Research on the local path planning of an orchard mower based on safe corridor and quadratic programming.

Introduction: Path planning algorithms are challenging to implement with mobile robots in orchards due to kinematic constraints and unstructured environments with narrow and irregularly distributed obstacles.

Methods: To address these challenges and ensure operational safety, a local path planning method for orchard mowers is proposed in this study. This method accounts for the structural characteristics of the mowing operation route and utilizes a path-velocity decoupling method for local planning based on following the global reference operation route, which includes two innovations.

Novel gene mutation causes autosomal-dominant congenital cataract.

Aim: To identify disease-causative mutations in families with congenital cataract.

Methods: Two Chinese families with autosomal-dominant congenital cataract (ADCC) were recruited and underwent comprehensive eye examinations. Gene panel next-generation sequencing of common pathogenic genes of congenital cataract was performed in the proband of each family.

Selective Si-C(sp) bond cleavage of a silyl-bridged amido alkyl ligand in an yttrium complex.

Compared with Si-C(sp and sp) bonds bearing neighboring π-bond hyperconjugative interactions, the activation of robust Si-C(sp) bonds has proved to be a challenge. Herein, two distinct Si-C(sp) bond cleavages have been realized by rare-earth-mediated and nucleophilic addition of unsaturated substrates. The reactions of TpY[κ-(C,N)-CH(SiHPh)SiMeNSiMe](THF) (1) with CO or CS gave two endocyclic Si-C bond cleavage products, TpY[κ-(O,N)-OCCH(SiHPh)SiMeNSiMe](THF) (2) and TpY[κ-(S,N)-SSiMeNSiMe](THF) (3), respectively.

Cooperative Rare-Earth/Lithium-Mediated Conversion of White Phosphorus.

The rare-earth/lithium cooperative effect on functionalization of white phosphorus has been investigated. The reaction of diazabutadiene-supported yttrium hydride chelated a LiPPh molecule (LY ⋅ THF) (μ-H) [μ-PPh (Li)] (1, L=N,N'-di(2,6-diisopropylphenyl)-1,4-diazabutadiene) with P gave two novel mixed Y/Li multinuclear polyphosphorus complexes (LY ⋅ THF) [cyclo-P ]Li(THF) (2) and [Li(THF) ] [(LY ⋅ THF) (norborane-P )Li(THF)] (3), accompanied with the elimination of diphosphorus compound Ph PPPh (4) and H . However, the comparative reaction of yttrium hydride (LY ⋅ THF) (μ-H) with P afforded a trinuclear yttrium pyramid-P complex (LY ⋅ THF) (μ -P(PH) ) (5).

Aptamer Inhibits Tumor Growth by Leveraging Cellular Proteasomal Degradation System to Degrade c-Met in Mice.

Current action mechanisms for aptamer-based therapeutics depend on occupancy-driven pharmacology to mediate protein functions. We report a new mechanism where aptamers leverage cellular proteasomal degradation system to degrade proteins for cancer treatment. A DNA aptamer (hereinafter referred to as c-Met-Ap) binds to the extracellular domain of mesenchymal-epithelial transition factor (c-Met) and selectively induces c-Met phosphorylation at Y1003 and Y1349.

LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma.

Long non-coding RNAs (lncRNAs) play a crucial role in macrophage development but little is known about their role in asthma. Here, we investigated the role of lncRNA lncTRPM2-AS in asthma and found that lncTRPM2-AS participates in the promotion of macrophage inflammation. Downregulation of lncTRPM2-AS promoted apoptosis and inhibited proliferation and production of cytokines including IL-1β, IL-4, IL-6, IL-10, TNF-α, and TGF-β.

Polymorphisms and Circulating Plasma Protein Levels of Immune Checkpoints (CTLA-4 and PD-1) Are Associated With Posner-Schlossman Syndrome in Southern Chinese.

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) are well-known key immune checkpoints that play a crucial dampening effect on regulating T-cell homeostasis and self-tolerance. In this study, we aimed to evaluate the association between immune checkpoints (CTLA-4 and PD-1) and Posner-Schlossman syndrome (PSS) in a southern Chinese population. A total of 137 patients with PSS and 139 healthy controls from a southern Chinese population were recruited.

Frequency of presenting visual acuity and visual impairment in Chinese college students.

Aim: To obtain the baseline data on presenting visual acuity (PVA) and evaluate the prevalence and associated factors for visual impairment based on PVA in 9070 Chinese college students.

Methods: The freshmen at a university in southern China, including 6527 undergraduate students and 2543 graduate students, were investigated for some socio-demographic characteristics and underwent routine medical examination, including measuring PVA, height, and weight. Visual impairment was defined according to the new World Health Organization criteria for blindness and visual impairment.

Lithium chloride confers protection against viral myocarditis via suppression of coxsackievirus B3 virus replication.

Viral myocarditis (VMC) is a type of inflammation affecting myocardial cells caused by viral infection and has been an important cause of dilated cardiomyopathy (DCM) worldwide. Type B3 coxsackievirus (CVB3), a non-enveloped positive-strand RNA virus of the Enterovirus genus, is one of most common agent of viral myocarditis. Till now, effective treatments for VMC are lacking due to lack of drugs or vaccine.

[Digital simulation of unipedicular thoracolumbar vertebroplasty puncture].

Objective: To measure such operative parameters of unipedicular kyphoplasty as optimal entry point, angle and depth so as to provide rationales for its clinical management and formulate a standardized protocol for unipedicular vertebroplasty.

Methods: Ten dry thoracolumbar specimens were prepared for measurement. The entry and target points were defined according to the Roy-Camille method.