quality and acute radiation dermatitis in breast cancer radiotherapy.

Axillary dose restriction (ADR) is rarely implemented in breast cancer radiotherapy by radiation oncologists to minimize exposure to organs at risk (OARs), particularly the axilla. This prospective randomized controlled study aims to evaluate the efficacy of ADR in improving plan quality (PQ) and its impact on acute radiation dermatitis (ARD) in breast cancer radiotherapy. The study recruited breast cancer patients who required postoperative radiotherapy but did not have an indication for axillary irradiation.

Genome-Wide Identification and Expression Analysis of Gene Family Under Various Nitrogen Conditions in Avocado ( Mill.).

Avocado is an important economic fruit tree that requires a lot of nitrogen (N) to support growth and development. Nitrate transporter (NRT) gene family plays an essential role in N uptake and use in plants. However, no systematic identification of the NRT gene family has been reported in avocado.

NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer.

In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.

Interactions of a PFOS/sodium nitrite mixture in Chinese mitten crab (Eriocheir sinensis): Impacts on survival, growth, behavior, energy metabolism and hepatopancreas transcriptome.

Perfluorooctanesulfonic acid (PFOS) and sodium nitrite may have complex adverse effects on aquatic animals. This study assessed the interactive effects of PFOS and sodium nitrite on Chinese mitten crab (Eriocheir sinensis). A 2 × 3 factorial experiment with 0, 0.

The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007-2018.

Objective: The dietary index for gut microbiota (DI-GM) is a newly proposed metric for assessing diet quality, and its relationship with biological age is unclear. We hypothesize that consuming foods conducive to a healthy gut microbiota environment may decelerate aging.

Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2018.

Radical Alkylcyanation of 1,6-Enynes with Isonitriles as Bifunctional Reagents.

We report a radical cyano-cyclization of 1,6-enynes with isonitriles via photochemically driven nickel catalysis, forging alkenyl nitrile-tethered γ-lactams under mild conditions. This reaction leverages the photoexcitation of generated nickel (isonitrile) species to facilitate isonitriles serving as alkyl radical precursors and cyanide sources. The reaction accommodates a wide range of substrates, exhibiting excellent regioselectivity and / stereoselectivity.

Comparative study on static and dynamic digest characteristics of oat β-Glucan and β-Gluco-Oligosaccharides.

Both oat β-glucans (OGs) and their hydrolyzed counterparts, oat β-gluco-oligosaccharides (OGOs), are dietary fibers indigestible by humans. They serve as substrates for the colonic intestinal flora, exhibiting potential prebiotic properties. This study, through in vitro digestion simulation, found that OGs and OGOs are not degraded and can safely pass through the upper digestive tract to reach the colon.

Assessing the Co-Exposure Patterns of Volatile Organic Compounds and the Risk of Hyperuricemia: An Analysis of the National Health and Nutrition Examination Survey 2003-2012.

Background: Co-exposure to multiple volatile organic compounds (VOCs) is common in daily life. However, few studies have evaluated the associations between the patterns of simultaneous exposure to multiple VOCs and the risk of hyperuricemia.

Methods: This study included 7490 adults from the National Health and Nutrition Examination Survey conducted between 2003 and 2012.

Hyperconjugation-controlled molecular conformation weakens lithium-ion solvation and stabilizes lithium metal anodes.

Tuning the solvation structure of lithium ions electrolyte engineering has proven effective for lithium metal (Li) anodes. Further advancement that bypasses the trial-and-error practice relies on the establishment of molecular design principles. Expanding the scope of our previous work on solvent fluorination, we report here an alternative design principle for non-fluorinated solvents, which potentially have reduced cost, environmental impact, and toxicity.

A Comprehensive Nomogram Integrating Phonocardiogram and Echocardiogram Features for the Diagnosis of Heart Failure With Preserved Ejection Fraction.

Background: Heart failure with preserved ejection fraction (HFpEF) is associated with high hospitalization and mortality rates, representing a significant healthcare burden. This study aims to utilize various information including echocardiogram and phonocardiogram to construct and validate a nomogram, assisting in clinical decision-making.

Methods: This study analyzed 204 patients (68 HFpEF and 136 non-HFpEF) from the First Affiliated Hospital of Chongqing Medical University.