Publications by authors named "Jian Jun Chen"
Naturally Occurring Cleistanthane Diterpenoids and Their Biological Activities.
Chem Biodivers
December 2024
Cleistanthane diterpenoids, an important class of active natural products, are characterized by a 6/6/6 tricycle system and contain a variety of functional groups. Studies have shown that cleistanthane diterpenoids are widespread in various higher plants and endophytic fungi and exhibit a wide range of biological activities. This review provides extensive coverage of naturally occurring cleistanthane diterpenoids discovered from 1973 to 2024 and sheds light on the sources, structures, biological effects, and primary molecular mechanisms of them and provides a useful reference for the further study and development of these compounds.
View Article and Find Full Text PDFPreventing the progression of acute pancreatitis (AP) to severe acute pancreatitis (SAP) is crucial for AP patients. The use of clinical parameters in laboratory facilities for predicting SAP can be rapid, efficient, and cost-effective. This study aimed to investigate the predictive and prognostic value of collected clinical detection parameters, such as serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) levels, and their ratios, such as ALP-to-hemoglobin (Hb) and LDH-to-Hb ratios, for the prediction of SAP occurrence, complications, and mortality.
View Article and Find Full Text PDFArticle Synopsis
- Six new compounds called Euphohelinodes D-I (1-6), which are ent-abietane lactones, were discovered from the plant E. helioscopia, known for its anti-inflammatory properties.
- The structures of these compounds were analyzed using advanced techniques like spectroscopic data, X-ray diffraction, and ECD analysis.
- The most effective compound, euphohelinode H (5), reduced nitric oxide production in inflammatory cells and inhibited key enzymes linked to inflammation via the NF-κB signaling pathway, showing potential for treating inflammatory conditions.
Purpose: Up to now, there is no generally accepted biomarker to indicate the clinical response of immunotherapy. This study mainly analyzed the correlation between eosinophil cationic protein-myeloperoxidase (ECP-MPO) test papers and other immunotherapy indices in subcutaneous immunotherapy of dust mites and to explore whether the test paper can be used as an auxiliary index to quickly evaluate the efficacy of immunotherapy.
Patients And Methods: This study included 53 participants who received subcutaneous immunotherapy at the allergy clinic of Renmin Hospital of Wuhan University and 28 control participants.
Article Synopsis
- - The text discusses a rare gram-negative bacterium known for its corrosive and pathogenic characteristics, which can inhabit the oral, nasopharyngeal, gastrointestinal, and urogenital regions in humans and animals, but is challenging to diagnose due to slow growth and uneven hospital resources in China.
- - A case study involving a 67-year-old male patient is highlighted, who presented with symptoms like cough and dyspnea, leading to the discovery of empyema and a correlation with the aforementioned bacterium.
- - Despite receiving antimicrobial treatment, the patient unfortunately passed away after 22 days in the hospital, underscoring the severity of infections associated with this specific bacterium.
[Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs （2024, Chengdu）].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
June 2024
Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease （N-ERD） is a chronic respiratory disease characterized by eosinophilic inflammation, featuring chronic rhinosinusitis （CRS）, asthma, and intolerance to cyclooxygenase 1 （COX-1） inhibitors. The use of these medications can lead to an acute worsening of rhinitis and asthma symptoms. This condition has not yet received sufficient attention in China, with a high rate of misdiagnosis and a lack of related research.
View Article and Find Full Text PDFClinical study of enhanced recovery after surgery in laparoscopic appendectomy for acute appendicitis.
World J Gastrointest Surg
March 2024
Article Synopsis
- The study investigates the effectiveness of the Enhanced Recovery After Surgery (ERAS) protocol in improving recovery outcomes for patients undergoing laparoscopic appendectomy for acute appendicitis.
- It compares 120 patients, with one group following the ERAS protocol and the other receiving traditional treatment, measuring factors like hospitalization duration, costs, and pain levels.
- Results show that the ERAS group experienced faster recovery, shorter hospital stays, and lower costs, indicating that ERAS is a beneficial method for these surgeries.
Article Synopsis
- SARS-CoV-2 continues to evolve despite vaccination efforts, making the development of affordable vaccines for the Omicron variant crucial.
- A study tested a vaccine using a live Newcastle disease virus that expresses Omicron's spike protein in hamsters, administered either intranasally (IN) or intramuscularly (IM).
- Results showed that the vaccine elicited strong antibody responses and provided complete protection against the Omicron BA.1 variant, suggesting it could be a viable nasal vaccination option against similar strains.
Article Synopsis
- A study on Euphorbia helioscopia L. identified three new ent-atisane diterpenoids and five known compounds through various analytical techniques.
- The structures of the new compounds were determined using methods like NMR and X-ray crystallography, with one compound being notably rare due to a hydroxyl group.
- Bioactivity tests revealed that certain known compounds had significant anti-inflammatory effects by inhibiting NO production in a dose-dependent manner.
[Analysis of Prognosis and Therapeutic Effect of Patients with Thrombotic Thrombocytopenic Purpura].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2023
Article Synopsis
- The study retrospectively analyzed clinical and laboratory features of 59 patients with thrombotic thrombocytopenic purpura (TTP) to understand prognostic factors and treatment effectiveness during the acute phase of the disease.
- Most cases were acquired TTP, with a significant number showing decreased ADAMTS13 activity, highlighting differences between idiopathic and secondary forms of the disease.
- Factors like age, ALT/AST ratio, and the number and duration of therapeutic plasma exchanges were linked to patient survival and recovery outcomes.
Article Synopsis
- * This study focused on five cardiac glycosides extracted from plants, with lanatoside C (Lan C) identified as the most effective in inhibiting the growth and inducing apoptosis in CCA cells.
- * The mechanism of Lan C's anticancer activity involved increasing reactive oxygen species, altering mitochondrial potential, and modulating specific protein expressions, ultimately leading to reduced tumor growth without harming normal cells.
Article Synopsis
- - The study aimed to evaluate the effectiveness of measuring Eosinophilic cationic protein (ECP) and eosinophil percentage (EOS%) in nasal secretions for diagnosing different types of Chronic rhinosinusitis (CRS) and their link to clinical symptoms.
- - It involved comparing nasal secretions from patients with eosinophilic chronic rhinosinusitis (ECRS) to healthy individuals and non-eosinophilic CRS (NECRS), finding that ECRS patients had significantly higher ECP levels and eosinophil percentages.
- - The study concluded that ECP measurement in nasal secretions is a valuable, non-invasive method for diagnosing ECRS, showing stronger predictive potential compared to EOS
Article Synopsis
- - Three new diterpenoids, pedilanins A-C, with a unique carbon structure, were discovered from the plant Pedilanthus tithymaloides, along with nine new jatrophane diterpenoids and five known compounds.
- - The newly identified compounds feature an unusual tricyclo[10.3.0.0]pentadecane skeleton and some jatrophanes have a rare cyclic hemiketal substructure.
- - In biological tests, these compounds significantly reversed multidrug resistance in cancer cells, showing improvements from 17.9 to 396.8 times at a concentration of 10 μM, primarily by inhibiting the P-glycoprotein transporter function.
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive cancer that lacks effective noninvasive diagnostic methods, typically relying on invasive biopsies for pathology.
- Researchers utilized machine learning techniques, specifically random forest (RF) and artificial neural networks (ANN), to identify six key genes associated with HNSCC and to construct a diagnostic model named neuralHNSCC.
- The neuralHNSCC model showed a promising area under the curve (AUC) of 0.998 in initial tests and 0.734 in validation, indicating its potential for improving diagnostic capabilities and understanding immune cell differences in HNSCC compared to normal tissues.
Article Synopsis
- Researchers isolated 17 new diterpenoids, named phyllarheophols A-Q, from the plant Phyllanthus rheophyticus, along with 12 known compounds.
- The structural analysis of these compounds was conducted using spectroscopic techniques, single-crystal X-ray diffraction, and ECD analysis for accuracy.
- Anti-inflammatory effects were tested on macrophages, revealing that compounds phyllarheophol D and phyacioid B notably reduced cytokine levels and nitric oxide synthase via the NF-κB signaling pathway.
Chinese Expert Consensus on the Use of Biologics in Patients with Chronic Rhinosinusitis (2022, Zhuhai).
Hai-Yu Hong Teng-Yu Chen Qin-Tai Yang Yue-Qi Sun Feng-Hong Chen Jian-Jun Chen Cheng-Li Xu Yu-Cheng Yang
ORL J Otorhinolaryngol Relat Spec
June 2023
Background: Chronic rhinosinusitis (CRS) is a common inflammatory disease in otolaryngology, mainly manifested as nasal congestion, nasal discharge, facial pain/pressure, and smell disorder. CRS with nasal polyps (CRSwNP), an important phenotype of CRS, has a high recurrence rate even after receiving corticosteroids and/or functional endoscopic sinus surgery. In recent years, clinicians have focused on the application of biological agents in CRSwNP.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates how different inflammatory types of chronic rhinosinusitis (CRS) are linked to clinical symptoms and examines the use of specific biomarkers (MPO and ECP) in diagnosing these types.
- - Researchers collected data on symptoms and nasal secretions from CRS patients, finding distinct clinical scores between endotypes. They also measured levels of immune cells and biomarkers in both tissues and secretions.
- - Results indicate that certain biomarker levels can effectively differentiate between CRS endotypes, with MPO and ECP being valuable for diagnosis, suggesting a clear connection between clinical presentation and inflammatory endotypes.
Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice.
Front Cell Infect Microbiol
March 2023
Article Synopsis
- The study investigates how gut microbiota is linked to metabolism in relation to depression, focusing on the molecular mechanisms behind this relationship.
- Using a chronic social defeat stress model in mice, researchers identified differences in gut bacteria and metabolites between depressed and control groups.
- Results revealed that specific bacteria from the Firmicutes phylum and decreased tryptophan-related metabolites were associated with depressive behaviors, suggesting that tryptophan metabolism may play a key role in the gut-brain connection in depression.
Article Synopsis
- - Three new norditerpene lactones (euphohelides A-C) were discovered and isolated from the plants of L., along with 11 known analogs.
- - Euphohelide A features a unique tetracyclic structure, while euphohelides B and C have different dilactone tetracyclic configurations.
- - The new compounds demonstrated potential anti-inflammatory properties by significantly reducing LPS-induced nitric oxide release, likely through modulation of the NF-κB signaling pathway.
Article Synopsis
- - Two new azaphilones, named penimultiones A and B, were discovered along with seven existing compounds from the fungus Penicillium multicolor LZUC-S2.
- - The structures of these new compounds were determined using advanced spectroscopic techniques and chemical reactions.
- - When tested for antibacterial effects against five different bacteria, three compounds demonstrated strong activity, with minimum inhibitory concentrations (MIC) between 12.5 and 50.0 μg/mL.
Article Synopsis
- The study investigates the connection between gut microbiota and depression by examining the Gut-Liver-Brain axis in depressed mice, focusing on microbiota, lipid metabolism, and neurotransmitters.
- Using a mouse model subjected to chronic mild stress, researchers analyzed fecal, liver, and hippocampal samples to identify changes in microbiota composition and metabolic signatures.
- Significant differences were found in gut microbiota and lipid metabolites between depressed and control mice, suggesting that glycerophospholipid metabolism may link gut health and depression, with specific microbial families and neurotransmitters identified as critical factors.
Article Synopsis
- Regional land use changes significantly affect carbon storage in ecosystems, particularly in the source region of the Yellow River, highlighting the importance of predicting these impacts for sustainable development.
- From 2000 to 2020, carbon storage in the area increased by 11.59 million tons, mainly due to the expansion of wetlands and shifts in grassland coverage.
- Projections for 2040 indicate further carbon storage increases, with the natural change scenario showing a rise of 3.92 million tons and the ecological protection scenario yielding an even larger increase of 13.53 million tons, underscoring the need for informed land use management.
Article Synopsis
- Two new compounds, sagittacins F and G, were discovered from the plant Ligularia sagitta, along with a known isomer of sagittacin F.
- The structures of these compounds were identified using spectroscopic methods, and their configurations were confirmed through X-ray spectroscopy.
- Anti-inflammatory properties were tested, showing that compounds 2 and 3 could modestly inhibit nitric oxide production in cells, with specific concentrations needed to achieve this effect.
Article Synopsis
- Cardiac glycosides (CGs) are being studied as potential cancer treatments due to their diverse structures and strong biological effects.
- In the research, fifteen CGs were isolated from a plant, with three being new discoveries, and their structures were analyzed through various advanced scientific methods.
- The results showed that these CGs, particularly compound 1, had potent cytotoxic effects on cancer cell lines and interfered with the cell cycle, indicating potential for further development as cancer therapies.