Highly flexible free-standing bacterial cellulose-based filter membrane with tunable wettability for high-performance water purification.

Water purification has always been a critical yet challenging issue. In this study, an organic-inorganic composite membrane was developed using 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized bacterial cellulose (BC) nanofibers and hydroxyapatite nanowires (HAPNW) with tunable wettability for advanced membrane separation applications. The resulting free-standing TEMPO-BC/HAPNW filter membrane exhibited strong mechanical strength, high flexibility, exceptional deformability, and a high pure water flux of up to 800 L·m·h due to its porous architecture and inherent hydrophilicity.

Understanding international perceptions of the severity of harmful content online.

Online social media platforms constantly struggle with harmful content such as misinformation and violence, but how to effectively moderate and prioritize such content for billions of global users with different backgrounds and values presents a challenge. Through an international survey with 1,696 internet users across 8 different countries across the world, this empirical study examines how international users perceive harmful content online and the similarities and differences in their perceptions. We found that across countries, the perceived severity consistently followed an exponential growth as the harmful content became more severe, but what harmful content were perceived as more or less severe varied significantly.

HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia.

Background: Microglial mediated neuroinflammation in the rostral ventrolateral medulla (RVLM) plays roles in the etiology of stress-induced hypertension (SIH). It was reported that autophagy influenced inflammation via immunophenotypic switching of microglia. High-mobility group box 1 (HMGB1) acts as a regulator of autophagy and initiates the production of proinflammatory cytokines (PICs), but the underlying mechanisms remain unclear.