Comparing oxygen therapies for hypoxemia prevention during gastrointestinal endoscopy under procedural sedation: A systematic review and network meta-analysis.

Study Objective: Hypoxemia is the most frequent adverse event observed during gastrointestinal endoscopy under procedural sedation. An optimum oxygen therapy has still not been conclusively determined.

Design: A systematic review and network meta-analysis of randomized clinical trials.

Causal association between genetically predicted circulating immune cell counts and frailty: a two-sample Mendelian randomization study.

Background: Despite the recognized link between immune responses and frailty, the association between immune cell counts and frailty based on previous observational studies remains disputed, with uncertain causal nexus. This study aimed to elucidate causal association between genetically predicted circulating immune cell counts and frailty.

Methods: We conducted the two-sample Mendelian randomization (MR) study with independent genetic variants associated with six immune cell subtype counts from genome-wide association studies in 563,946 European individuals.

Forgiveness weakens women's counter-empathy both in the stage of self-oriented and other-oriented emotional responses.

Counter-empathy may have more serious negative effects on women than on men. Sixty-four female Chinese university students participated in this study. Based on the counter-empathy model in a competitive setting, we examined how forgiveness affects counter-empathy.

Quality evaluation index development for nutritional management in patients with nasopharyngeal carcinoma during peri-radiotherapy.

Objectives: It is necessary to construct an evaluation index for patients with nasopharyngeal carcinoma during peri-radiotherapy to provide a reference for the evaluation of the quality of nutritional management of patients with nasopharyngeal carcinoma during peri-radiotherapy. The aim of this study was to construct a set of scientific, comprehensive, and feasible indicators for evaluating the quality of nutrition management in patients with nasopharyngeal carcinoma during peri-radiotherapy to provide a unified reference basis for objective nutritional evaluation of these patients during the peri-radiotherapy period and to provide insights to the clinical treatment and care of these patients.

Methods: A multidisciplinary research team was set up from December 2021 to April 2022.

Greater resting frontal alpha asymmetry associated with higher emotional expressive flexibility.

Emotional expressive flexibility (EEF) is an important social ability that has prompted scholars to examine its benefits to human mental health. However, the neural underpinnings of individual differences in the EEF remain unclear. In neuroscience, frontal alpha asymmetry (FAA) is regarded as a sensitive indicator of certain emotional modalities and affective styles.

Empathy or Counter-Empathy? The Victims' Empathic Response Toward Offenders Depends on Their Relationships and Transgression Severity.

Introduction: Empathy facilitates prosocial behaviors, whereas counter-empathy harms others. The question that remains unanswered is: when and for whom do people show different empathic responses? This study aimed to explore the effects of transgression severity and interpersonal relationships on victims' empathy or counter-empathy toward an offender.

Methods: Before and after experiencing a slight or serious transgression, 42 college students were asked to imagine that they had different relationships (ie, intimate, strange, or bad) with a person and then report their empathy or counter-empathy toward that person from cognitive and affective aspects.

Functional studies of four MiFPF genes in mango revealed their function in promoting flowering in transgenic Arabidopsis.

Flowering promoting factor (FPF) genes play a substantial regulatory role in the process of flowering. In the present study, four MiFPF genes, namely, MiFPF1, MiFPF2, MiFPF3a, and MiFPF3b, were obtained from mango (Mangifera indica L.).

Molecular mechanism of benign biliary stricture inhibition by rosiglitazone-activated peroxisome proliferator-activated receptor gamma.

Objective: The aim of this study was to investigate whether rosiglitazone-activated peroxisome proliferator-activated receptor gamma can inhibit the occurrence of benign biliary stricture and further elucidate the relevant molecular signaling mechanism.

Methods: The primary cultured rat biliary fibroblasts following experiments were performed using within the fifth generation cells, which were separated from the bile ducts of Sprague-Dawley rats. The primary cultured rat biliary fibroblasts were co-cultured with 10 ng/mL transforming growth factor-beta 1 for stimulating collagen formation.

"I'm listening, did it make any difference to your negative emotions?" Evidence from hyperscanning.

Hyperscanning refers to simultaneously recording the brain activity of two or more people participating in the same cognitive activity to reveal the underlying processes. Active listening is a necessary and important part of interpersonal emotional regulation; however, few studies have addressed the corresponding brain activity. Therefore, this study aims to explore the regulatory effect of active listening and changes in the brain using functional near-infrared optical spectroscopy(fNIRS) in real situations requiring interpersonal emotional regulation.

Construction of MicroRNA-mRNA Regulatory Network in the Molecular Mechanisms of Bleomycin-Induced Pulmonary Fibrosis.

Bleomycin is a common antitumor agent used to treat many different types of malignancies; however, its main side effect is pulmonary fibrosis. The mechanism of bleomycin-induced pulmonary fibrosis (BIPF) has not been fully elucidated. Therefore, to further explore the molecular mechanisms of BIPF, we screened for microRNA (miRNA) and mRNA expression obtained from BIPF samples from the Gene Expression Omnibus database.

Low-dose paclitaxel modulates the cross talk between the JNK and Smad signaling in primary biliary fibroblasts.

Objective: The objective of this study was to explore the molecular mechanism underlying the occurrence of benign bile duct stricture and the target of low-dose paclitaxel in the prevention of benign bile duct stricture.

Methods: Under the stimulation of transforming growth factor beta 1, the expression of collagen type I and connective tissue growth factor were detected on isolated primary fibroblasts. The phosphorylation levels of JNK and Smad2L were detected using Western blot.

Collective self-referential processing evoked by different national symbols: An event-related potential study.

The collective self is an important representation of self-concept, especially for people in collectivism culture. However, it is not clear whether there are differences in the self-reference effects caused by different collective self-relevant stimuli. The present study aimed to explore the temporal characteristics of collective self-referential processing evoked by polarized and unpolarized national symbols.

The Influence of Emotional Awareness on Time Perception: Evidence From Event-Related Potentials.

Prior studies found that participants overestimated both negative and positive emotional stimuli, compared with neutral emotion. This phenomenon can be explained by the "arousal mechanism." Participants demonstrated individual differences in emotion perception.

Forgiveness weakens counterempathy at the early and late stage of empathic responses to opponents' expressions.

Our emotional response to people is discordant with their emotional experience in competitive situations; this phenomenon is termed "counterempathy." Using event-related potentials, this study investigated the neural underpinnings of the effect of forgiveness on counterempathy. Twenty-seven female university students participated in a two phase-interpersonal competitive game with two other players whose smiles and frowns indicated the participant's losing and winning, respectively.

Epithelial-mesenchymal Transition of Peritoneal Mesothelial Cells Is Enhanced by M2c Macrophage Polarization.

Background: Peritoneal fibrosis (PF) can reduce the efficiency of peritoneal dialysis and eventually lead to ultrafiltration failure. Epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is the start of PF. Macrophages are involved in the process.

"Watching Eyes" Triggers Third-Party Punishment: The Role of Emotion Within the Eyes.

Third-party punishment refers to a behavioral phenomenon whereby people punish wrongdoers even if their sanction incurs personal costs but yields no direct benefits. Given the eye cues demonstrated ability to convey signals of being observed, its effect on third-party punishment, driven by virtue of its effects on others' perceptions, was investigated. In addition, emotional message featured in the eye region is crucial in social interaction, whether the emotion within the eyes serves this effect with varying degrees of influence has rarely considered.

The influence of relationship closeness and desire for forgiveness on interpersonal forgiveness.

This study aimed to investigate the moderating effect of the desire for forgiveness on the association between relationship closeness and interpersonal forgiveness using event-related potentials (ERPs). We recruited forty student participants (20 males and 20 females) to complete the modified Taylor Aggression Paradigm (TAP), which was used to induce the offensive experience and record the victim's level of reactive aggression toward the offenders. Results indicated that for the internal intention of forgiveness behavior, when the desire for forgiveness was not expressed, participants were more forgiving of close offenders than strangers; when the desire for forgiveness was expressed, the internal intention of forgiveness behavior for strangers was similar to that for close offenders.

Prognostic Value of CT Imaging-Based Tumor Volume in Patients With Non-Surgical Esophageal Squamous Cell Carcinoma.

Background: The American Joint Committee on Cancer-Tumor (AJCC-T) staging system for esophageal carcinoma patients, which is based on the depth of tumor invasion, is not applicable in some cases. This study aims to assess the prognostic value of CT imaging-based tumor volume and its usefulness for T staging in patients with non-surgical esophageal squamous cell carcinoma (ESCC).

Methods: We retrospectively reviewed the records of 158 ESCC patients undergoing definitive (chemo) radiotherapy from two hospitals.

[Metformin inhibits collagen production in rat biliary fibroblasts: the molecular signaling mechanism].

Objective: To clarify the molecular signaling mechanism underlying the inhibitory effect of metformin on transforming growth factor-β1 (TGF-β1)-stimulated collagen I production in rat biliary fibroblasts.

Methods: Primary biliary fibroblasts were isolated under aseptic condition from 50 Sprague-Dawley rats (half male and half female), and microscopic observation identified no obvious difference in the morphology or viability of the cells from rats with different sexes or body weight. The cells were treated with TGF-β1 (10 ng/mL), Smad3 siRNA+TGF-β1, CTGF siRNA+TGF-β1, metformin (10 mmol/L)+ TGF-β1, or Compound C (10 μmol/L)+metformin+TGF-β1.

Ag-Embedded Silica Core-Shell Nanospheres for Surface Enhanced Raman Spectroscopy of High-Temperature Processes.

The construction of thermally robust, highly active, and universal substrate architectures is a major challenge for high-temperature studies using surface enhanced Raman spectroscopy (SERS). Herein, a novel hybrid nanostructure of embedded Ag nanoparticles confined by a core-shell silica nanosphere through facile chemical synthesis is reported. Benefiting from the coupling effect of embedded Ag nanojunctions and the nanoconfinement of the silica core-shell, the hybrid nanospheres exhibit strong SERS-enhancement effects and thermal stability without restrictions on the substrate generality.

Farrerol alleviates high glucose-induced renal mesangial cell injury through the ROS/Nox4/ERK1/2 pathway.

Hyperproliferation and oxidative stress induced by hyperglycemia in mesangial cells plays crucial roles in the pathological process of diabetic nephropathy. Farrerol, isolated from rhododendron leaves, possesses broad anti-oxidative and anti-inflammatory properties towards several diseases, but its role in diabetic neuropathy remains unclear. The aim of this study was to evaluate the effects of farrerol in high glucose induced mesangial cell injury, and to explore underlying molecular mechanisms.

Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats.

Macrophages in the kidney play different roles in renal interstitial fibrosis (RIF) depending on their phenotypes. M2 phenotype macrophages are believed to protect the kidney against RIF. Free fatty acid receptor GPR120 is expressed in macrophages, and its activation induces macrophage transition to M2 phenotype.

Inhibition and Production of Anger Cost More: Evidence From an ERP Study on the Production and Switch of Voluntary Facial Emotional Expression.

Humans need to flexibly produce or switch different facial emotional expressions to meet social communication need. However, little is known about the control of voluntary facial emotional expression. We investigated the production and switch of facial expressions of happiness and anger in a response-priming task of 23 Chinese female university students and recorded electroencephalographic (EEG) signals.