Publications by authors named "Jian Pan"

Neuroblastoma (NB), a common infantile neuroendocrine tumor, presents a substantial therapeutic challenge when MYCN is amplified. Given that the protein structure of N-Myc is disordered, we utilized Alphafold for prediction and GROMACS for optimization of the N-Myc structure, thereby improving the reliability of the predicted structure. The publicly available datasets GSE49710 and GSE73517 were adopted, which contain the transcriptome data of clinical samples from 598 NB patients.

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Leukemia is characterized by multiple rearrangements of signal transduction genes and overexpression of nonmutated genes, such as transcription factors (TFs) genes. Super-enhancers (SEs) are prevalent in human cancers and are associated with the accumulation of numerous core TFs. SEs drive the expression of core TF genes by delivering robust transcriptional activation signals.

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Backgrounds: It has been regarded as an essential treatment option for diabetic nephropathy (DN) in Traditional Chinese medicine. Previous studies have demonstrated the anti-DN efficacy of Schisandra chinensis Fruit Mixture (SM); however, a comprehensive chemical fingerprint is still uncertain, and its mechanism of action, especially the potential therapeutic targets of anti-DN, needs to be further elucidated.

Objective: Potential mechanisms of SM action on DN were explored through network pharmacology and experimental validation.

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Background: Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and therapeutic resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through super-enhancers can establish core transcriptional regulatory circuits (CRCs) that modulate oncogene expression programs.

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Cold atmospheric plasma (CAP) has emerged as a promising therapeutic tool for wound healing and tissue regeneration. However, the clinical application of CAP faces challenges, particularly the need for repeated treatments to maintain therapeutic efficacy and the difficulty in controlling the release of reactive oxygen and nitrogen species (ROS/RNS), which can cause tissue damage at high concentrations. In this study, we developed a controlled-release system by integrating CAP with a skin bionics gelatin scaffold (CAP-GS), enabling the sustained, localized release of CAP without the need for repeated applications.

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The photovoltaic-alkaline water (PV-AW) electrolysis system offers an appealing approach for large-scale green hydrogen generation. However, current PV-AW systems suffer from low solar-to-hydrogen (STH) conversion efficiencies (e.g.

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This study investigates the process mechanisms for preparing 4N8 high-purity quartz powder from high-silicon iron ore tailings. Silicon concentrate obtained by wet high-intensity magnetic separation was used as the raw material, with impurities removed through a two-stage acid leaching process. The effects of acid concentration, temperature, time, and liquid-solid ratio on impurity removal were examined.

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Objective: The impact of lipid-lowering medications on chronic kidney disease (CKD) remains a subject of debate. This Mendelian randomization (MR) study aims to elucidate the potential effects of lipid-lowering drug targets on CKD development.

Methods: We extracted 11 genetic variants encoding targets of lipid-lowering drugs from published genome-wide association study (GWAS) summary statistics, encompassing LDLR, HMGCR, PCSK9, NPC1L1, APOB, ABCG5/ABCG8, LPL, APOC3, ANGPTL3, and PPARA.

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Background/purpose: Bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication arising from the use of bisphosphonates (BPs), inflicts long-term suffering on patients. Currently, there is still a lack of effective treatments. This study aimed to explore the preventive effects of propranolol (PRO) on BRONJ in vitro and in vivo, given PRO's potential in bone health enhancement.

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Objective: Rosacea is a common chronic inflammatory disorder primarily affecting the face. While inflammatory factors are known to play a pivotal role in its pathogenesis, their causal relationship with rosacea remains unclear. This study employed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal links between systemic inflammatory regulators and rosacea.

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Purpose: This study aims to evaluate the effectiveness and safety of prophylactic hyperthermic intraperitoneal chemotherapy (P-HIPEC) in patients with locally advanced gastric cancer (AGC) after laparoscopic radical gastrectomy. Additionally, it explores how the frequency and timing of P-HIPEC influence treatment outcomes.

Methods: A retrospective analysis was conducted on 227 patients with locally AGC who underwent laparoscopic surgery at Maoming People's Hospital from January 2016 to December 2022.

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Background: Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment (RCT), of autotransplanted teeth in an up-to-6-year follow-up cohort of 167 teeth in Southern China.

Methods: We enrolled adult patients from the Southern Medical University-Shenzhen Stomatology Hospital between 2017 and 2023.

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Cell cycle dysregulation and the corresponding metabolic reprogramming play significant roles in tumor development and progression. CDK9, a kinase that regulates gene transcription and cell cycle, also induces oncogene transcription and abnormal cell cycle in AML cells. The function of CDK9 for gene regulation in AML cells requires further exploration.

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Article Synopsis
  • Postoperative cognitive dysfunction (POCD) is a common issue that negatively impacts life quality, especially in patients with ischemic stroke.
  • The study identifies TREM2 as a crucial factor that helps protect the brain by regulating neuroinflammation through the PI3K/Akt signaling pathway.
  • Using a mouse model, we found that an enriched environment can improve cognitive function after surgery by boosting TREM2 expression and reducing inflammation, highlighting TREM2's vital role in this process.
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Cisplatin-based neoadjuvant chemotherapy is first-line strategy to inhibit progression and metastasis of muscle-invasive bladder cancer (MIBC). However, its clinical efficacy is often limited by drug resistance and severe systemic side effects, highlighting the urgent need for innovative therapeutic approaches. Despite advancements in cisplatin-based regimens, research on intravesical cisplatin delivery systems remains scarce.

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Kawasaki disease (KD), characterized by systematic vasculitis, is a leading cause of pediatric heart disease. Although recent studies have highlighted the critical role of deubiquitinases in vascular pathophysiology, their specific contribution to KD remains largely unknown. Herein, we investigated the function of the deubiquitinase USP7 in both KD patients and a CAWS-induced KD murine model.

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The selective androgen receptor (AR) modulator YK11 promotes the anabolism of muscle cells and osteoblastic precursor cells. However, its effects on bone marrow-derived mesenchymal stem cells (BMSCs) and the repair of cranial bone defects are unknown. Here, the effects of different concentrations of YK11 on the osteogenic differentiation of BMSCs were determined.

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Article Synopsis
  • Medication-related osteonecrosis of the jaw (MRONJ) results from systemic disease treatments, with current diagnosis and treatment methods being largely empirical and lacking consensus in China.
  • An expert panel from 11 medical institutions conducted a literature review to establish clearer definitions, risk factors, and treatment strategies for MRONJ.
  • They recommend that MRONJ diagnosis rely on medication history and clinical signs, advocate surgical options for symptomatic cases, and emphasize a multidisciplinary approach for better treatment outcomes.
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Article Synopsis
  • Secondary lymphedema is a chronic condition causing limb deformities and dysfunction, and while traditional treatments exist, they are not curative.
  • This study explores the use of engineered adipose-derived stem cells (ADSCs) for treating lymphedema, specifically focusing on the role of a protein called Yes-associated protein (YAP).
  • Results showed that manipulating YAP expression in ADSCs enhanced their effectiveness, leading to improved lymphatic vessel formation and reduced fibrosis, suggesting a potential new therapeutic approach for lymphedema.
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The preparation of high-performance electrode materials from metallurgical solid waste is an effective strategy to address current energy and environmental challenges. This study utilizes a mixed acid leaching and ultrasound-assisted precipitation process to extract valuable metallic iron from titanium-extraction tailings (TET) to produce high-purity nano-FePO electrode material precursors with unique crystal structures. A leaching efficiency of 95.

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Background: This study aims to develop a hierarchical classification method to automatically assess the severity of knee osteoarthritis (KOA).

Methods: This retrospective study recruited 4074 patients. Clinical diagnostic indicators and clinical diagnostic processes were applied to develop a hierarchical classification method that involved four sub-task classifications.

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Article Synopsis
  • Super enhancers (SEs) are essential for cell identity and can activate oncogenes in cancer, particularly in T-cell acute lymphoblastic leukemia (T-ALL).
  • A new SE has been found in T-ALL that regulates the gene IRF2BP2, influenced by key transcription factors like ERG and ELF1.
  • While IRF2BP2 does not significantly affect normal T cell development, it is vital for T-ALL cell growth and survival, implicating it as a potential target for treatment options.
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Clinical studies intensively highlight two critical brain regions, i,e, dorsal lateral prefrontal cortex (DLPFC) (target node) and subgenual anterior cingulate cortex (sgACC) (indirect target node) for the treatment of neuroimaging-guided repetitive transcranial magnetic stimulation (rTMS) in major depressive disorder (MDD). However, it remains unclear whether the clinical rTMS treatment could modulate the activity of the target and indirect target nodes in MDD patients. We aim to identify the rTMS-induced alteration of brain local and functional connectivity (FC) activities in the target and indirect target nodes.

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