mA mRNA modification potentiates Th17 functions to inflame autoimmunity.

N-methyladenosine (mA), the most common and abundant epigenetic RNA modification, governs mRNA metabolism to determine cell differentiation, proliferation and response to stimulation. mA methyltransferase METTL3 has been reported to control T cell homeostasis and sustain the suppressive function of regulatory T cells (Tregs). However, the role of mA methyltransferase in other subtypes of T cells remains unknown.

An Efficient Routing Protocol for Quantum Key Distribution Networks.

Quantum key distribution (QKD) can provide point-to-point information-theoretic secure key services for two connected users. In fact, the development of QKD networks needs more focus from the scientific community in order to broaden the service scale of QKD technology to deliver end-to-end secure key services. Of course, some recent efforts have been made to develop secure communication protocols based on QKD.

The Signaling Pathway of PGE and Its Regulatory Role in T Cell Differentiation.

Prostaglandin E2 (PGE) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4 and CD8 T cell subsets, play crucial roles in the adaptive immune response.

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer.

Background: The four major RNA adenosine modifications, i.e., mA, mA, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the "writer" enzymes and constitute critical mechanisms of epigenetic regulation in immune response and tumorigenesis.

Mathematical model and topology evaluation of quantum key distribution network.

Due to the intrinsic point-to-point characteristic of quantum key distribution (QKD) systems, it is necessary to study and develop QKD network technology to provide a secure communication service for a large-scale of nodes over a large area. Considering the quality assurance required for such a network and the cost limitations, building an effective mathematical model of a QKD network becomes a critical task. In this paper, a flow-based mathematical model is proposed to describe a QKD network using mathematical concepts and language.

[IDUA gene mutation analysis and prenatal diagnosis of two families affected with mucopolysaccharidosis type I].

Objective: To analyze mutations of IDUA gene in two pedigrees affected with mucopolysaccharidosis type I and provide prenatal diagnosis for them.

Methods: The 14 exons of the IDUA gene were subjected to PCR amplification and Sanger sequencing.

Results: For pedigree 1, the proband was found to harbor compound heterozygous mutations c.