Low-intensity transcranial ultrasound stimulation inhibits epileptic seizures in motor cortex by modulating hippocampus neural activity.

Prior studies indicate that applying low-intensity transcranial ultrasound stimulation (TUS) to the hippocampus can suppress epileptic seizures. Nevertheless, it is unclear how TUS regulates hippocampal neural activity, and whether and how epileptic discharges in the motor cortex are suppressed by modulating hippocampal neural activity. To explore the answers of above questions, ultrasound was utilized to investigate the responses to the aforementioned inquiries by stimulating the hippocampus of mice with penicillin-induced epilepsy, while simultaneously recording the local field potentials (LFPs) in the hippocampus and the motor cortex (M1) throughout the experiment.

An-Gong-Niu-Huang-Wan (AGNHW) regulates cerebral blood flow by improving hypoperfusion, cerebrovascular reactivity and microcirculation disturbances after stroke.

Background: The restoration of cerebrovascular regulation and improvement of cerebral blood flow in ischaemic regions are crucial for improving the clinical prognosis after stroke. An-Gong-Niu-Huang-Wan (AGNHW) is a famous traditional compound Chinese medicine that has been used for over 220 years to treat acute ischaemic stroke; however, its role in the regulation of cerebral blood flow is still unclear. The aim of the present study was to investigate the regulatory effect of AGNHW on cerebral blood flow and microcirculation after ischaemic stroke and to elucidate the underlying mechanisms involved.

Low-intensity transcranial ultrasound stimulation improves memory in vascular dementia by enhancing neuronal activity and promoting spine formation.

Memory is closely associated with neuronal activity and dendritic spine formation. Low-intensity transcranial ultrasound stimulation (TUS) improves the memory of individuals with vascular dementia (VD). However, it is unclear whether neuronal activity and dendritic spine formation under ultrasound stimulation are involved in memory improvement in VD.

Transcranial Ultrasound Stimulation Improves Memory Performance of Parkinsonian Mice.

Cognitive impairment is one of the most common non-motor symptoms of Parkinson's disease (PD). Previous studies have demonstrated that low-intensity transcranial ultrasound stimulation can significantly suppress the motor symptoms of PD. However, whether ultrasound stimulation can improve cognitive ability in PD and the related neural oscillation mechanism remain unclear to date.

Modulation effects of low-intensity transcranial ultrasound stimulation on the neuronal firing activity and synaptic plasticity of mice.

Low-intensity transcranial ultrasound stimulation (TUS) has been effective in modulating several neurological and psychiatric disorders. However, how TUS modulates neuronal firing activity and synaptic plasticity remains unclear. Thus, we behaviorally tested the whisker-dependent novel object discrimination ability in mice after ultrasound stimulation and examined the cortical neuronal firing activity and synaptic plasticity in awake mice after ultrasound stimulation by two-photon fluorescence imaging.