Publications by authors named "Jian Jun Zhu"
Receptor-interacting protein kinase 1 (RIPK1) contributes to necroptosis. Our previous study showed that pharmacological or genetic inhibition of RIPK1 protects against ischemic stroke-induced astrocyte injury. In this study, we investigated the molecular mechanisms underlying RIPK1-mediated astrocyte injury in vitro and in vivo.
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- The study focused on pediatric liver-transplanted patients infected with the Omicron variant BA.2 during the COVID-19 outbreak in Shanghai from March to October 2022.
- Five patients with varying primary diseases showed symptoms like fever upon infection, with the duration of illness lasting around 29 days, categorized as mild to moderate cases.
- Findings indicate that post-transplant immunosuppression can prolong virus clearance and raise the risk of relapse but does not influence the severity or symptom duration; patients often recover well with adjusted immunosuppressant therapy.
Purpose: The meta-analysis was conducted to evaluate the safety and feasibility of pure laparoscopic left lateral hepatectomy in comparison with open approach for pediatric living donor liver transplantation (LDLT).
Methods: A systemic literature survey was performed by searching the PubMed, EMBASE and Cochrane Library databases for articles that compared pure laparoscopic left lateral living donor hepatectomy (LLDH) and open left lateral living donor hepatectomy (OLDH) by November 2021. Meta-analysis was performed to assess donors' and recipients' perioperative outcomes using RevMan 5.
Article Synopsis
- Researchers discovered new, effective insecticides from natural products, focusing on Celangulin V, which targets a specific enzyme in insects.
- They synthesized thirty-seven sulfonamide derivatives to find cost-effective compounds with high insecticidal efficiency.
- Several derivatives showed better insecticidal activity against larvae than Celangulin V, providing potential new insecticide options based on their unique mechanism of action.
Article Synopsis
- Celangulin V, a natural sesquiterpene polyester, has shown anti-insect activity through a unique mechanism targeting the H subunit of V-ATPase in insect midguts.
- Researchers synthesized thirty-two benzene sulfonamide derivatives to find cost-effective insecticides, with several compounds (C2, C4, C5, C6, and C8) demonstrating significantly higher efficacy than Celangulin V, with lower LC50 values.
- Molecular docking studies suggest that these new sulfonamide compounds effectively interact with the H subunit of V-ATPase, making them promising candidates for developing efficient insecticidal agents.
Article Synopsis
- The study focuses on enhancing the diversity of 1,3,4-oxadiazole-2-carbohydrazides by adding small chemical fragments to identify new succinate dehydrogenase inhibitors (SDHIs).
- Bioassay results show that these new compounds have antifungal effects, with some being more effective than traditional pesticides like carbendazim, particularly one compound that had exceptionally strong activity against a specific fungus.
- Besides antifungal properties, the compounds also exhibited anti-oomycete and antibacterial activity, suggesting they have broad potential as new pesticide candidates.
Background: Resistant hypertension (RH) has always been a difficult problem in clinical diagnosis and treatment. At present, there is no recognized safe and effective minimally invasive treatment.
Case Summary: An 80-year-old woman was admitted to hospital due to trigeminal neuralgia (TN).
Exploring factors of the sustainable supply chain in the post-COVID-19 pandemic: SWARA approach.
Environ Sci Pollut Res Int
March 2023
Article Synopsis
- - The research focuses on ways to enhance sustainable supply chain survivability (SSCS) amidst the disruptions caused by the COVID-19 lockdowns, which affected logistics and manufacturing operations.
- - It emphasizes adapting sustainable supply chain (SSC) practices by identifying and classifying key elements using the stepwise weight assessment ratio analysis (SWARA) approach to improve SSC during and after the pandemic.
- - The findings highlight that the effectiveness of the supply chain network is crucial for managing relationships between suppliers and buyers, ultimately aiming for better SSCS outcomes and a healthier business environment.
Article Synopsis
- Researchers synthesized new agricultural chemicals called pyrazole hydrazide derivatives, which showed potential as multifunctional pesticides with antifungal, antibacterial, and anti-oomycete properties.
- The synthesized compounds were tested against various fungi and proved effective, with some achieving high protective and curative rates comparable to existing fungicides in controlling corn scab.
- Further studies indicated that these compounds could inhibit important enzymes, making them promising candidates for future development as versatile agricultural chemicals.
Plant bacterial diseases can potentially damage agricultural products around the world, and few effective bactericides can manage these infections. Herein, to sequentially explore highly effective antibacterial alternatives, 1,2,3-triazole-tailored carbazoles were rationally fabricated. These compounds could suppress the growth of three main intractable pathogens including pv (), pv (), and pv () with lower EC values of 3.
View Article and Find Full Text PDF[Effect of density and directional cultivation on yield, quality and benefit of Nuomi yam].
Zhongguo Zhong Yao Za Zhi
November 2020
A split-plot experiment was conducted to study the optimum planting density of Nuomi yam in directional groove shallow cultivation. Nuomi yam was the main local cultivar of Dioscorea. The study of this paper may help to give valuable instructions of local production.
View Article and Find Full Text PDFStudy on effects of co-solvents on the structure of DhaA by molecular dynamics simulation.
J Biomol Struct Dyn
October 2021
Article Synopsis
- The study focuses on how different co-solvents impact enzyme activity, specifically looking at DhaA in acetonitrile and tetrahydrofuran.
- Molecular dynamics simulations showed that these solvents induce structural changes in the enzyme through interactions like van der Waals forces.
- The research found that acetonitrile interacts more directly with the catalytic site of DhaA, while tetrahydrofuran surrounds it, leading to differing effects on the enzyme's function.
Article Synopsis
- Mare milk, sourced from female horses (mares), is traditionally used to produce a fermented drink called Chigee, which is recognized for its health benefits in Mongolian medicine.
- The study analyzed 188 samples of mare milk and Chigee, revealing that fermentation significantly reduces lactose levels while increasing acidity and alcohol content.
- Findings also showed variations in lactic acid bacteria and yeast counts in Chigee, with higher acidity levels helping to inhibit harmful bacteria, paving the way for standardizing production processes for industrial Chigee in China.
Article Synopsis
- - A new type of antifungal compound, 1,3,4-oxadiazole-2-carbohydrazide, has shown strong effectiveness against various fungi and oomycetes, outperforming some established antifungals like fluopyram.
- - The compounds demonstrated low effective concentration (EC) values ranging from 0.486 to 0.799 μg/mL, making them potentially valuable alternatives in combating fungal infections.
- - Molecular docking studies indicate that these compounds target succinate dehydrogenase (SDH), supported by significant inhibition of SDH activity, establishing a promising framework for developing new antifungal agents.
Article Synopsis
- The study focuses on the complex mechanisms behind cancer-induced bone pain (CIBP), specifically highlighting the role of glutamate receptors and the protein SAP102.
- SAP102 helps anchor glutamate receptors in neurons, but its exact impact on pain sensitivity (hyperalgesia) in CIBP had not been previously understood.
- Experimental results show that reducing SAP102 levels in spinal neurons can significantly decrease abnormal pain responses in rats with CIBP, suggesting SAP102's crucial involvement in pain mechanisms related to bone cancer.
Article Synopsis
- The study analyzes traditionally fermented vrum from Inner Mongolia, highlighting its unique composition with 34.5% moisture, 44.9% fat, and 10.6% protein.
- It identifies key microbial communities involved in fermentation, finding high counts of lactic acid bacteria and various fungal species, with Lactococcus, Lactobacillus, and Dipodascus being the most prevalent.
- The research aims to enhance understanding of vrum's nutritional and functional properties, potentially aiding in the development of probiotics and other health-promoting materials.
Article Synopsis
- The study examined the growth effects of different substrate mixtures (peat soil, river sand, peanut shell) on three origins of Anoectochilus roburghii, measuring factors such as survival rate, plant height, and root characteristics.
- Results indicated that a substrate ratio of 4:2:2 yielded the highest survival rate and the best growth metrics for A. roburghii across all origins.
- Additionally, varying substrate ratios impacted the levels of polysaccharides, flavonoids, and polyphenols in the plants, with specific ratios favoring the accumulation of these compounds differently for each species.
Koumiss is notable for its nutritional functions, and microorganisms in koumiss determine its versatility. In this study, the bacterial and fungal community structures in traditional koumiss from Inner Mongolia, China, were investigated. Our results demonstrated that 6 bacterial phyla represented by 126 genera and 49 species and 3 fungal phyla represented by 59 genera and 57 species were detected in 11 samples of artisanal koumiss.
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- The study aimed to explore the relationship between lactate levels and lactate clearance with neurological outcomes in cardiac arrest patients, due to inconsistent findings in prior research.
- A meta-analysis was conducted, involving 23 studies with 6,720 patients to evaluate lactate measurements at various time points and their correlation with recovery outcomes.
- Findings showed that lower lactate levels upon admission were linked to better neurological outcomes, while lactate clearance only showed a significant association at 24 hours, suggesting that lactate levels are a more reliable predictor than lactate clearance.
Four-Subtest Index-based Short Form of WAIS-IV: Psychometric Properties and Clinical Utility.
Arch Clin Neuropsychol
February 2019
Article Synopsis
- The study evaluates the psychometric properties of a short form of the Wechsler Adult Intelligence Scale (WAIS-IV) called SF4, specifically its effectiveness in clinical settings in China.
- A sample of 1,757 adults and 239 clinical patients demonstrated strong reliability and correlation results for the SF4, making it a useful tool for quick intelligence assessments.
- The study also found a significant interaction between gender and IQ levels, suggesting that SF4 may underestimate intelligence in females with high IQ scores compared to males, highlighting the need for careful interpretation in clinical use.
miR-124 inhibits progression of hepatocarcinoma by targeting KLF4 and promises a novel diagnostic marker.
Artif Cells Nanomed Biotechnol
May 2019
Hepatocarcinoma is one of the most lethal malignancy haunting the Chinese population, which is partially due to the difficulties in diagnosis at an early stage. The search for a biomarker that could signify the presence and progress of hepatocarcinoma is never ended. MicroRNAs are 22-nt RNAs that could bind to 3' UTR of target mRNAs, mediating degradation of mRNAs or inhibiting the translation.
View Article and Find Full Text PDFObjective: The study aims to explore the relationship between expressions of HER2 and JAK/STAT3-SOCS3 signaling pathway and clinicopathological features and prognosis of ovarian cancer (OC).
Methods: A total of 136 OC patients were collected. Immunohistochemistry was applied to measure the expressions of STAT3, p-STAT3, SOCS3, HER2 and p-HER2 in the tumor tissues and adjacent normal tissues.
[Changes in the growth and photosynthesis of cotton seedlings under progressive drought after saltwater irrigation].
Ying Yong Sheng Tai Xue Bao
December 2014
Pot grown cotton plants were watered with saltwater (NaCl solutions of different concentrations), followed by a duration of progressive drought stress. The changes in plantlet growth, photosynthetic rate, chlorophyll fluorescence were measured, and the water status of the plantlets, such as relative water content, water potential, osmotic potential, the Na+ and K+ contents in leaves during drought were measured and analyzed, in order to get an insight into the role of Na+ played in the adaptation of cotton to drought stress. The results showed that the growth of the plantlets was significantly inhibited, the net photosynthetic rates were remarkably lowered by the drought stress, but the plant height, biomass, net photosynthetic rate and Fv/Fm values in the cotton plants watered with 25-100 mmol x L(-1) x NaCl solution under drought stress were significantly higher than those watered with water under the same intensity of drought stress.
View Article and Find Full Text PDFObjective: The aim of this study was to analyze the incidence and risk factors of de novo hepatitis B virus (HBV) infection from hepatitis B core antibody (anti-HBc)-positive donors in pediatric living donor liver transplantation (LDLT).
Methods: We retrospectively analyzed 46 recipients without pre-liver transplantation (LT) HBV infection evidence who underwent LDLT from October 2006 to May 2011 in our center. HBV markers, including hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), anti-HBc, hepatitis B e antigen (HBeAg) and antibody (anti-HBe) were determined in both donors and recipients before LT and in recipients after LT.